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Stable carbenes and their use as enantioselective reagentsWilliams, Stuart John January 1998 (has links)
No description available.
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Imidazolidene and alkylidene complexes of the platinum group metalsHarlow, Karsten James January 1999 (has links)
No description available.
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Mechanistic Investigations of Gold(I) Catalyzed Hydrofunctionalizations of C-C Multiple BondsHarris, Robert Joseph January 2015 (has links)
<p>Cationic gold(I) complexes containing phosphine and N-heterocyclic carbene based ligands are a powerful catalysts for the hydrofunctionalization of C-C multiple bonds with carbon and heteroatom based nucleophiles as well as the cycloisomerization of enynes and related π-systems. Mechanisms involving outer sphere, nucleophilic attack an activated gold π-complex are typically invoked for both hydrofunctionalizations and cycloisomerizations, however, direct experimental evidence for these mechanisms remain limited.</p><p>Gold(I) catalyzed allene racemization is an important background reaction in the hydrofunctionalization of 1,3 disubstituted allenes. It can compromise chirality transfer or be exploited to realized stereoconvergent synthesis of allylic alcohols and amines. The kinetics of the racemization of aromatic 1,3-disubstituted allenes catalyzed by gold(I) phosphine complexes has been investigated. The rate of racemization displayed first order dependence on allene and gold concentration. Kinetic analysis gold(I) catalyzed racemization of allenes as a function of allene and phosphine donor ability established a depletion of electron density on the terminal allene carbons and an accumulation of electron density on the phosphine ligand in the rate-limiting transition state.</p><p>Investigation of the mechanism of gold(I) catalyzed hydrofunctionalization of allenes with alcohols, carbamates, and anilines established a variable catalyst resting state depending on the equilibrium binding affinities of the nucleophile and the relative concentrations of allene and nucleophile that are employed. Reversible C-X bond formation may explain the difference in regioselectivity observed for hydroalkoxylation and hydroamination with carbamates. Additionally, in situ analysis of the hydrofunctionalization of enatiopure 1,3-disubstituted allenes for enatiopurity of the allene and product ruled out trapping of an achiral η1-intermediate and established concomitant allene racemization as the cause of loss of enatiopurity.</p><p>Finally we report the two gold(I) carbene complexes not stabilized by π-conjugated heteroatoms. First, we report the hydride abstraction from a neutral gold cycloheptatrienyl complex that was isolated and characterized in solution and by single crystal X-ray diffraction. This complex represents the first example of a gold carbenoid complex that lacks conjugated heteroatom stabilization. Second we report the synthesis of the first gold(I) vinylidene via hydride abstraction from a gold (disilyl)ethylacetylide complex to form a cationic β,β-disilacyclopentyl vinylidene complex. The C1 and C2 carbon atoms of the vinylidene complex underwent facile interconversion presumably through the gold π-disilacyclohexyne.</p> / Dissertation
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Study of Organic Radicals through Anion Photoelectron Velocity-Map Imaging SpectroscopyDixon, Andrew, Dixon, Andrew January 2016 (has links)
Molecular and cluster anions have been investigated using photoelectron velocity-map imaging spectroscopy to study the nature of electrons in radical species. We report a negative-ion photoelectron imaging study of benzonitrile and several of its hydrated, oxygenated, and homo-molecularly solvated cluster anions. The photodetachment transition from the unsolvated benzonitrile anion to the X̃¹A₁ state of the neutral peaks at 58 ± 5 meV. The electron affinity (EA) of the lowest excited electronic state of benzonitrile, ã³A₁, is determined as 3.41 ± 0.01 eV. The next excited state, the open-shell singlet ùA₁, is found about an electron-volt above the triplet, corresponding to a vertical detachment energy of 4.45 ± 0.01 eV. The step-wise and cumulative solvation energies of benzonitrile anions by several types of species were determined, including homo-molecular solvation by benzonitrile, hydration by 1–3 waters, oxygenation by 1–3 oxygen molecules, and mixed solvation by various combinations of O₂, H₂O, and benzonitrile. Ethylene has been shown to be a degradation product following the 1-e⁻ attachment to ethylene carbonate. As a solvent molecule for (O₂)^(□), our photoelectron imaging study shows a relatively small solvation energy of ≤0.24 eV for the expected 𝜋-𝜋 interaction in the ((O₂)^(□))(C₂H₄) cluster anion. The EA of the O₂(C₂H₄) cluster was measured at 0.69 ± 0.01 eV, while the 𝑋³A″ ← 𝑋²A″ photodetachment transition shows a 1400 ± 100 cm⁻¹ vibrational progression in the 1064 nm spectrum. Negative-ion photoelectron imaging was used to investigate the substituted carbene derivative of fluoroacetonitrile. We report a closed-shell singlet ground state for the cyanofluorocarbene, FCCN, with an adiabatic electron affinity EA = 2.081 ± 0.002 eV and a singlet-triplet gap of ΔEₛ₋ₜ = 0.42 ± 0.04 eV. The open-shell singlet ¹A″ state was also observed experimentally. We find that the experimentally measured ΔEₛ₋ₜ of FCCN agrees well with the general trend of similar carbenes. We report preliminary results on the photoelectron imaging of phenylcarbene, cyanophenylcarbene, and chlorophenylcarbene anions. Triplet phenylcarbene is observed to have an EA of ≤0.83 eV, considerably lower than the previously indirectly-determined value. Transitions to the singlet and triplet ground state of both cyanophenylcarbene and chlorophenylcarbene are observable, though unidentified bands make full assignment difficult. Cyanophenylcarbene is found to have a triplet ground-state, with a tentative EA of 2.04 eV. Chlorophenylcarbene is found to have a singlet ground-state. The phenyl-group is found to favor the singlet state slightly. The cyanofluoromethyl radical, FC(H)CN, was estimated to have an EA of 1.53 ± 0.08 eV, by a combination of experimental and theoretical results.. With similar methodology, we report the adiabatic electron affinity of the cyanobenzyl radical, EA(PhCHCN) = 1.90 ± 0.01 eV, and assign an upper limit of the EA for the chlorobenzyl radical, EA(PhCHCl) ≤ 1.12 eV. These values were used to estimate the C-H bond dissociation energy (BDE)s for these substituted methanes. Fluoroacetonitrile was found to have a BDE of D𝐻₁₉₈ = 90.7 ± 2.8 kcal mol^(□1). The C-H bond dissociation energies at the benzyl-α sites of the phenylmethanes are determined as 80.9 ± 2.3 kcal mol⁻¹ for benzyl nitrile and an upper limit of 84.2 kcal mol⁻¹ for benzyl chloride. These results are discussed in terms of substituent interactions in a simple MO framework and in relation to other similar molecules, including recently reported results for chloroacetonitrile. The 532 nm photoelectron spectrum of glyoxal provides the first direct spectroscopic determination of the adiabatic electron affinity, EA = 1.10(2) eV. This assignment is supported by a Franck-Condon simulation of the experimental spectrum that successfully reproduces the observed spectral features. The vertical detachment energy (VDE) of the glyoxal radical anion is determined as VDE = 1.30(4) eV. The EA of methylglyoxal is determined as ≤0.8 eV based on the signal-to-noise ratio of the 𝑋¹A′←𝑋²A″ transition, with a VDE = 1.28(4) eV. The EA of the a³A″ ← X²A″ and 𝐴¹A″ ← 𝑋²A″ transitions are determined as 3.28(3) eV and 3.614(5) eV respectively. The intrinsically short-lived ethylenedione molecule (OCCO) was observed and investigated using anion photoelectron spectroscopy. The adiabatic electron affinity of its ³Σg^(□) ground state is 1.936(8) eV. The vibrational progression with a 417(15) cm⁻¹ frequency observed within the triplet band corresponds to a trans-bending mode. Several dissociative singlet states are also observed, corresponding to two components of the ¹Δg state and the ¹Σg⁺ state. The experimental results are in agreement with the theory predictions and constitute the first spectroscopic observation and characterization of the elusive ethylenedione molecule. Two glyoxal derivatives related to the ethylenedione anion (OCCO⁻), ethynediolide (HOCCO⁻) and glyoxalide (OHCCO⁻), were studied. These anions provide access to the corresponding neutral reactive intermediates: the HOCCO and OHCCO radicals. In the HOCCO/OHCCO anion photoelectron spectrum, we identify several electronic states of this radical system and determine the adiabatic electron affinity of HOCCO as 1.763(6) eV. This result is compared to the corresponding 1.936(8) eV value for ethylenedione (OCCO). Initial attempts were made to detect and observe the dicyanoacetylene anion, NCCCCN⁻, by photoelectron imaging. While it is believed the experimental design path of H₂⁺ abstraction from fumaronitrile is sound, no spectral signature can be assigned to NCCCCN⁻. Calculations targeting the low-lying transitions from the anion indicate that the molecule should have a significantly positive electron affinity and at least the ground state should be accessible with the currently available laser sources. The cluster ion O₂(N₂O)⁻ of the same nominal mass as NCCCCN⁻ is identified as an interfering ion and ideas have been proposed for resolving this difficulty.
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New Metal-NHC Complexes: Synthesis, Characterization, and UsesKelly, Roy A, III 16 May 2014 (has links)
N-Heterocyclic Carbenes (NHC) present a viable alternative to traditional phosphine ligands in a variety of organometallic mediated catalytic reactions. Singlet ground-state carbenes are stabilized by the push-pull presence of two adjacent nitrogen atoms in an imidizolium 5-membered ring, allowing neutral electron donor properties. The ability to synthesize a variety of NHC ligands with differing steric and electronic properties is possible by changing the sustiuents on the nitrogen atoms of the imidizolium. Tunable characteristics and enhanced chemical and thermal stability give NHC’s an advantage over phosphines in many catalytic systems.
This dissertation focuses on the use N-Hetercyclic Carbenes in a variety of organometallic complexes. The synthesis of NHC complexes with a variety of transition metals is described. The transition metals complexed with NHC’s include palladium, iridium, nickel and ruthenium. The catalytic activity of the metal-NHC complexes is investigated as well.
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CU-catalyzed enantioselective conjugate addition of organometal reagents to unsaturated carbonyls : an enantioselective total synthesis of clavirolide CBrown, Michael Kevin January 2008 (has links)
Thesis advisor: Amir H. Hoveyda / Thesis (PhD) — Boston College, 2008. / Submitted to: Boston College. Graduate School of Arts and Sciences. / Discipline: Chemistry.
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Synthesis and reactivity of scandium N-heterocyclic carbene complexesMarr, Isobel Helen January 2014 (has links)
Chapter one introduces N-heterocyclic carbenes (NHCs) and discusses their use as ligands for rare earth metal complexes, with particular emphasis upon compounds synthesised from 2009 until the present day. Chapter two details the synthesis and characterisation of the homoleptic scandium-NHC complex [Sc(L)3] (L = [OCMe2CH2(1-C{NCHCHNiPr})]). Reactions of [Sc(L)3] with boranes, CO2 and CS2 are described which exploit the relative lability of the Sc–Ccarbene bond and allow formation of [Sc(L)2(OCMe2CH2(1-B'C{NCHCHNiPr}))] (B' = 9-BBN, BPh3, B(C6F5)3, BH3), [Sc(OCMe2CH2(1-O2CC{NCHCHNiPr})3]n, [Sc(L)2(OCMe2CH2 (1-S2CC{NCHCHNiPr})] and [Sc(L)(OCMe2CH2(1-S2CC{NCHCHNiPr})2]2. The chapter also discusses the reactivity of [Sc(L)3] towards substrates containing acidic C–H and N–H bonds and substrates containing polar E–X bonds (where E = C, Si, B, P and X = Cl, I). Chapter three describes the synthesis and characterisation of the NHC substituted scandium benzyl complexes [Sc(Bn)2(L)]2 and [Sc(Bn)(L)2], and the attempted synthesis of NHC substituted scandium aminobenzyl complexes. The reactivity of [Sc(Bn)2(L)]2 with RX substrates (R = alkyl) is discussed in detail; depending on the nature of the alkyl group, these reactions can allow formation of R–Bn , the result of carbon-carbon coupling. The complex [Sc(Bn)(L)Cl]2 has been isolated from these reactions and is structurally characterised. The reactivity of [Sc(Bn)2(L)]2 towards C–H bonds is explored and attempts to prepare NHC substituted scandium hydrides are described. Comparisons of the relative stability and reactivity of [Sc(Bn)2(L)]2 and [Sc(Bn)3(thf)3] are drawn. Chapter four documents the synthesis and characterisation of [Sc(Odtbp)2(L)] (Odtbp = 2,6-di-tert-butylphenoxide), [Sc(Odtbp)(L)2], and the samarium analogue [Sm(Odtbp)(L)2]. The reactivity of these complexes towards various small molecules is described. The chapter also details attempts to prepare the cationic scandium complexes [Sc(L)2][Bort] (Bort = bis[3,3',5,5'-tetra-(tert-butyl)-2,2-diphenolato]borate) and [Sc(L)2][B(Ph)4]. Chapter five provides overall conclusions to the work presented in this thesis. Chapter six contains all experimental and characterising data for the complexes and reactions detailed in this work.
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Asymmetric Hydrogenations of Chiral Acyclic Alkenes for Important Chiron SynthesesZhu, Ye 2011 May 1900 (has links)
Hydrogenation of "largely unfunctionalized" alkenes has been an active area of research for about a decade. Many catalysts have been prepared but we noticed that comparatively few substrates have been studied and none of these hydrogenations provided useful chirons for the organic synthesis area. That motivated us to investigate
asymmetric hydrogenations of chiral acyclic alkenes, which are seldom used for hydrogenations and usually the reactions are fully substrate controlled. It emerged that
such reactions could provide a concise entry points into chirons that can be used to prepare many natural products.
Asymmetric hydrogenations of functionalized, but not coordinatively functionalized, alkenes have been used to prepare several chirons for syntheses ofpolyketide natural products using our N,carbene Crabtree's catalyst analog. Starting from optically active starting materials (eg Roche esters, lactic acid, glyceraldehyde dimethyl ketals, amino acids), highly optically active chiral alkenes can be made in several steps with high yield. With the iridium catalyzed asymmetric hydrogenations, chiral ethers, 1,3-hydroxymethyl chiron, alpha-methyl-beta-hydroxy-gamma-methyl chiron, alpha-methyl-gamma-alkyl-gamma-amino acid can be obtained with high stereoselectivities. With those well developed methodologies, (-)-dihydromyoporone, (-)-spongidepsin, (-)-invictolide have been prepared with high efficiency.
Not like the vinyl acetate, which can be hydrogenated quite well with many Rh catalysts, the alkyl vinyl ether does not have a coordination functional group nearby,
hence it is a difficult substrate for asymmetric hydrogenation and there are relatively few iv reports. Also the simple alkyl enol ether is quite acid sensitive and the Pfatlz's type N,PIr catalysts cannot hydrogenate the simple alkyl enol ethers well under the standard hydrogenation conditions. We explored many alkyl enol ethers and found some of them can be hydrogenated efficiently (50 bar H2, 1 mol percent N,carbene-Ir catalyst, 25 degree C) with high enantioselectivities (up to 98 percent ee). This study led us to suspect that more protons were produced when N,P-Ir catalyst precursors were used relative to the corresponding carbene catalyst since the former only gave complex mixture when being used. DF calculations and several other experiments supported this postulation.
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Asymmetric hydrogenations of aryl alkenes using imidazol-2-ylidene iridium complexesCui, Xiuhua 29 August 2005 (has links)
A library of iridium complexes featuring oxazoline and imidazol-2-ylidene ligands
were synthesized by reaction of a library of imidazoles with a second library of oxazoline
iodides. These complexes were active catalysts for hydrogenations of aryl substituted
monoenes. Tri- and 1,1-disubstituted alkenes were hydrogenated quantitatively with ee??s
up to 99% at 1 atm hydrogen pressure. Catalyst, substrate, temperature and pressure
effects were studied.
The iridium complexes were also used for the kinetic study of hydrogenation of 2,3-
diphenylbutadiene. This hydrogenation is a stepwise reaction: one double bond was
hydrogenated first, then the second one. Both step hydrogenations were zero order in
alkene. The consumption of 2,3-diphenylbutadiene was first order in catalyst, and
probably first order in hydrogen pressure too. The enantioselectivity for the first step
hydrogenation was low. There were match and mismatch catalyst-substrate relationships
for the second step hydrogenation, and the enantioselectivities for this step were catalyst
controlled. NMR studies indicated that the initiation of the reaction involved both
hydrogen and alkene substrate. A competitive experiment was designed to explore the
formation of meso-alkane at first step hydrogenation, and the results indicated that the
alkane was formed predominantly via an associative mechanism.
Four types of conjugate dienes were synthesized and hydrogenated. Different
reactivities and selectivities were obtained for each type of dienes. In the best case, a
diene was hydrogenated quantitatively with an excellent ent/meso ratio of 20:1.0 and
99% enantioselectivity. The scope, limitation and potential applications of the reactions
were discussed. A selection of the dienes was hydrogenated with the Crabtree??s catalyst,
for comparison, and the yields, conversions and diastereoselectivities were inferior to
those from iridium-oxazoline-imidazol-2-ylidene catalysts.
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New methods for the synthesis of complex amino acids and carbohydratesNorrish, Andrew Mark January 2001 (has links)
No description available.
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