The Cienega de Santa Clara is a 5600 ha, anthropogenic wetland in the delta of the Colorado River in Mexico. It is the inadvertent creation of the disposal of brackish agricultural waste water from the U.S. into the intertidal zone of the river delta in Mexico, but has become an internationally important wetland for resident and migratory water birds. The marsh is dominated by Typha domengensis with Phragmites australis as a sub-dominant species in shallower marsh areas. The most important factor controlling vegetation density was fire. The second significant (P<0.01) factor controlling NDVI was flow rate of agricultural drain water from the U.S. into the marsh. Reduced summer flows in 2001 due to canal repairs, and in 2010 during the YDP test run, produced the two lowest NDVI values of the time series from 2000 to 2011 (P<0.05). Salinity is a further determinant of vegetation dynamics as determined by greenhouse experiments, but was nearly constant over the period 2000 to 2011, so it was not a significant variable in regression analyses. Evapotranspiration (ET) and other water balance components were measured in Cienega de Santa Clara; we used a remote sensing algorithm to estimate ET from meteorological data and Enhanced Vegetation Index values from the Moderate Resolution Imaging Spectrometer (MODIS) sensors on the Terra satellite. We used Landsat NDVI imagery from 1978-2011 to determine the area and intensity of vegetation and to estimate evapotranspiration (ET) to construct a water balance. Remote sensing data was supplemented with hydrological data, site surveys and literature citations. The vegetated area increased from 1978 to 1995 and has been constant at about 4200 ha since then. The dominant vegetation type is Typha domingensis (southern cattail), and peak summer NDVI since 1995 has been stable at 0.379 (SD = 0.016), about half of NDVI(max). About 30% of the inflow water is consumed in ET, with the remainder exiting the Cienega as outflow water, mainly during winter months when T. domingensis is dormant.