京都大学 / 0048 / 新制・論文博士 / 博士(医学) / 乙第13161号 / 論医博第2148号 / 新制||医||1029(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授 大森 孝一, 教授 松本 智裕, 教授 秋山 芳展 / 学位規則第4条第2項該当 / Doctor of Medical Science / Kyoto University / DFAM

京都大学 / 0048 / 新制・課程博士 / 博士(農学) / 甲第21379号 / 農博第2303号 / 新制||農||1071(附属図書館) / 学位論文||H30||N5152(農学部図書室) / 京都大学大学院農学研究科応用生命科学専攻 / (主査)教授 栗原 達夫, 教授 植田 充美, 教授 小川 順 / 学位規則第4条第1項該当 / Doctor of Agricultural Science / Kyoto University / DGAM

京都大学 / 0048 / 新制・課程博士 / 博士(人間健康科学) / 甲第21459号 / 人健博第66号 / 新制||人健||5(附属図書館) / 京都大学大学院医学研究科人間健康科学系専攻 / (主査)教授 青山 朋樹, 教授 岡 昌吾, 教授 髙橋 良輔 / 学位規則第4条第1項該当 / Doctor of Human Health Sciences / Kyoto University / DFAM

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Bakgrund: Användningen av nanopartiklar ökar varje dag men mycket är oklart i vilkenutsträckning nanopartiklar har hälsopåverkan hos människor. I studier har det visats attnanopartiklar under 100 nm kan passera cellmembranet och under 40 nm kan passeranuklearmembran. I dagsläget används guldnanopartiklar (GNP) inom medicin för visualisering, diagnostisering och läkemedelsbärare. En av biverkningar som GNP kan ha är inflammation. Det finns flera studier som försökt redogöra GNP:s effekter samt hur de uppkommer men det är intehelt klarlagt. Vidare är det inte helt tydligt vilka egenskaper hos GNP som står för de olikaeffekterna. Syfte: Syftet med studien är att undersöka rollen som GNP:s storlekar och former har i NLRfamily pyrin domain containing 3 (NLRP3) inflammasomens interleukin-1β-frisättning hoshuman leukemia monocytic cell line (THP1-celler). Metod: Studien är en experimentell studie där THP1-celler differentieras och exponeras för GNPi olika storlekar, former och koncentrationer. LUMIT immunoassay används sedan för att erhållade olika interleukin-1β-koncentrationerna (IL-1β). Resultat: I datan som erhölls efter att experimenten utförts observerades det att GNP 30 nm i 40μg/mL gav störst inflammasominduktion med en IL-1β-koncentration på 645 ±388 pg/mL.Nästhögst IL-1β-koncentration gav GNP 100 nm i 40 μg/mL på 592 ±270 pg/mL. Slutsats: Nakna GNP kan inducera inflammasomaktivering och på så sättIL-1β-koncentrationshöjningar. De “gold urchins” som undersökts visade sig ha svagarepåverkan på cellerna jämfört med de sfäriska GNP.

Sugar is intrinsically linked with the modern food system. Large sections of the U. K. food industry are dependent on its use and functional qualities. Supplies of sucrose entering the food chain have declined 25% between the 1950's and 1980's and currently stand around 37 kg/person/year. Furthermore, U. K. dietary guidelines over the past 14 years have consistently suggested caution over how much sugar is eaten, especially in manufactured foods. Dietary guidelines such as the NACNE report (1983) recommend average sugar consumption should be no more than 20 kg/person/year. Currently, two-thirds of sugar supplies are bought for use in food and drink manufacture. Continued pressures on sugar consumption and negative consumer attitudes to sugar may be reflected in lost sales of sugar-containing foods. The available information on U. K. sugar consumption is critically assessed. Although the main sources of sugar supply are identified, individual sugar consumption is shown to vary by considerable amounts. The place of sucrose is examined in relation to other sweeteners and why and where sugars and sweeteners are used in food systems. The promotion of "no added sugar" and "sugar free" products is examined since the publication of the NACNE report to the end of 1987. To further test the impact of changing patterns of sugar consumption on food and drink manufacturers a national survey of manufacturers who use sugar was carried out in early 1988. This was an attitudinal postal questionnaire and responses to the issue of sugar, diet and health were analysed. Respondents bought an estimated 650,000 tonnes of sugar in 1986, around 45% of the total industrial market. While the survey aggregate were fully supportive of sucrose, respondents reported that the majority of consumers were worried about sugar being bad for health and were actively cutting down on individual intakes. There were significant differences to the issue of sugar, diet and health dependent on company size, whether a company manufactured for a retailer's own label and if products had already been marketed at a "healthy eating" segment. However, in general, while manufacturers considered consumer attitudes to sugar to be important they had to be put in the context of other factors. So far the impact of changing patterns of sugar consumption is not reflected in the total average industrial purchases of sugar, although substantial "sugar-free" and "sugar-reduced" product niches have been established.

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