Objective – 1) To determine whether a graft of fascia lata and part of the patellar ligament, used in an extracapsular fashion from the tibial crest to the femorofabellar ligament, would eliminate abnormal cranial drawer motion in the cranial cruciate ligament (CrCL) deficient stifle 2) To determine if two new tibial suture anchor points would enhance biomechanical function of the lateral fabellar-tibial suture (FTS). Study Design – Experimental. Animals – 28 canine cadaver hind limbs. Methods – Stifles were mounted in a jig that allowed tibial rotation during loading and were tested between loads of â 65 to 80 N in caudal and cranial drawer respectively. Stifles were tested with the CrCL intact followed by one of four stabilization techniques after CrCL transection: lateral graft technique (LGT) and three FTS with different tibial anchor points. Results – Differences in cranial drawer motion (displacement) and stiffness between the LGT and standard FTS were not significant in two data sets, when compared to the intact CrCL. The FTS with the anchor point in the tibial crest showed the least displacement of all stabilization methods. Differences in stiffness were not significant between the stabilization techniques. Conclusions – Stability provided by the LGT is comparable to that of the standard FTS for the CrCL-deficient stifle in the cadaver. Altering the tibial anchor points for the FTS did not improve stiffness or result in a further decrease in cranial drawer motion. Clinical Relevance – The LGT could be used for the treatment of acute and chronic CrCL ruptures in the dog. A clinical study is recommended. / Master of Science

Fu, Sai Chuen. / Thesis (Ph.D.)--Chinese University of Hong Kong, 2013. / Includes bibliographical references (leaves 173-195). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Abstract also in Chinese; appendixes includes Chinese.

In this thesis, adaptations were made on the Hybrid Cadaveric System to accommodate new testing ramifications. The tests simulated dynamic loading (jump landings) from a 1ft. height with various degrees of valgus (fixed hamstring and quadricep forces) and various Quadricep (Q) and Hamstring (H) forces (fixed degrees of valgus) to determine how the Anterior Cruciate Ligament (ACL) and Medial Collateral Ligament (MCL) behave. The tests performed included 0Q 0H, 100Q 0H, 300Q 0H, 300Q 100H, and 5°, 15°, 25° of valgus. To determine the strain behavior of the ACL and MCL a variety of equipment was used, including electromagnetic force plate to take impact reading, cables used to create loading on the quadriceps and hamstrings, and two Differential Variance Resistance Transducers (DVRTs). These ultimately generated ACL and MCL strain allowing for a variety of strain comparisons under various circumstances. It was concluded that in a few cases there were statistically significant differences in strain for the ACL and MCL when applying various quadricep and hamstring forces (fixed valgus). It was also found that only statistical significance was present in ACL strain when comparing degrees of valgus (fixed quadricep and hamstring forces). The research concluded that muscle activation reduces strain on the ACL and MCL in these testing scenarios. It was also established that degrees of valgus effects the ACL but is negligible for the MCL. However, due to complications and variables, further testing is needed to increase accuracy and supply more definitive results. / Includes bibliography. / Thesis (M.S.)--Florida Atlantic University, 2018. / FAU Electronic Theses and Dissertations Collection

by Raymond Che Tin Li. / Thesis (M.Phil.)--Chinese University of Hong Kong, 1989. / Bibliography: leaves 149-168.

by Tsang Wai Nam. / Thesis (M.Phil.)--Chinese University of Hong Kong, 1997. / Includes bibliographical references (leaves 163-176). / ACKNOWLEDGMENTS --- p.i / ABSTRACT --- p.ii / Chapter CHAPTER 1: --- INTRODUCTION --- p.1 / Chapter CHAPTER 2: --- LITERATURE REVIEW --- p.5 / Chapter 2.1 --- ACL ANATOMY AND BIOMECHANICS --- p.5 / Chapter 2.1.1 --- Microscopic anatomy --- p.5 / Chapter 2.1.2 --- Gross anatomy --- p.6 / Chapter 2.1.3 --- Functions of ACL --- p.9 / Chapter 2.1.4 --- Kinematics of ACL --- p.10 / Chapter 2.1.5 --- Biomechanics of ACL --- p.12 / Chapter 2.2 --- ACL INJURY --- p.16 / Chapter 2.2.1 --- Epidemiology --- p.16 / Chapter 2.2.2 --- Mechanism of injury --- p.16 / Chapter 2.2.3 --- Clinical signs and symptoms of ACL injury --- p.17 / Chapter 2.2.4 --- Consequences after ACL injury --- p.18 / Chapter 2.3 --- SURGICAL TREATMENT OF ACL INJURY --- p.19 / Chapter 2.3.1 --- ACL reconstruction --- p.19 / Chapter 2.3.2 --- Healing of the graft --- p.20 / Chapter 2.4 --- REHABILITATION --- p.22 / Chapter 2.4.1 --- Rehabilitation of the ACL-deficient knee --- p.22 / Chapter 2.4.2 --- Rehabilitation of the ACL-reconstructed knee --- p.22 / Chapter 2.5 --- KINEMATIC MEASUREMENT --- p.33 / Chapter 2.5.1 --- Reasons for kinematic measurement --- p.33 / Chapter 2.5.2 --- Measurement methods --- p.33 / Chapter 2.6 --- ROENTGEN STEREOPHOTOGRAMMETRIC ANALYSIS (RSA) --- p.45 / Chapter 2.6.1 --- Plain radiographic method --- p.45 / Chapter 2.6.2 --- RSA --- p.45 / Chapter 2.6.3 --- Convergent versus Biplane x-ray methods --- p.46 / Chapter 2.7 --- VIDEO STEREOGRAPHY --- p.49 / Chapter 2.7.1 --- Kinematic studies --- p.49 / Chapter 2.7.2 --- Strain studies --- p.52 / Chapter 2.7.3 --- Errors from video camera measurement --- p.53 / Chapter 2.8 --- EXTERNAL MARKERS --- p.54 / Chapter 2.8.1 --- Skin markers --- p.55 / Chapter 2.8.2 --- Plate markers --- p.55 / Chapter 2.8.3 --- Skeletal markers --- p.56 / Chapter 2.8.4 --- Virtual markers --- p.58 / Chapter 2.9 --- ARTHROSCOPY --- p.61 / Chapter 2.10 --- RATIONALE AND SCOPE OF THE PROJECT --- p.63 / Chapter CHAPTER 3: --- INSTRUMENTATION --- p.69 / Chapter 3.1 --- RSA --- p.69 / Chapter 3.1.1 --- Biplane x-ray apparatus --- p.69 / Chapter 3.1.2 --- Internal markers and implant instrument --- p.70 / Chapter 3.1.3 --- Plexi-glass calibration box --- p.71 / Chapter 3.1.4 --- Transparent digitizer and computer --- p.72 / Chapter 3.1.5 --- Accuracy of the RSA --- p.74 / Chapter 3.2 --- MOUNTING JIGS AND FORCE APPLICATION SYSTEM --- p.74 / Chapter 3.3 --- VIDEO STEREOGRAPHY --- p.76 / Chapter 3.3.1 --- PEAK motion measurement system --- p.76 / Chapter 3.3.2 --- External markers --- p.79 / Chapter 3.3.3 --- Calibration frame --- p.81 / Chapter 3.4 --- ARTHROSCOPY INSTRUMENT --- p.82 / Chapter CHAPTER 4: --- METHODOLOGY --- p.84 / Chapter 4.1 --- EXPERIMENTAL SET-UP --- p.84 / Chapter 4.1.1 --- Specimens --- p.84 / Chapter 4.1.2 --- Implantation of tantalum beads into the ACL --- p.84 / Chapter 4.1.3 --- Set-up of the video motion measurement system and x-ray --- p.86 / Chapter 4.1.4 --- Mounting of cadaveric knees --- p.88 / Chapter 4.1.5 --- Mounting of external markers --- p.88 / Chapter 4.1.6 --- Pre-conditioning --- p.89 / Chapter 4.1.7 --- Application of force --- p.89 / Chapter 4.1.8 --- X-ray and video camera capturing --- p.91 / Chapter 4.1.9 --- The conditions of ACL --- p.91 / Chapter 4.1.10 --- Digitization of x-ray images --- p.91 / Chapter 4.1.11 --- Digitization of video images --- p.92 / Chapter 4.2 --- TESTING OF INSTRUMENTATION --- p.93 / Chapter 4.2.1 --- Accuracy of the PEAK motion measurement system --- p.93 / Chapter 4.2.2 --- Reliability of the experimental set-up and migration of tantalum beads --- p.94 / Chapter 4.2.3 --- "Comparison of the x, y, and z coordinates of external markers imaged by RSA and video stereography" --- p.96 / Chapter 4.3 --- PREDICTION OF LENGTH CHANGE OF ACL --- p.96 / Chapter 4.4 --- BEHAVIOR OF ACL --- p.97 / Chapter CHAPTER 5: --- DATA ANALYSIS AND STATISTICAL METHODS --- p.98 / Chapter 5.1 --- MATHEMATICAL CALCULATION --- p.98 / Chapter 5.1.1 --- RSA calculation --- p.98 / Chapter 5.1.2 --- Determination of the length changes of ACL using RSA and video stereography --- p.102 / Chapter 5.1.3 --- Calculation of center of the external markers --- p.111 / Chapter 5.2 --- ACCURACY OF THE PEAK MOTION MEASUREMENT SYSTEM --- p.113 / Chapter 5.3 --- STATISTICAL METHODS --- p.114 / Chapter 5.3.1 --- Reliability of the experimental set-up and migration of tantalum beads / Chapter 5.3.2 --- "Comparison of the x, y, and z coordinates of external markers imaged by RSA and video stereography" --- p.114 / Chapter 5.3.3 --- Prediction of length change of ACL --- p.115 / Chapter 5.3.4 --- Behavior of ACL --- p.115 / Chapter CHAPTER 6: --- RESULT --- p.116 / Chapter 6.1 --- ACCURACY OF THE PEAK MOTION MEASUREMENT SYSTEM --- p.116 / Chapter 6.2 --- RELIABILITY OF THE EXPERIMENTAL SET-UP --- p.117 / Chapter 6.3 --- MIGRATION OF TANTALUM BEADS --- p.120 / Chapter 6.4 --- "COMPARISON OF THE X，Y, AND Z COORDINATES OF EXTERNAL MARKERS IMAGED BY RSA AND VIDEO STEREOGRAPHY" --- p.123 / Chapter 6.5 --- PREDICTION OF LENGTH CHANGE OF ACL --- p.125 / Chapter 6.6 --- BEHAVIOR OF ACL --- p.129 / Chapter 6.6.1 --- Comparison of length changes in different conditions of ACL --- p.130 / Chapter 6.6.2 --- Comparison of length changes of AM and PL bundles of ACL --- p.131 / Chapter CHAPTER 7: --- DISCUSSION --- p.132 / Chapter 7.1 --- LIMITATIONS --- p.132 / Chapter 7.2 --- VIDEO STEREOGRAPHY --- p.135 / Chapter 7.2.1 --- Accuracy of the PEAK motion measurement system --- p.135 / Chapter 7.2.2 --- Prediction of length change of ACL by video stereography --- p.138 / Chapter 7.2.3 --- External markers --- p.144 / Chapter 7.3 --- BEHAVIOR OF ACL --- p.145 / Chapter 7.3.1 --- Effect of sectioning on the behavior of ACL as measured by RSA --- p.146 / Chapter 7.3.2 --- The behavior of AM and PL bundles as measured by RSA --- p.147 / Chapter 7.3.3 --- Comparison of the RSA and video stereography systems in the study of the behavior of ACL --- p.149 / Chapter 7.4 --- SOURCES OF ERROR --- p.151 / Chapter 7.5 --- CLINICAL APPLICATIONS --- p.153 / Chapter 7.5.1 --- Suggestions to the logistic of the video stereography in in vivo --- p.153 / Chapter 7.5.2 --- Suggested clinical applications --- p.156 / Chapter 7.6 --- FUTURE STUDY --- p.158 / Chapter 7.7 --- CONCLUSIONS --- p.162 / REFERENCES --- p.163 / APPENDICES --- p.177 / Chapter 1. --- Mathematical derivations for RSA system --- p.177 / Chapter 2. --- Computer program for the RSA system: BP41 EXE --- p.186 / Chapter 3. --- Computer program to find the center of the external markers: FINDCG.EXE --- p.191 / Chapter 4. --- Data and statistical results --- p.196

Dissertation (Ph.D.)--University of Toledo, 2009. / "In partial fulfillment of the requirements for the degree of Doctor of Philosophy in Biomedical Sciences." Title from title page of PDF document. Bibliography: p. 128-144.

Thesis (Ph. D.)--Rutgers University, 2009. / "Graduate Program in Biomedical Engineering." Includes bibliographical references (p. 102-113).

Thesis (M. Phil.)--University of Hong Kong, 2001. / Includes bibliographical references (leaves 223-235).

Thesis (Ph.D.)--University of Delaware, 2009. / Principal faculty advisor: Lynn Snyder-Mackler, Dept. of Physical Therapy. Includes bibliographical references.

This is an interdisciplinary research project in which the methods of biomechanical and design engineering are focused upon a problem in orthopaedics. The anterior cruciate ligament (ACL) is the major ligament in the knee and is often torn during athletic competition as well as every day activity. The ACL is made up of two functional bundles, which help to stabilize the knee. Until recently, ACL reconstruction only replaced one of these bundles; however, research shows that both bundles should be replaced to more fully restore normal knee functionality. The aim of the research was, therefore, to evaluate the mechanical aspects of the double-tunnel-double-bundle ACL reconstruction technique. The research was directed towards designing a new and improved surgical device to improve ACL reconstruction: The current study used a computational model and experimental testing to explore the mechanical parameters of the tendon graft and knee bones to investigate the effects of double tunnel drilling in tibia and femur during ACL reconstruction. The thesis presents the findings of research into three aspects of double-tunnel-double-bundle ACL reconstruction. The first aspect of the study involves clinical and computational analysis of a single-tunnel-singlebundle (SB) ACL reconstructed knee with a double-tunnel-double-bundle (DB) ACL reconstructed example. The study tried to show the advantage of the DB technique over the conventional SB technique. The anatomical geometries of both SB and DB examples were used to create a finite element model and investigate the relative merits of single and double tunnelling, the variations of graft pretension, and tunnel placement on bone stress. The experimental and computational results of both methods were compared and discussed. The second study investigated whether tripling a tendon when using suspensory fixation provides inferior graft strength and a greater cyclical elongation than a doubled tendon graft with suspensory fixation. The tensile stress was found to be lower in the third strand than in the doubled portion. The study was focussed on the mechanical assessment of two different methods of tripling tendons when using suspensory fixation. The third aspect of the study focussed on the design of a new device for fixation of the femoral tripled tendon graft in DB ACL reconstruction technique. The study describes a series of designs and prototypes that were iteratively developed and experimentally tested, leading to a novel tripled tendon graft device. The function of the new device was compared with the conventional methods and tested with a number of animal tendons and bones. The new device with a tripled tendon graft resulted in higher pull-out strength and less graft elongation than that seen using a conventional tripling method.