This study investigates how hate crimes in general and anti-Arab hate crimes in particular were distributed across different regions of the United States during the 2001-2002 period. The study explores how a historical event the terrorist attacks against the U.S. on September 11, 2001 and county population demographics affect the rates of hate crime against Arabs, Muslims or Middle Easterners. It was hypothesized that anti-Arab or anti-Muslim hate crimes displaced other forms of hate crime and were characterized by open acts of violence. According to the contact hypothesis, anti-Arab and anti-Muslim hate crimes would be more likely to occur in counties with relatively high levels of poverty and economic inequality. The research materials were obtained from publicly available data. The hate crime data were obtained from the national hate crime incidents reported to the FBI Uniform Crime Reports (UCR) program.

Two randomized controlled trials were conducted to find out whether a new treatment for asthma has a significant effect on the patients. These were multi-center trials with a parallel design, the control arm receiving a Placebo. The data were collected over a period of about 20 days before administering the intervention and for almost 80 days after the intervention. Thus, each patient has many observations recorded, making the data longitudinal. The data are summarized using first descriptive statistics and graphical displays. Then, a continuation ratio model with a lagged covariate to account for the longitudinal aspect is used to model the data. Finally, Generalized Estimating Equations methods are used. These methods have acquired popularity in recent years to account for longitudinal correlation structures. To apply the continuation ratio, the data have to be appropriately restructured. Then, the logistic regression is used to model the symptoms. The results of this procedure show that the treatment is statistically significant. However, the goodness of fit tests show that the model is inadequate. This issue is explored in the last subsection of Chapter 3. Using Generalized Estimating Equations to analyze the number of times rescue medication was used, we concluded that there is no statistically significant difference between the Active and Control groups. However, we noticed that the use of rescue medication decreased with time from the start of treatment. / Thesis / Master of Science (MS)

The dynamics around managing urban infrastructure are changing dramatically. Today???s infrastructure management challenges ??? in the wake of shrinking coffers and stricter stakeholders??? requirements ??? include finding better condition assessment tools and prediction models, and effective and intelligent use of hard-earn data to ensure the sustainability of urban infrastructure systems. Wastewater collection networks ??? an important and critical component of urban infrastructure ??? have been neglected, and as a result, municipalities in North America and other parts of the world have accrued significant liabilities and infrastructure deficits. To reduce cost of ownership, to cope with heighten accountability, and to provide reliable and sustainable service, these systems need to be managed in an effective and intelligent manner. The overall objective of this research is to present a new strategic management framework and related tools to support multi-perspective maintenance, rehabilitation and replacement (M, R&R) planning for wastewater collection networks. The principal objectives of this research include: (1) Developing a comprehensive wastewater collection network asset database consisting of high quality condition assessment data to support the work presented in this thesis, as well as, the future research in this area. (2) Proposing a framework and related system to aggregate heterogeneous data from municipal wastewater collection networks to develop better understanding of their historical and future performance. (3) Developing statistical models to understand the deterioration of wastewater pipelines. (4) To investigate how strategic management principles and theories can be applied to effectively manage wastewater collection networks, and propose a new management framework and related system. (5) Demonstrating the application of strategic management framework and economic principles along with the proposed deterioration model to develop long-term financial sustainability plans for wastewater collection networks. A relational database application, WatBAMS (Waterloo Buried Asset Management System), consisting of high quality data from the City of Niagara Falls wastewater collection system is developed. The wastewater pipelines??? inspections were completed using a relatively new Side Scanner and Evaluation Technology camera that has advantages over the traditional Closed Circuit Television cameras. Appropriate quality assurance and quality control procedures were developed and adopted to capture, store and analyze the condition assessment data. To aggregate heterogeneous data from municipal wastewater collection systems, a data integration framework based on data warehousing approach is proposed. A prototype application, BAMS (Buried Asset Management System), based on XML technologies and specifications shows implementation of the proposed framework. Using wastewater pipelines condition assessment data from the City of Niagara Falls wastewater collection network, the limitations of ordinary and binary logistic regression methodologies for deterioration modeling of wastewater pipelines are demonstrated. Two new empirical models based on ordinal regression modeling technique are proposed. A new multi-perspective ??? that is, operational/technical, social/political, regulatory, and finance ??? strategic management framework based on modified balanced-scorecard model is developed. The proposed framework is based on the findings of the first Canadian National Asset Management workshop held in Hamilton, Ontario in 2007. The application of balanced-scorecard model along with additional management tools, such as strategy maps, dashboard reports and business intelligence applications, is presented using data from the City of Niagara Falls. Using economic principles and example management scenarios, application of Monte Carlo simulation technique along with the proposed deterioration model is presented to forecast financial requirements for long-term M, R&R plans for wastewater collection networks. A myriad of asset management systems and frameworks were found for transportation infrastructure. However, to date few efforts have been concentrated on understanding the performance behaviour of wastewater collection systems, and developing effective and intelligent M, R&R strategies. Incomplete inventories, and scarcity and poor quality of existing datasets on wastewater collection systems were found to be critical and limiting issues in conducting research in this field. It was found that the existing deterioration models either violated model assumptions or assumptions could not be verified due to limited and questionable quality data. The degradation of Reinforced Concrete pipes was found to be affected by age, whereas, for Vitrified Clay pipes, the degradation was not age dependent. The results of financial simulation model show that the City of Niagara Falls can save millions of dollars, in the long-term, by following a pro-active M, R&R strategy. The work presented in this thesis provides an insight into how an effective and intelligent management system can be developed for wastewater collection networks. The proposed framework and related system will lead to the sustainability of wastewater collection networks and assist municipal public works departments to proactively manage their wastewater collection networks.

Alzheimer's Disease (AD) affects nearly 5.4 million Americans as of 2016 and is the most common form of dementia. The disease is characterized by the presence of neurofibrillary tangles and amyloid plaques [1]. The amount of plaques are measured by Braak stage, post-mortem. It is known that AD is positively associated with hypercholesterolemia [16]. As statins are the most widely used cholesterol-lowering drug, there may be associations between statin use and AD. We hypothesize that those who use statins, specifically lipophilic statins, are more likely to have a low Braak stage in post-mortem analysis. In order to address this hypothesis, we wished to fit a regression model for ordinal outcomes (e.g., high, moderate, or low Braak stage) using data collected from the National Alzheimer's Coordinating Center (NACC) autopsy cohort. As the outcomes were matched on the length of follow-up, a conditional likelihood-based method is often used to estimate the regression coefficients. However, it can be challenging to solve the conditional-likelihood based estimating equation numerically, especially when there are many matching strata. Given that the likelihood of a conditional logistic regression model is equivalent to the partial likelihood from a stratified Cox proportional hazard model, the existing R function for a Cox model, coxph( ), can be used for estimation of a conditional logistic regression model. We would like to investigate whether this strategy could be extended to a regression model for ordinal outcomes. More specifically, our aims are to (1) demonstrate the equivalence between the exact partial likelihood of a stratified discrete time Cox proportional hazards model and the likelihood of a conditional logistic regression model, (2) prove equivalence, or lack there-of, between the exact partial likelihood of a stratified discrete time Cox proportional hazards model and the conditional likelihood of models appropriate for multiple ordinal outcomes: an adjacent categories model, a continuation-ratio model, and a cumulative logit model, and (3) clarify how to set up stratified discrete time Cox proportional hazards model for multiple ordinal outcomes with matching using the existing coxph( ) R function and interpret the regression coefficient estimates that result. We verified this theoretical proof through simulation studies. We simulated data from the three models of interest: an adjacent categories model, a continuation-ratio model, and a cumulative logit model. We fit a Cox model using the existing coxph( ) R function to the simulated data produced by each model. We then compared the coefficient estimates obtained. Lastly, we fit a Cox model to the NACC dataset. We used Braak stage as the outcome variables, having three ordinal categories. We included predictors for age at death, sex, genotype, education, comorbidities, number of days having taken lipophilic statins, number of days having taken hydrophilic statins, and time to death. We matched cases to controls on the length of follow up. We have discussed all findings and their implications in detail.

The dynamics around managing urban infrastructure are changing dramatically. Today’s infrastructure management challenges – in the wake of shrinking coffers and stricter stakeholders’ requirements – include finding better condition assessment tools and prediction models, and effective and intelligent use of hard-earn data to ensure the sustainability of urban infrastructure systems. Wastewater collection networks – an important and critical component of urban infrastructure – have been neglected, and as a result, municipalities in North America and other parts of the world have accrued significant liabilities and infrastructure deficits. To reduce cost of ownership, to cope with heighten accountability, and to provide reliable and sustainable service, these systems need to be managed in an effective and intelligent manner. The overall objective of this research is to present a new strategic management framework and related tools to support multi-perspective maintenance, rehabilitation and replacement (M, R&R) planning for wastewater collection networks. The principal objectives of this research include: (1) Developing a comprehensive wastewater collection network asset database consisting of high quality condition assessment data to support the work presented in this thesis, as well as, the future research in this area. (2) Proposing a framework and related system to aggregate heterogeneous data from municipal wastewater collection networks to develop better understanding of their historical and future performance. (3) Developing statistical models to understand the deterioration of wastewater pipelines. (4) To investigate how strategic management principles and theories can be applied to effectively manage wastewater collection networks, and propose a new management framework and related system. (5) Demonstrating the application of strategic management framework and economic principles along with the proposed deterioration model to develop long-term financial sustainability plans for wastewater collection networks. A relational database application, WatBAMS (Waterloo Buried Asset Management System), consisting of high quality data from the City of Niagara Falls wastewater collection system is developed. The wastewater pipelines’ inspections were completed using a relatively new Side Scanner and Evaluation Technology camera that has advantages over the traditional Closed Circuit Television cameras. Appropriate quality assurance and quality control procedures were developed and adopted to capture, store and analyze the condition assessment data. To aggregate heterogeneous data from municipal wastewater collection systems, a data integration framework based on data warehousing approach is proposed. A prototype application, BAMS (Buried Asset Management System), based on XML technologies and specifications shows implementation of the proposed framework. Using wastewater pipelines condition assessment data from the City of Niagara Falls wastewater collection network, the limitations of ordinary and binary logistic regression methodologies for deterioration modeling of wastewater pipelines are demonstrated. Two new empirical models based on ordinal regression modeling technique are proposed. A new multi-perspective – that is, operational/technical, social/political, regulatory, and finance – strategic management framework based on modified balanced-scorecard model is developed. The proposed framework is based on the findings of the first Canadian National Asset Management workshop held in Hamilton, Ontario in 2007. The application of balanced-scorecard model along with additional management tools, such as strategy maps, dashboard reports and business intelligence applications, is presented using data from the City of Niagara Falls. Using economic principles and example management scenarios, application of Monte Carlo simulation technique along with the proposed deterioration model is presented to forecast financial requirements for long-term M, R&R plans for wastewater collection networks. A myriad of asset management systems and frameworks were found for transportation infrastructure. However, to date few efforts have been concentrated on understanding the performance behaviour of wastewater collection systems, and developing effective and intelligent M, R&R strategies. Incomplete inventories, and scarcity and poor quality of existing datasets on wastewater collection systems were found to be critical and limiting issues in conducting research in this field. It was found that the existing deterioration models either violated model assumptions or assumptions could not be verified due to limited and questionable quality data. The degradation of Reinforced Concrete pipes was found to be affected by age, whereas, for Vitrified Clay pipes, the degradation was not age dependent. The results of financial simulation model show that the City of Niagara Falls can save millions of dollars, in the long-term, by following a pro-active M, R&R strategy. The work presented in this thesis provides an insight into how an effective and intelligent management system can be developed for wastewater collection networks. The proposed framework and related system will lead to the sustainability of wastewater collection networks and assist municipal public works departments to proactively manage their wastewater collection networks.