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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
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Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
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Showing 1 to 6 of 6 (0.114 seconds)| 1 |
Advanced Algorithms for Cancer Cell Detection and TrackingJiang, Qibing 01 January 2024 (has links) (PDF)
Microscopy image processing is critical for precision oncology and immunotherapy, two approaches in cancer treatment often combined to enhance patient outcomes. Numerous scientists have studied the effects of drugs on the immune system and tumors. To quantify the impact of various drugs on different immune and cancer cell types, medical researchers conduct ex vivo assays. In these assays, patient-derived live cells are placed in an artificial microenvironment where drug responses are monitored over time. Brightfield microscopy captures one image every half hour of numerous patient-derived cells in an ex vivo reconstruction of the tumor microenvironment treated with 31 drugs for up to six days. These images are used to quantify the response of different cells to various drugs. However, tracking thousands of cells in low-resolution, low-frame-rate images remains challenging. Existing digital image processing algorithms require high-resolution images involving very few cells from homogeneous cell line populations. In this work, we propose three novel frameworks to track cancer cells, capture their behavior, and quantify cell viability to inform clinical decisions in a high-throughput manner.
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Physiological Classification of Retinal Ganglion Cells in the Salamander RetinaOhlweiler Rozenblit, Fernando 25 September 2015 (has links)
No description available.
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A Massively Parallel Algorithm for Cell Classification Using CUDASchmidt, Samuel January 2015 (has links)
No description available.
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Biofyzikální interpretace kvantitativního fázového zobrazení / Biophysical interpretation of quantitative phase imageŠtrbková, Lenka January 2018 (has links)
Práce se zabývá interpretací kvantitativního fázového zobrazení pomocí techniky koherencí řízené holografické mikroskopie. Vzhledem k tomu, že tato technika generuje velké množství kvantitativních fázových obrazů o nezanedbatelné velikosti, manuální analýza by byla časově náročná a neefektivní Za účelem urychlení analýzy obrazů získaných pomocí koherencí řízené holografické mikroskopie je v této práci navržena metodika automatizované interpretace kvantitativních fázových obrazů pomocí strojového učení s učitelem. Kvantitativní fázové obrazy umožňují extrakci parametrů charakterizujících distribuci suché hmoty v buňce a poskytují tak cennou informaci o buněčném chování. Cílem této práce je navrhnout metodologii pro automatizovanou klasifikaci buněk při využití této kvantitativní informace jak ze statických, tak z časosběrných kvantitativních fázových obrazů. Navržená metodika byla testována v experimentech s živými buňkami, jimiž byla vyhodnocena výkonnost klasifikace a významnost parametrů získaných z kvantitativních fázových obrazů.
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"Influência da composição de carreador biodegradável na viabilidade do implante de células mesenquimais indiferenciadas do tecido adiposo humano" / Influence of scaffold composition in the viability of implantation of human adipose derived undifferentiated mesenchymal cellsDietrich, Isa 09 December 2004 (has links)
Células mesenquimais indiferenciadas humanas foram obtidas por digestão enzimática e centrifugação do produto de lipoaspiração, expandidas in vitro, e implantadas no tecido subcutâneo de camundongos atímicos. No grupo I, cada animal recebeu o implante de uma membrana de 0,25cm2 de ácido glicólico e carbonato de trimetileno semeada com 1 x 106 destas células .No grupo II, cada um recebeu a injeção de 0,2ml de gel de ácido hialurônico reticulado contendo o mesmo número destas células. Com três semanas de implante, células humanas e vasos foram identificados nos dois carreadores. Entretanto, com oito semanas, somente no gel de ácido hialurônico as células humanas e os vasos estavam presentes / Human undifferentiated mesenchymal cells were obtained by enzymatic digestion and centrifugation of the product of liposuction. These cells were expanded, in vitro, and implanted subcutaneously in athymic mice. In group I, each animal received the implant of a 0,25cm2 membrane of glycolic acid and trimethylene carbonate, seeded with 1 x 106 of these cells. In group II, each one received 0,2 ml of cross-linked hyaluronic acid gel containing the same amount of these cells. With three weeks of implantation, human cells and vessels were identified in both carriers. However, with eight weeks of implantation, only in hyaluronic acid gel human cells and vessels were present
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"Influência da composição de carreador biodegradável na viabilidade do implante de células mesenquimais indiferenciadas do tecido adiposo humano" / Influence of scaffold composition in the viability of implantation of human adipose derived undifferentiated mesenchymal cellsIsa Dietrich 09 December 2004 (has links)
Células mesenquimais indiferenciadas humanas foram obtidas por digestão enzimática e centrifugação do produto de lipoaspiração, expandidas in vitro, e implantadas no tecido subcutâneo de camundongos atímicos. No grupo I, cada animal recebeu o implante de uma membrana de 0,25cm2 de ácido glicólico e carbonato de trimetileno semeada com 1 x 106 destas células .No grupo II, cada um recebeu a injeção de 0,2ml de gel de ácido hialurônico reticulado contendo o mesmo número destas células. Com três semanas de implante, células humanas e vasos foram identificados nos dois carreadores. Entretanto, com oito semanas, somente no gel de ácido hialurônico as células humanas e os vasos estavam presentes / Human undifferentiated mesenchymal cells were obtained by enzymatic digestion and centrifugation of the product of liposuction. These cells were expanded, in vitro, and implanted subcutaneously in athymic mice. In group I, each animal received the implant of a 0,25cm2 membrane of glycolic acid and trimethylene carbonate, seeded with 1 x 106 of these cells. In group II, each one received 0,2 ml of cross-linked hyaluronic acid gel containing the same amount of these cells. With three weeks of implantation, human cells and vessels were identified in both carriers. However, with eight weeks of implantation, only in hyaluronic acid gel human cells and vessels were present
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