yes / This article examines recent research in molecular communications from a telecommunications system design perspective. In particular, it focuses on channel models and stateof- the-art physical layer techniques. The goal is to provide a foundation for higher layer research and motivation for research and development of functional prototypes. In the first part of the article, we focus on the channel and noise model, comparing molecular and radio-wave pathloss formulae. In the second part, the article examines, equipped with the appropriate channel knowledge, the design of appropriate modulation and error correction coding schemes. The third reviews transmitter and receiver side signal processing methods that suppress intersymbol- interference. Taken together, the three parts present a series of physical layer techniques that are necessary to producing reliable and practical molecular communications. / The work of C.-B. Chae was in part supported by the Basic Science Research Program (2014R1A1A1002186) funded by the Ministry of Science, ICT and Future Planning (MSIP), Korea, through the National Research Foundation of Korea.

Optimum filter-and-sum beamforming is useful for array systems that suffer from spatially correlated noise and interference over large bandwidth. The set of finite impulse response (FIR) filter coefficients used to implement the optimum filter-and-sum beamformer are selected to optimize signal-to-noise ratio (SNR) and reduce interference from the certain directions. However, these array systems may also be vulnerable to dispersion caused by physical components such as antennas and cables, especially when the dispersion is unequal between sensors. The unequal responses can be equalized by using FIR filters. Although the problems of optimum-SNR beamforming, interference mitigation, and per-sensor dispersion have previously been individually investigated, their combined effects and strategies for mitigating their combined effects do not seem to have been considered. In this dissertation, combination strategies for optimum filter-and-sum beamforming and sensor dispersion correction are investigated. Our objective is to simultaneously implement optimum filter-and-sum beamforming and per-sensor dispersion correction using a single FIR filter per sensor. A contribution is to reduce overall filter length, possibly also resulting in a significant reduction in implementation complexity, power consumption, and cost. Expressions for optimum filter-and-sum beamforming weights and per-sensor dedispersion filter coefficients are derived. One solution is found via minimax optimization. To assess feasibility, the cost is analyzed in terms of filter length. These designs are considered in the context of LWA1, the first ``station'' of the Long Wavelength Array (LWA) radio telescope, consisting of 512 bowtie-type antennas and operating at frequencies between 10 MHz and 88 MHz. However, this work is applicable to a variety of systems which suffer from non-white spatial noise and directional interference and are vulnerable to sensor dispersion; e.g., sonar arrays, HF/VHF-band riometers, radar arrays, and other radio telescopes. / Ph. D.

Small size, light weight, high efficacy, longer lifetime and controllable output are the main advantages of high-frequency electronic ballasts for gas discharge lamps. However, power line quality and electromagnetic interference (EMI) issues arise when a simple peak rectifying circuit is used. To suppress harmonic currents and improve power factor, input-current-shaping (ICS) or power-factor-correction (PFC) techniques are necessary. This dissertation addresses advanced high-frequency electronic ballasting techniques by using a single-stage PFC approach. The proposed techniques include single-stage boost-derived PFC electronic ballasts with voltage-divider-rectifier front ends, single-stage PFC electronic ballasts with wide range dimming controls, single-stage charge-pump PFC electronic ballasts with lamp voltage feedback, and self-oscillating single-stage PFC electronic ballasts. Single-stage boost-derived PFC electronic ballasts with voltage-divider-rectifier front ends are developed to solve the problem imposed by the high boost conversion ratio required by commonly used boost-derived PFC electronic ballast. Two circuit implementations are proposed, analyzed and verified by experimental results. Due to the interaction between the PFC stage and the inverter stage, extremely high bus-voltage stress may exist during dimming operation. To reduce the bus voltage and achieve a wide-range dimming control, a novel PFC electronic ballast with asymmetrical duty-ratio control is proposed. Experimental results show that wide stable dimming operation is achieved with constant switching frequency. Charge-pump (CP) PFC techniques utilize a high-frequency current source (CS) or voltage source (VS) or both to charge and discharge the so-called charge-pump capacitor in order to achieve PFC. The bulky DCM boost inductor is eliminated so that this family of PFC circuits has the potential for low cost and small size. A family of CPPFC electronic ballasts is investigated. A novel VSCS-CPPFC electronic ballast with lamp-voltage feedback is proposed to reduce the bus-voltage stress. This family of CPPFC electronic ballasts are implemented and evaluated, and verified by experimental results. To further reduce the cost and size, a self-oscillating technique is applied to the CPPFC electronic ballast. Novel winding voltage modulation and current injection concepts are proposed to modulate the switching frequency. Experimental results show that the self-oscillating CS-CPPFC electronic ballast with current injection offers a more cost-effective solution for non-dimming electronic ballast applications. / Ph. D.

The current cardiac computed tomography (CT) technology is mainly limited by motion blurring and radiation dose. The conceptual multi-source interior CT scheme has provided a potential solution to reduce motion artifacts and radiation exposure. This dissertation work conducted multi-facet investigations on a novel multi-source interior CT architecture (G. Cao, et. al, IEEE Access, 2014;2:1263-71) which employs distributed stationary multi-beam Carbon-nanotube (CNT) X-ray sources and simultaneously operates multiple source-detector chains to improve temporal resolution. The collimation based interior CT is integrated in each imaging chain, to suppress radiation dose. The central thesis statement is: Compared to conventional CT design, this distributed source array based multi-source interior CT architecture shall provide ultra-fast CT scan of region-of-interest (ROI) inside body with comparable image quality at lower radiation dose. Comprehensive studies were conducted to separately investigate three critical aspects of multi-source interior CT: interior CT mode, X-ray scattering, and scatter correction methods. First, a single CNT X-ray source based interior micro-CT was constructed to serve as a down-scaled experimental verification platform for interior CT mode. Interior CT mode demonstrated comparable contrast-noise-ratio (CNR) and image structural similarity to the standard global CT mode, while inducing a significant radiation dose reduction (< 83.9%). Second, the data acquisition of multi-source interior CT was demonstrated at clinical geometry, via numerical simulation and physical experiments. The simultaneously operated source-detector chains induced significant X-ray forward / cross scattering and thus caused severe CNR reduction (< 68.5%) and CT number error (< 1122 HU). To address the scatter artifacts, a stationary beam-stopper-array (BSA) based and a source-trigger-sequence (STS) based scatter correction methods were proposed to enable the online scatter measurement / correction with further radiation dose reduction (< 50%). Moreover, a deterministic physics model was also developed to iteratively remove the scatter-artifacts in the multi-source interior CT, without the need for modifications in imaging hardware or protocols. The three proposed scatter correction methods improved CNR (< 94.0%) and suppressed CT number error (< 48 HU). With the dedicated scatter correction methods, the multi-source interior CT could provide ROI-oriented imaging with acceptable image quality at significantly reduced radiation dose. / Ph. D.

<p dir="ltr">Functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) via MRI are powerful, noninvasive methods for imaging of the human brain. Here, two studies are presented which explore algorithm development for the processing and analysis of fMRI and DTI-MRI data.</p><p dir="ltr">In the first study, brain functional connectivity was analyzed in a cohort of high school American football athletes over a single play season and compared against participants in non-collision high school sports. Football athletes underwent four resting-state functional magnetic resonance imaging sessions: once before (pre-season), twice during (in-season), and once 34–80 days after the contact activities play season ended (post-season). For each imaging session, functional connectomes (FCs) were computed for each athlete and compared across sessions using a metric reflecting the (self) similarity between two FCs. HAEs were monitored during all practices and games throughout the season using head-mounted sensors. Relative to the pre-season scan session, football athletes exhibited decreased FC self-similarity at the later in-season session, with apparent recovery of self-similarity by the time of the post-season session. In addition, both within and post-season self-similarity was correlated with cumulative exposure to head acceleration events. These results suggest that repetitive exposure to HAEs produces alterations in functional brain connectivity and highlight the necessity of collision-free recovery periods for football athletes.</p><p dir="ltr">In the second study, a method for harmonization of DTI-MRI data across sites was assessed. Pooling of data from multiple sites is limited by noise characteristics of individual scanners and their receive chain elements (e.g., coils, filters, algorithms), requiring careful consideration of methods to harmonize multisite data. Here, the ComBat data harmonization method was assessed on DTI-MRI data to determine if the harmonizing transformation produced by the algorithm could be transferred to harmonize new subject data from previously-observed sites without necessitating reharmonization of pre-existing data. Results indicated that this transferable ComBat methodology (T-ComBat) yielded reduced differences in fractional anisotropy and mean diffusivity across sites when compared with unharmonized data but did not fully reach the performance of ComBat applied to the entire dataset. Results of this study provide guidelines for circumstances (namely, the proportion of subjects one may wish to add to an existing dataset) under which T-ComBat may be effectively applied to harmonize new subject DTI-MRI data.</p>

Yes / Purpose To determine whether dizziness and falls rates change due to routine cataract surgery and to determine the influence of spectacle type and refractive factors. Methods Self-reported dizziness and falls were determined in 287 patients (mean age of 76.5 ± 6.3 years, 55% females) before and after routine cataract surgery for the first (81, 28%), second (109, 38%) and both eyes (97, 34%). Dizziness was determined using the short-form of the Dizziness Handicap Inventory. Six-month falls rates were determined using self-reported retrospective data. Results The number of patients with dizziness reduced significantly after cataract surgery (52% vs 38%; χ2 = 19.14, p < 0.001), but the reduction in the number of patients who fell in the 6-months post surgery was not significant (23% vs 20%; χ2 = 0.87, p = 0.35). Dizziness improved after first eye surgery (49% vs 33%, p = 0.01) and surgery on both eyes (58% vs 35%, p < 0.001), but not after second eye surgery (52% vs 45%, p = 0.68). Multivariate logistic regression analyses found significant links between post-operative falls and change in spectacle type (increased risk if switched into multifocal spectacles). Post-operative dizziness was associated with changes in best eye visual acuity and changes in oblique astigmatic correction. Conclusions Dizziness is significantly reduced by first (or both) eye cataract surgery and this is linked with improvements in best eye visual acuity, although changes in oblique astigmatic correction increased dizziness. The lack of improvement in falls rate may be associated with switching into multifocal spectacle wear after surgery. / This work was supported by The Dunhill Medical Trust(grant number SA14/0711).

Yes / This article reviews the literature on how blurred vision contributes to falls, gait, and postural control and discusses how these are influenced by spectacle correction. Falls are common and represent a very serious health risk for older people. They are not random events as studies have shown that falls are linked to a range of intrinsic and extrinsic risk factors. Vision provides a significant input to postural control in addition to providing information about the size and position of hazards and obstacles in the travel pathway and allows us to safely negotiate steps and stairs. Many studies have shown that reduced vision is a significant risk factor for falls. However, randomized controlled trials of optometric interventions and cataract surgery have not shown the expected reduction in falls rate, which may be due to magnification changes (and thus vestibuloocular reflex gain) in those participants who have large changes in refractive correction. Epidemiological studies have also shown that progressive addition lens and bifocal wearers are twice as likely to fall as non-multifocal wearers, laboratorybased studies have shown safer adaptive gait with single-vision glasses than progressive addition lenses or bifocals, and a randomized controlled trial has shown that an additional pair of distance vision single-vision glasses for outdoor use can reduce falls rate. Clinical recommendations to help optometrists prevent their frail, older patients from falling are suggested. / Grant support: Atkinson Charitable Foundation, College of Optometrists, Dunhill Medical Trust, Essilor International R&D, Federation of Ophthalmic & Dispensing Opticians, Health & Welfare Canada, Health Foundation, National Institute for Health Research, PPP Foundation, and Vicon Motion Systems Ltd.

<p>Density functional theory is a formally exact theory to describe ground state properties due to the existence of the exact functional. In practice, the usefulness of density functional theory relies on the accuracy of density functional approximations. After decades of effort of functional developments, the present-day state-of-the-art density functional approximations have achieved reasonably good accuracy for small systems. However, the error grows with system size. One of the dominant errors intrinsic in the mainstream density functional approximations is the delocalization error, which arises because of the violation of Perdew-Parr-Levy-Balduz (PPLB) linearity condition. The PPLB condition governs the formulation of the density functional theory for fractional-charge systems, for which the ground state energy for the exact functional, as a function of the fractional electron number, should yield a series of line-segments across the integer points. In this dissertation, by imposing the PPLB condition in a local, size-consistent way, we develop the local scaling correction (LSC) and its updated version, the localized orbital scaling correction (LOSC), which largely improve upon the mainstream density functional approximations across system sizes. With the LOSC, we open a door towards a systematic elimination of delocalization error. Besides the ground state functional development, we also develop a gentlest ascent dynamics approach for accessing the excited states via time-independent ground state density functionals. This is also useful for exploring Kohn-Sham energy landscapes of approximate density functionals. I will also review the PPLB formulation of density functional theory for fractionally charged systems, and show that it is equivalent to the formulation normally used for fractional system calculations under certain assumptions. Furthermore, I will examine the behavior of the fractional system energy as a function of the fractional number of electrons for different mainstream functionals, and relate it to their errors for integer systems.</p> / Dissertation

Nous avons proposé nanocode bloc simple pour assurer la fiabilité des communications nano. Nous proposons également la compression d'image simple, efficace de l'énergie pour les communications nano. Nous étudions les performances des méthodes proposées en termes d'efficacité énergétique, le taux d'erreur binaire et de robustesse contre les erreurs de transmission. Dans la compression d'image pour les communications nano, nous comparons notre méthode proposée SEIC avec compression standart images des méthodes telles que JPEG, JPEG 2000, GIF et PNG. Les résultats montrent que notre méthode proposée surpasse les méthodes de compression d'image standard dans la plupart des indicateurs. Dans la compression d'erreur pour les communications nano, nous proposons nanocode de simple bloc (SBN) et comparer la performance avec le code de correction d'erreur existant pour nanocommunication, tels que Canal Minimum Energy (MEC) et le faible poids de la Manche (LWC) codes. Le résultat montre que notre méthode proposée surpasse MEC et LWC en termes de fiabilité et de la complexité du matériel. / We proposed nanocode single block to ensure the reliability of nano communications. We also offer the simple image compression, power efficient for nano communications. We study the performance of the proposed methods in terms of energy efficiency, bit error rate and robustness against transmission errors. In image compression for nanocommunications, we compare our proposed method SEIC with standart compression image methods such as JPEG, JPEG 2000, GIF and PNG. The results show that our proposed method outperforms standard image compression methods in most metrics. In error compression for nanocommunications, we propose simple block nanocode (SBN) and compare the performance with existing error correction code for nanocommunication, such as Minimum Energy Channel (MEC) and Low weight Channel (LWC) codes. The result show that our proposed method outperforms MEC and LWC in terms of reliability and hardware complexity.

Le xeroderma pigmentosum (XP) est une maladie génétique rare caractérisée par une hypersensibilité aux ultraviolets (UV) et une forte incidence des tumeurs cutanées. Les cellules des patients XP sont incapables d’éliminer les lésions induites dans l’ADN par les UV en raison d’un dysfonctionnement du mécanisme de réparation par excision de nucléotides (NER). Plusieurs groupes de complémentation ont été identifiés dans le syndrome XP, parmi lesquels le groupe XP-C représente la majorité des patients à travers le monde.Au cours de mon travail de thèse, j’ai développé un modèle de correction ciblée par recombinaison homologue (RH) d’une délétion de deux nucléotides au niveau de l’exon 9 du gène XPC aboutissant à l’apparition prématurée d’un codon stop. Afin de stimuler la RH, deux types de nucléases ingéniérées sont utilisées : les méganucléases et les TALENs. J’ai observé que la méthylation de la séquence ciblée pouvait affecter l’activité de celles-ci et donc l’efficacité du ciblage de gène. Cependant, deux approches ont été développées pour résoudre ce problème : l’utilisation d’un agent déméthylant (5-aza-2’-désoxycytidine (5azadC)) ou la création d’une endonucléase insensible à la méthylation. L’utilisation des méganucléases en combinaison avec la 5azadC a permis de stimuler la fréquence de coupure de presque 20 fois dans des fibroblastes XPC et la TALEN modifiée permet une augmentation de 40 fois. Avec ces deux stratégies j’ai obtenu des événements de correction génétique par introduction d’une matrice de réparation dans le locus ciblé avec une fréquence proche de 3%. La caractérisation des clones corrigés avec la TALEN XPC montre la correction génomique des deux nucléotides dans l’exon 9, une restauration de l’expression de la protéine XPC et une résistance cellulaire après irradiation UV traduisant le rétablissement des fonctions de la NER. Cette étude représente la première preuve de correction génétique de cellules déficientes en protéine XPC en utilisant une approche ciblée. / Xeroderma pigmentosum (XP) is a rare inherited genetic disorder characterized by an UV hypersensitivity and a severe predisposition to skin cancers. Cells from XP patients are deficient in nucleotide excision repair (NER) of UV‐induced DNA lesions. Several complementation groups have been identified in the XP syndrome and the XP-C group represents the majority of XP patients around the world. During my PhD work, I developed a model of targeted correction by homologous recombination (HR) in order to correct a deletion of two nucleotides in the ninth exon in XPC gene leading to a premature stop codon. To stimulate HR, I used two types of engineered endonucleases : meganucleases and TALEN. I observed that the target methylation status could affect the endonuclease activities and therefore XPC gene correction. Nervertheless, I developed two approaches to overcome this methylation sensitivity : use of a demethylating agent (5-aza-2-deoxycytidine (5azadC)) or a specific engineering of TALEN. Using 5azadC with meganuclease allowed to stimulate the cutting frequency by nearly 20 fold in XPC fibroblasts and the engineered TALEN allowed a 40 fold-increase in frequency. With both strategies I obtained genetic correction events by repair matrix introduction in the targeted locus with a near 3% frequency. The characterization of corrected clones with the XPC TALEN shows genomic correction in the ninth exon, a restoration of the XPC protein expression and cell survival following UV exposure, thus demonstrating fully recovered normal repair activity by NER. This study represents the first evidence of genetic correction of XPC-deficient cells by a targeted approach.