Thesis (Psy. D.)--Wheaton College Graduate School, Wheaton, IL, 2003. / Abstract. Includes bibliographical references (leaves 37-39).

New architecture will invariable be placed next to the old architecture because cities and human settlements last for generations and as humans and tribal species we invariably congregate and build new buildings to live-in, work-in and entertain in. Thus we create cities from ever increasing smaller settlements. And the city is the playground where the new merges with that which has been built already – merging the new and the old. Old town Alexandria is one such place where new and old exist side by side. There is no question that new architecture will be built. The questions are only what the new architecture will look like? What will it's existence respond to and what issues we as a society will choose to tackle with new architecture, if any. Will the new architecture and particularly infill architecture convey a purpose and meaning to rival that of its time-tested historic neighbors? And how the meaning and purpose be achieved in new architecture? This thesis explores the topic of new/ infill architecture finding place in historic districts in particular - Old Town Alexandria Historic District and Parker-Gray district. What has been the approach that has dictated the image and purpose of new architecture in historic districts in Alexandria? And can the new architecture have meaning and purpose all its own to rival that of its predecessors. / Master of Science

<p>Distinctions between set- and element-level compatibility have been made regarding stimulus-response compatibility (SRC) effects. Prior research has revealed a relationship between these two types of compatibility such that an increase in set-level effects results in an analogous increase in element-level effects. There are different ways that location information can be conveyed visually: location-words (“left” and “right”), directionalarrows (pointing left and right), and physical-locations (stimuli appearing in the left or right areas of the visual field). Set-level compatibility is higher for location-words paired with vocal “left”-“right” responses than for the other two stimulus modalities, and vice versa for pairings with left-right keypress responses, and the element-level compatibility effects differ in size accordingly.<br></p><p>My dissertation research focused on examining set- and element-level compatibility effects within the saccadic eye-movement system. These effects were considered within the dimensional overlap framework proposed by Kornblum, Hasbroucq, and Osman (1990), according to which the element-level mapping effects are an increasing function of set-level compatibility. All experiments were conducted using introductory psychology students. <br></p><p>In Experiment 1, participants responded using a left-right unimanual joystick movement or eye movement to a location-word or physical-location stimulus. In addition to an analysis of variance (ANOVA) of mean reaction time (RT) and response accuracy for the respective conditions, compatibility effects across the RT distribution were investigated by dividing trials into quantiles. Experiment 1 produced a set-level compatibility effect for the congruent mapping: Eye-movement responses (rather than joystick movements) were found to be relatively more compatible with physical-location stimuli than with location-word stimuli. In addition, the high set-level compatibility conditions exhibited a larger element-level mapping effect than the low set-level compatibility conditions. RT distribution analysis showed that both eye- and joystickmovements yielded a steadily increasing element-level mapping effect across bins, except for physical-location stimuli mapped to joystick responses, for which the function was flat. <br></p><p>In Experiment 2, the location-word stimuli used in Experiment 1 were replaced by directional-arrow stimuli. Eye movements (and not joystick movements) showed larger set- and element-level SRC effects when paired with physical-location stimuli than with directional-arrows. As in Experiment 1, the physical-location stimuli paired with eyemovement responses demonstrated an increase in the element-level mapping effect across the RT distribution. However, for the three other three set-level pairings, the elementlevel mapping effects were relatively constant across the RT distribution. This pattern further indicates a preferential benefit for eye movements paired with physical-location stimuli.<br></p><p>Experiment 3 directly compared the location-word stimuli used in Experiment 1 and the directional-arrow stimuli used in Experiment 2. The element-level mapping effect was larger for location-words than for directional-arrows, but both types of stimuli produced similar interaction patterns regarding the set-level manipulation. That is, the differences between each response modality and stimulus type produced similar patterns of element-level mapping effect differences. The location-word stimuli produced consistently large effects and served as a driving factor across the set-level comparisons. The location-words showed a large increase in element-level mapping effect across the RT distribution compared to only a small increase for the directional-arrows, which in both cases did not differ between eye- and joystick-movement responses.<br></p><p>Together the three experiments provide support for the hypothesis that eyemovement responses to physical-location stimuli are a unique, highly optimal set-level pairing relative to location-words or directional-arrows denoting spatially relevant location. In the context of a continuum outlining the relative position of different response and stimulus pairings, the results imply that eye-movement responses are similar in compatibility to joystick movements, except for the specific pairing with physical-location stimuli. <br></p><p>The results offer some support for Kornblum et al.’s (1990) account that suggests a tightly coupled relationship between set- and element-level compatibility effects. Not only do the results provide understanding about the existence of compatibility effects within the saccadic system, they allow for some considerations about how attention is allocated preferentially to certain stimuli rather than others. They also enable predictions about similar underlying mechanisms that might be involved in saccadic and manual response modalities. Taken together, it seems that the eye-movement system adheres to conventional notions about motoric behavior; however, it also has its own unique properties that make it highly tuned to exogenously guided stimuli. <br></p>

No description available.

Testosterone levels change in response to a variety of social situations including, sexual and challenge situations. Yet, little is known about the role of testosterone dynamics in in young adults in romantic relationships. Furthermore, the effect of compatibility of the relationship dyad on testosterone reactivity in response to social-challenge is unknown. Prior studies suggest that attachment levels may predict testosterone responsivity during stressors such as social challenge. What is missing from the literature is whether testosterone response to social-challenge is specifically modified within the confines of an attachment relationship, such as within romantic couples. I measured salivary testosterone in healthy romantically involved young adult couples in response to a examined romantic couples during a standardized laboratory stressor in the SPIT lab. Testosterone was measured repeatedly from saliva in both members of each dyad and assayed using an enzymeimmunoassay. Participants completed questionnaires measuring perceived relationship commitment, support, satisfaction, and passion. This was collectively described as relationship compatibility. I revealed that participants in romantic relationships showed significant testosterone response to the Trier Social Stress Test (TSST). Testosterone levels of the participant were moderated by testosterone levels of the supporter during the socialchallenge, such that the supporter’s response was coupled with their partner’s testosterone response to stress. When the couples reported high-compatibility, their testosterone profiles were more coupled than for couples reporting low-compatibility. Findings fit within the challenge hypothesis and extend it in interesting ways. Testosterone may help an individual confront a challenge, and, more interestingly, testosterone may help a couple confront a challenge together.

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Invasive aspergillosis (IA) is associated with high mortality rates and can be difficult and expensive to treat with current drugs. The drugs used to treat IA are also associated with undesirable, and often severe, side-effects of the patient. The main causative agent of this disease is the opportunistic pathogen Aspergillus fumigatus. This study identifies genes which play a role in a fungal-specific type of programmed cell death (PCD) in A. fumigatus, known as heterokaryon incompatibility. The development of drugs specifically targeting the products of these genes could lead to fewer side-effects than those arising from currently available anti-fungal drugs. The drug amphotericin B is currently used to treat IA and has been shown to induce an apoptotic-like phenotype in A. fumigatus; however, the sterols targeted are present in both fungal and mammalian cell membranes. HI is a fungal-specific self/non-self recognition system that results in rapid compartmentalisation and cell death of hyphal fusion sites if the two fusing fungi are not genetically compatible. The HI system could be exploited as a novel drug target against invasive fungal pathogens through targeting a component of the molecular pathway to induce cell death. In contrast to current drugs, novel drugs could target HI components to induce PCD without affecting non-desirable targets that cause side-effects. The non-self recognition systems used by Neurospora crassa, Aspergillus Nidulans and Podospora anserina are the well characterised, and they each differ significantly in their modes of action. BLAST searches found 30 homologues of HI genes from other the systems of characterised species in A. fumigatus, with 8 containing the fungal-specific het domain. The first assay to determine whether disruption of het genes could affect HI was to observe the barrage phenotype between incompatible A. fumigatus individuals. However, there was no barrage visible as the leading edge of colonies stopped growing when in close proximity to another colony. Instead, nitrate non-utilising (Nit) A. fumigatus mutant strains were generated using chlorate and pair-wise crosses of 46 environmentally and clinically isolates on nitrate-containing media resulted in the formation of 16 viable heterokaryons. All of the heterokaryons fell into exclusive compatibility groups where no intergroup crossing was possible. Homologous recombination was used to disrupt five of the identified het domain genes with gene replacement cassettes, generated through fusion-PCR, in an akuB(KU80Delta) A. fumigatus strain. The mutant strains displayed both detrimental growth on standard agar growth media and reduced ability to recognise non-self strains. Full and partial heterokaryons were formed during intergroup pair-wise compatibility crosses using the mutants and strains that the akuB(KU80Delta) parent strain was previously incompatible with. This was followed with a non-bias approach of gene disruption using the Fusarium oxysporum impala160 transposable element in a Nit A. fumigatus mutant. Inducing transposon mutagenesis through exposure to low temperature generated a mutant library of spores in which the transposon had disrupted different open reading frames at different locations across the A. fumigatus genome. The mutant spore library was also screened for the ability to form viable intergroup heterokaryons with strains belonging to different compatibility groups. PCR recovery and DNA sequencing was able to identify the locus of impala160 in three isolates able to form viable heterokaryons. The sequences revealed the transposable element had disrupted the same gene, AFUA_2G05070, in each of the three isolates. This gene encodes an uncharacterised conserved hypothetical protein which may be a critical component for non-self recognition in A. fumigatus HI, and a potential target for novel anti-fungal drugs to induce PCD.

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This research contributes to the existing body of knowledge relating to crash compatibility (the minimisation of injury risk faced by all participants involved in a collision in traffic). The research focuses on the topic of structural interaction in collisions involving passenger vehicles, a phenomenon describing the efficiency of energy dissipation within existing deformation-zones of a passenger vehicle during a collision. A new definition for structural interaction was developed and several metrics to evaluate structural interaction and compatibility in car-to-car collisions were proposed, based on the commonly known Equivalent Energy Speed (EES) metric. The new EES metrics describe equivalent closing velocities for a given collision based on the energy dissipated within the front-ends (EESFF) and the entire structure (EESVV) of both vehicles involved in a head-on collision. These metrics form the basis of the new knowledge generated by this research. Additionally, a new method was developed to measure the amount of energy dissipated through structural deformation in a collision, based on accelerometer readings. This method was applied to several experimental and simulationbased car-to-car collisions and the validity of the method was proven. Based on the energy dissipation which occurred in the car-to-car collisions analysed, the degree of compatibility reached and the level of structural interaction which occurred in each collision was evaluated by applying the newly developed EESFF and EESVV metrics. Thie research also investigates the assessment of vehicles' structures in a standardized procedure with a view to improving structural interaction in the real-world. Several fixed barrier crash tests have been proposed in different configurations and with different assessment criteria. All assessments aim to evaluate the geometrical characteristics of the front-ends of passenger vehicles. A set of factors required from a compatilibility assessment focused on assessing vehicle geometry were identified. The proposed compatibility assessment procedures were evaluated based on their ability to predict the potential for structural interaction offered by passenger vehicles.

The middle period of the 20th century, the births of electronic calculator and information transmission technology, let the civilized development course be faster. Under the situation in the considerable and significant growth of product-producing and cultural dissemination , the compatibility of products is shaped into the top theme that sought together by customers and manufacturers .The growth of the diverse products in markets gives a chance of option to the users in markets .This research shows that it will only be after undergoing the marketable course of competition certainly when every manufacturer introduces the products , could determines that whether it's a market that monopolize or a situation that is formed by the incompatibility of every product from each manufacturer. Based this background, The research was done by using language Visual Basic to write a function about marketing share¡Buser preference ¡Btechnology and strategy to confer when ¡Bwhy and how the competing technologies will become Monopoly or have marketing shares with each other in a long period. From the conclusion of this research, we know what will the firms do under the supposition of this research and there is the description about the limit in this research and the feasibility study in the future.