Diss. (sammanfattning) Stockholm : Karol. inst., 2003. / Härtill 4 uppsatser.

Thesis (M.N.)--Memorial University of Newfoundland, 2003. / Typescript. Bibliography: leaves 64-71. Also available online.

Lu, Jinyan. / Thesis (Ph.D.)--Chinese University of Hong Kong, 2011. / Includes bibliographical references (leaves 75-86). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Abstract also in Chinese; some appendixes in Chinese.

Stroke remains a leading cause of disability in the western world, with symptoms ranging in severity from mild congnitive or motor impairments, to severe impairments in both cognitive and motor domains. Despite ongoing research aimed at helping stroke patients the disease cannot be prevented or cured, therefore a large body of research has been aimed at identifying effective rehabilitative strategies. Based on our understanding of normal brain function, and the meachanisms mediating the limited spontaneous recovery that is observed following injury, factors that promote brain plasticity are likely to be effective treatments for stroke symptoms. The current thesis investigated three novel treatments (COX-2 inhibitor drug, vitamin supplement diet, and social experience) in a rat model of focal ischemia in the motor cortex. All three treatments have been previously shown to alter plasticity in the normal brain, however the current experiments show that the treatments have differential effects following stroke. The COX-2 inhibitors provided limited improvement in functional performance, whereas the vitamin supplement treatment had no effect. Social experience on the other hand was found to block the usually observed spontaneous improvements following the stroke. These results suggest that factors that alter dendritic plasticity may in fact serve as effective stroke treatments depending on the site and the mechanisms whereby the plastic changes are induced. / ix, 149 leaves : ill. ; 29 cm.

Middle cerebral artery (MCA) stroke can produce chronic incapacitating motor impairments. Understanding the neural basis of the motor syndromes is complicated by the diversity of neural structures damaged but the problem can be addressed in laboratory rats by inducing selective infarcts. Nevertheless, the motor syndromes that ensue from stroke in rats remain poorly understood and undermine its potential as a model for clinical stroke. The objective of the present thesis was to document the skilled reaching impairments from neocortical and subcortical MCA infarcts in rats. In addition, the integrity of the motor system components spared by the infarct was assessed neurophysiologically and neuroanatomically. Characteristic reaching impairments emerged from each infarct but there were also some overlapping features that might be explained by neural dysfunction extending beyond the boundaries of the infarct. The present studies showed that the laboratory rat is an ideal animal model for studying stroke, which should be of interest to both clinical and research scientists studying stroke. / xiii, 345 leaves : ill. ; 29 cm. + 1 CD-ROM

The purpose of this study was to elucidate the indifferent passive behavior described in persons with right cerebral hemisphere dysfunction (Bear & Fedio, 1977; Critchley, 1966; Denny-Brown, Meyer & Horenstein, 1952). The process of caring for another person encompasses an interpersonal relationship with that person. Passive behavior may interfere with that relationship (Fried, 1970), and therefore jeopardize care. This correlational descriptive study was based on an explanatory model which included hemispheric side of lesion, attention, neglect of extrapersonal hemispace, passive behavior, and mood/emotion. The following indicators of outcome variables were used: attention--bilateral skin conductance level and skin conductance response; neglect--line bisection and cancellation tasks; passive behavior--a modification of Mays' (1973) Activity Passivity Scale; mood/emotion--the anxiety and depression subscales of Kellner and Sheffield's (1973) Symptom Rating Test. The sample comprised 10 persons with a single right hemisphere stroke and 10 persons with a left hemisphere stroke. The strength of the relationships among the variables was assessed only for persons with right hemisphere stroke. The data from this sample support some of the theorized links in the conceptual model, but not others. The predicted positive relationship between right hemisphere stroke and neglect, and the negative relationship between right hemisphere stroke and anxiety were demonstrated (r = .3177 and r = -.4353, respectively). The predicted negative relationship between right hemisphere stroke and attention was not demonstrated. Unexpected significant positive correlations existed between right hemisphere stroke and estimates of attention from the left hand (r = .3111 to r = .4472). No demonstrable relationship existed between right hemisphere stroke and passive behavior. Another unexpected finding was that the scale to scale and part to whole correlations for the concepts mood/emotion and passive behavior were strikingly different for the two groups. The fact that the two groups of subjects did not interpret the contents of the two scales similarly indicated that persons with right hemisphere dysfunction view the world quite differently from those with left hemisphere dysfunction. Appreciation of these differences may allow formulation and implementation of effective care plans which will reduce frustration in both client and caregiver.

No description available.

This thesis explores the links between emotion processing and social participation in the acute and chronic phases of stroke. Three aspects of emotion processing are examined: 1) Emotion Perception 2) Emotion Regulation 3) Depression and Anxiety. Social Participation refers to engagement in life situations including a range of social activities and social networks. Stroke survivors are known to experience a reduction in social participation, independently of activity limitations. The current research tests the hypothesis that impairments in any of the aspects of emotion processing may affect social participation. Previous research has established that following stroke, difficulties in emotion perception and depression and anxiety occur, but there is little research on post stroke emotion regulation difficulties. While the link between post stroke depression and anxiety and social participation has been explored, this is not the case with emotion perception or emotion regulation. In a pilot study, emotion processing and social participation measures were administered to stroke patients. Emotion processing difficulties were shown to occur in stroke survivors and were significantly correlated with social participation. In the main study participants’ emotion processing, social participation and activity limitations were assessed at 2 and 18 months post stroke. In the acute phase, all three aspects of emotion processing correlated with social participation, but only emotion regulation predicted social participation restrictions independently of activity limitations. In the chronic phase, emotion processing correlated with social participation, with emotion regulation and depression predicting social participation independently of activity limitations. Further analyses revealed acute phase problems with emotion perception predicted chronic phase social participation limitations, while acute phase social participation restrictions predicted chronic phase depression and emotion regulation. These findings highlight the importance of the links between emotion processing and social participation post stroke. Future research priorities in this field are outlined.

Comprueba el efecto del Programa de Habilidades Cognitivas en usuarios con Desorden Vásculo Cerebral del Hospital Nacional Daniel Alcides Carrión. El estudio de investigación fue de nivel aplicativo cuasi experimental de diseño pre y postest, de corte longitudinal. Se aplicó la evaluación del Modelo de la Discapacidad Cognitiva de Claudia Allen Allen Cognitive Level Screen (ACLS 5), para obtener el nivel cognitivo de los usuarios y el Inventario de Tareas Rutinarias (Routine Task Inventory, RTI) para determinar el desempeño en las Actividades de Vida Diaria, posteriormente se inició la intervención con actividades dirigidas al modo de desempeño obtenido por la evaluación Allen Cognitive Level Screen (ACLS 5) de cada persona y las funciones cognitivas comprometidas. Se contó con la participación de 17 usuarios, los cuales presentaban compromiso cognitivos a causa del Desorden Vasculo Cerebral o Traumatismo Encéfalo Craneano. / Tesis

No description available.