This project was carried out in order to complete the requirements of the Master of Engineering Management degree at the University of Canterbury. The project objective was to examine the reasons for Attainment to Plan (ATP) misses at the Meadow Fresh Christchurch plant, specifically the Fresh Beverages division. ATP is a measure of how closely the production team follows the daily packing plan, and is a site Key Performance Indicator (KPI). This report describes the action plans that were developed to decrease the number of misses to the target value, an analysis of the success of these plans, and recommendations which were made around the purchase of plant equipment in order to further improve the ATP results.

Continuous Quality Improvement (CQI) is a set of constructs, principles, and tools aimed at continually improving organizational processes. While thousands of organizations worldwide have adopted CQI, there are still many gaps in our knowledge of how to get the most out of CQI efforts. This paper addresses several of these gaps, including the limitations of existing CQI theory and the inconsistencies regarding the implementation of CQI at team and departmental levels. After discussing the basic principles of CQI, a framework for understanding and utilizing CQI is offered. Then, the results of 102 interviews, conducted with team leaders and department heads in a large hospital in the Southwestern United States, are presented. These results suggest that CQI team effectiveness is most influenced by goal specificity, team composition, and team leader training in statistical process control (SPC). Other factors, including team leader attitude toward CQI and team CQI skills, were also related to CQI team effectiveness. Departmental results were less clear. Only department head attitude toward CQI was significantly correlated with departmental CQI implementation. Potential meanings and implications of these findings are discussed, suggestions for implementing CQI in teams and departments are offered, and directions for future research are provided.

Individuals and organizations must continuously improve to succeed in today’s competitive economic climate, yet a major dilemma in tough economic conditions is that the resources needed to support such proactive improvement behaviors are limited. Existing theories on organizational resources, stressors, and continuous improvement are relevant yet insufficient for answering the important question of how individuals remain motivated to pursue continuous improvement activities despite minimal organizational resources to support them. Therefore, the goal of this dissertation was to build and test theory on this phenomenon. Inspired by full-cycle research, I began this program of research with a phenomenological study of employees in a manufacturing environment to better understand their appraisals regarding continuous improvement under resource-constrained conditions. The results highlighted the ways in which employees interpret constraints as either a threat or a challenge, and how positive psychological capital (PsyCap) guides these interpretations and subsequent continuous improvement. Informed by this rich data, I proposed a synthesized theoretical model which was tested in two separate contexts. First, I conducted a time-lagged survey study in another resource-constrained environment that demands continuous improvement, namely entrepreneurs launching a new business. To exert more control and to enhance the generalizability of this research, I then conducted an online experiment with participants from various industries and backgrounds. The results of these studies largely supported the theoretical model, documenting in particular the importance of individuals’ challenge appraisals for their ensuing continuous improvement behaviors. The benefits of individuals’ positive psychological resources as a way to enhance the perceived learning opportunities from resource constraints (i.e., challenge appraisal) were also illustrated. Threat appraisals did not produce the expected effects in this context of continuous improvement, and as such, the theoretical model was refined further. Collectively, this research provides answers to the important question of how individuals can find ways to proactively improve in the face of resource constraints, which is a timely and relevant topic across contemporary organizational contexts today. / Thesis (Ph.D, Management) -- Queen's University, 2013-09-27 18:02:23.883

Continuous-time Markov chains (CTMC's) form a convenient mathematical framework for analyzing random systems across many different disciplines. A specific research problem that is often of interest is to try to predict maximum probability sequences of state transitions given initial or boundary conditions. This work shows how to solve this problem exactly through an efficient dynamic programming algorithm. We demonstrate our approach through two different applications - ranking mutational pathways of HIV virus based on their probabilities, and determining the most probable failure sequences in complex fault-tolerant engineering systems. Even though CTMC's have been used extensively to realistically model many types of complex processes, it is often a standard practice to eventually simplify the model in order to perform the state evolution analysis. As we show here, simplifying approaches can lead to inaccurate and often misleading solutions. Therefore we expect our algorithm to find a wide range of applications across different domains.

Hydrogenation of nitrile butadiene rubber (NBR) has been carried out industrially for a number of years, producing a material with exceptional resilience to high temperatures and oxidative conditions. Current processes involve a batch reactor which is difficult to optimize further for larger scale production. A continuous process for this particular process is required in order to provide a large volume of production with consistent qualities. The integration of heat balance could be realized in a continuous process. A novel continuous process for hydrogenation of NBR has been developed in the present work. A multistage agitated contactor (MAC) was proposed as a gas liquid reactor for this process. Comprehensive hydrodynamic data have been acquired under various process conditions. The hydrodynamic behaviour under different operating variables such as stirring speed, liquid flow rate and gas flow rate has been understood through experimental study. It is found that an increase in stirring speed intensifies liquid backmixing while an increase liquid flow rate decreases liquid backmixing. The presence of gas flow helps in reducing liquid back mixing by two coupled effects: liquid entrainment effect due to a cocurrent operation manner and a strengthening effect of liquid flow rate due to its reduction of liquid hold-up. Contradictory conclusions regarding the effect of liquid viscosity on liquid backmixing in a MAC have been resolved through experimental investigation and computational fluid dynamics (CFD) simulations. It is shown that an increase in liquid velocity dampens turbulence which contributes to liquid phase backmixing within the reactor. The established hydrodynamic understanding of MACs in the present work widens its potential application for gas liquid process. Based on comprehensive understanding of the proposed reactor, a bench-scale prototype was designed and constructed in order to demonstrate hydrogenation performance. One more efficient catalyst for NBR hydrogenation, an osmium-based catalyst, was used in the present work. Hydrogenation degree of NBR in the continuous unit was investigated at operating conditions relevant to industrial applications. It is indicated from the experimental results that a desired hydrogenation degree of over 95% in 2.5% and 5% NBR solutions can be achieved at the conditions investigated. It is also shown that both system pressure and catalyst loading increase hydrogenation conversion. Mathematical modeling of the designed process was established by coupling the intrinsic catalytic hydrogenation from batch studies and flow behavior of the reactor. A cascade of stirred tanks with back flow (CTB) model was used to characterize the dynamic hydrogenation performance in a MAC. The comparison of experimental results and numerical prediction indicates that the established model could satisfactorily predict the hydrogenation in the designed process with consideration of approximately 30%-50% catalyst deactivated due to impurities and oxygen contamination in the polymer solution. A revised n CSTRs-in-series model was proposed to predict the hydrogenation degree at steady state and a good agreement was found when comparing the predicted results with the experimental data. A continuous process for hydrogenation at a pilot scale was designed based on the primary results from the bench scale process. A process with a capacity of 50 tons/year was targeted and the hydrogenation efficiency provided by the pilot scale unit has been estimated through the established reactor model.

Based on ethanol fermentation kinetics and bioreactor engineering theory, a system composed of a continuously stirred tank reactor (CSTR) and three tubular bioreactors in series was established for continuous very high gravity (VHG) ethanol fermentation with Saccharomyces cerevisiae. Sustainable oscillations of residual glucose, ethanol, and biomass characterized by long oscillation periods and large oscillation amplitudes were observed when a VHG medium containing 280 g/L glucose was fed into the CSTR at a dilution rate of 0.027 h???1. Mechanistic analysis indicated that the oscillations are due to ethanol inhibition and the lag response of yeast cells to ethanol inhibition. A high gravity (HG) medium containing 200 g/L glucose and a low gravity (LG) medium containing 120 g/L glucose were fed into the CSTR at the same dilution rate as that for the VHG medium, so that the impact of residual glucose and ethanol concentrations on the oscillations could be studied. The oscillations were not significantly affected when the HG medium was used, and residual glucose decreased significantly, but ethanol maintained at the same level, indicating that residual glucose was not the main factor triggering the oscillations. However, the oscillations disappeared after the LG medium was fed and ethanol concentration decreased to 58.2 g/L. Furthermore, when the LG medium was supplemented with 30 g/L ethanol to achieve the same level of ethanol in the fermentation system as that achieved under the HG condition, the steady state observed for the original LG medium was interrupted, and the oscillations observed under the HG condition occurred. The steady state was gradually restored after the original LG medium replaced the modified one. These experimental results confirmed that ethanol, whether produced by yeast cells during fermentation or externally added into a fermentation system, can trigger oscillations once its concentration approaches to a criterion. The impact of dilution rate on oscillations was also studied. It was found that oscillations occurred at certain dilution rate ranges for the two yeast strains. Since ethanol production is tightly coupled with yeast cell growth, it was speculated that the impact of the dilution rate on the oscillations is due to the synchronization of the mother and daughter cell growth rhythms. The difference in the oscillation profiles exhibited by the two yeast strains is due to their difference in ethanol tolerance. For more practical conditions, the behavior of continuous ethanol fermentation was studied using a self-flocculating industrial yeast strain and corn flour hydrolysate medium in a simulated tanks-in-series fermentation system. Amplified oscillations observed at the dilution rate of 0.12 h???1 were postulated to be due to the synchronization of the two yeast cell populations generated by the continuous inoculation from the seed tank upstream of the fermentation system, which was partly validated by oscillation attenuation after the seed tank was removed from the fermentation system. The two populations consisted of the newly inoculated yeast cells and the yeast cells already adapted to the fermentation environment. Oscillations increased residual sugar at the end of the fermentation, and correspondingly, decreased the ethanol yield, indicating the need for attenuation strategies. When the tubular bioreactors were packed with ????? Intalox ceramic saddles, not only was their ethanol fermentation performance improved, but effective oscillation attenuation was also achieved. The oscillation attenuation was postulated to be due to the alleviation of backmixing in the packed tubular bioreactors as well as the yeast cell immobilization role of the packing. The residence time distribution analysis indicated that the mixing performance of the packed tubular bioreactors was close to a CSTR model for both residual glucose and ethanol, and the assumed backmixing alleviation could not be achieved. The impact of yeast cell immobilization was further studied using several different packing materials. Improvement in ethanol fermentation performance as well as oscillation attenuation was achieved for the wood chips, as well as the Intalox ceramic saddles, but not for the porous polyurethane particles, nor the steel Raschig rings. Analysis for the immobilized yeast cells indicated that high viability was the mechanistic reason for the improvement of the ethanol fermentation performance as well as the attenuation of the oscillations. A dynamic model was developed by incorporating the lag response of yeast cells to ethanol inhibition into the pseudo-steady state kinetic model, and dynamic simulation was performed, with good results. This not only provides a basis for developing process intervention strategies to minimize oscillations, but also theoretically support the mechanistic hypothesis for the oscillations.

Continuous Cover Forestry (CCF) has become increasingly popular since the early 1990s. CCF utilises several silvicultural techniques in order to promote and enhance forest structural diversity and favours natural regeneration. As CCF is relatively new to the UK there are still areas of knowledge regarding management interventions that need to be improved upon. This study utilises simple models, seedling physiology and a hybrid gap model and applies them to the Glentress Trial Area which has been under transformation from even-aged forestry since 1952. These efforts have led to an improved understanding of thinning interventions and the effects they may have on future stand structure. Since the formation of the Forestry Commission in 1919, clearfell-replant forestry has been the main form of management practiced in the UK. CCF management differs in several respects and is commonly practiced using expert knowledge in Continental Europe. In the UK the knowledge-base is still growing and therefore simple models can prove useful for guiding management. This study investigated the use of the idealised reverse-J and the Equilibrium Growing Stock (EGS). This study found that the reverse-J shaped diameter distribution is maintained at the Trial, Block and sub- Block scale indicating that an irregular structure is being approached. In addition, the diminution coefficient, a parameter of the reverse-J distribution, falls within values typical of continental Europe. Comparison of the actual diameter-frequency distribution against an ideal reverse-J distribution can inform both thinning intensity and which diameter classes to target. The EGS, which is a volume–diameter distribution, examines standing volume and how that volume is distributed across three broad diameter classes. Typical distributions from the Swiss Jura indicate that percentage volume should be split 20:30:50 across diameter classes. The EGS analysis showed that standing volume in the Trial Area is much lower than European values at just 174 m3 ha-1. In addition, the classic 20:30:50 percent split was not observed. The 1990 data set showed a 49:43:8 distribution but by 2008 it was 40:41:19. As natural regeneration is favoured in CCF a better understanding of seedling physiology is essential. This study established open (15-35 m2 ha-1) and closed canopy plots (>35 m2 ha-1). Plot characteristics were recorded and then seedlings were selected for physical measurements, chlorophyll fluorescence and gas-exchange measurements. There were clear differences between the physical characteristics with a mean Apical Dominance Ratio (APR) of 1.41 for the open plots and 0.9 for the closed plots which is consistent with previous studies suggesting an APR of 1 is needed for successful regeneration. The chlorophyll fluorescence measurements showed a linear relationship with PAR. However, although the results of the gas-exchange measurements showed an increase in photosynthetic rates with PAR for open plots, there was no obvious relationship in the closed plots. As a result, the study did not find a linear relationship between photosynthetic rate and chlorophyll fluorescence. Finally a complex, hybrid gap model was used to investigate the effects of management on predicted future stand structure. The hybrid gap model, PICUS v1.41, was parameterised for Sitka spruce. The model was used to explore different management scenarios on stand structure over two time periods; 1954-2008 and 1952- 2075. The output from the group selection with underplanting scenario, which resembled the actual management, produced realistic output that was comparable to the stand characteristics measured during the 2008 assessment. The output from the 1952-2075 runs suggested that thinning to a residual basal area suitable to allow natural regeneration (<30 m2 ha-1) or a group selection with underplanting were the best management options for maintaining structural diversity.

Introduction: Little is known about the impact of spousal involvement on continuous positive airway pressure (CPAP) adherence. The aim of this study was to determine whether spouse involvement affects adherence with CPAP therapy, and how this association varies with gender. Methods: 194 subjects recruited from Apnea Positive Pressure Long Term Efficacy Study (APPLES) completed the Dyadic Adjustment Scale (DAS). The majority of participants were Caucasian (83%), and males (73%), with mean age of 56 years, mean BMI of 31 kg/m2. & 62% had severe OSA. The DAS is a validated 32-item self-report instrument measuring dyadic consensus, satisfaction, cohesion, and affectional expression. A high score in the DAS is indicative of a person’s adjustment to the marriage. Additionally, questions related to spouse involvement with general health and CPAP use were asked. CPAP use was downloaded from the device and self-report, and compliance was defined as usage > 4 h per night. Results: There were no significant differences in overall marital quality between the compliant and noncompliant subjects. However, level of spousal involvement was associated with increased CPAP adherence at 6 months (p=0.01). After stratifying for gender these results were significant only among males (p=0.03). Three years after completing APPLES, level of spousal involvement was not associated with CPAP compliance even after gender stratification. Conclusion: Spousal involvement is important in determining CPAP compliance in males in the 1st 6 months after initiation of therapy but is not predictive of longer-term adherence. Involvement of the spouse should be considered an integral part of CPAP initiation procedures. Support: HL068060

This thesis follows the design process of a back end. The purpose of this back end is to interface a radar front end, developed by Acreo Swedish ICT, and stream it’s digitalized output to a PC using Universal Serial Bus (USB) 3.0. The front end, which acts as a basis for this project, is a Frequency Modulated Continuous Wave (FMCW) radar which is connected to the back end by a header. The header connects the digitalized radar signals, together with two SPI-buses and a few GPIO pins. Thus, enabling configuration and set up of the front end board via a PC. The result of the thesis is a data acquisition board that can be used to interface with the front end. The implemented back end features an FPGA to handle the ADC data from the front end, so the board has DSP capabilities, but can also stream the raw radar data. The FPGA is connected to a USB 3.0 controller through a 32-bit parallel interface. The configuration of the front end, via the produced board, is verified in it’s functionality and can be controlled by a PC using a simple GUI. Commands are sent through the USB 3.0 controller to a front end controller which handles the communication. Since getting the hardware functional has been the main objective of the thesis, the project has been deemed to be successful. The final result is a back end radar prototype, which has the requested core hardware functionalities. In addition to this, the prototype has the capacity to act as a platform for further expanding its functionality after a hand over of the project to Acreo Swedish ICT.

Nitrite (NO2-) substrate under certain conditions can cause failure of N-removal processes relying on anaerobic ammonium oxidizing (anammox) bacteria. Detoxification of NO2- can potentially be achieved by using exogenous nitrate (NO3-). In this work, continuous experiments in bioreactors with anammox bacteria closely related to “Candidatus Brocadia caroliniensis” were conducted to evaluate the effectiveness of short NO3- additions to reverse NO2- toxicity. The results show that a timely NO3- addition immediately after a NO2- stress event completely reversed the NO2- inhibition. This reversal occurs without NO3- being metabolized as evidence by lack of any 30N2 formation from 15N-NO3-. The maximum recovery rate was observed with 5 mM NO3- added for 3 days; however, slower but significant recovery was also observed with 5 mM NO3- for 1 day or 2 mM NO3- for 3 days. Without NO3- addition, long-term NO2- inhibition of anammox biomass resulted in irreversible damage of the cells. These results suggest that a short duration dose of NO3- to an anammox bioreactor can rapidly restore the activity of NO2--stressed anammox cells. On the basis of the results, a hypothesis about the detoxification mechanism related to narK genes in anammox bacteria is proposed and discussed.