The Cuu Long and Nam Con Basins, offshore Vietnam, contain sediment dispersal systems, from up-dip fluvial environments to down-dip deep-water slope and basinal environments that operated along the southern continental margin of Vietnam during Pliocene to Recent time. The available data enabled sediment thickness patterns, sequence-stratigraphic relationships, and channel types (fluvial to deep-water channels) within the lower Pliocene to Recent stratigraphic succession in the Cuu Long and Nam Con Son basins of offshore Vietnam to be analyzed. At least nine sequences and their accompanying systems tracts exist in the Pliocene to Recent section. Shelf-edge development in the study area is limited to the Eastern Nam Con Son Sub-Basin. Overall south to southeastward migration of the shelf edge complex during Pliocene to Recent time indicates that the Paleo-Mekong River System was the dominant sediment source for the area.

The Cuu Long and Nam Con Basins, offshore Vietnam, contain sediment dispersal systems, from up-dip fluvial environments to down-dip deep-water slope and basinal environments that operated along the southern continental margin of Vietnam during Pliocene to Recent time. The available data enabled sediment thickness patterns, sequence-stratigraphic relationships, and channel types (fluvial to deep-water channels) within the lower Pliocene to Recent stratigraphic succession in the Cuu Long and Nam Con Son basins of offshore Vietnam to be analyzed. At least nine sequences and their accompanying systems tracts exist in the Pliocene to Recent section. Shelf-edge development in the study area is limited to the Eastern Nam Con Son Sub-Basin. Overall south to southeastward migration of the shelf edge complex during Pliocene to Recent time indicates that the Paleo-Mekong River System was the dominant sediment source for the area.

L'importation de ARNtLys CUU (tRK1) de levure dans les mitochondries humaines indique que la cellule humaine possède la machinerie pour importation d'ARNt. Dans la présente étude, nous montrons que le précurseur de la lysyl-ARNt synthétase mitochondriale peut interagir avec tRK1 et ses dérivés contenant les déterminants d'import mitochondrial, et facilite leur internalisation par les mitochondries humaines. L'efficacité de l'importation augmentait à l'addition de l'énolase, d'enzyme glycolytique fonctionnant comme ARN chaperon. La translocation de tRK1 et de ses dérivés dans la matrice mitochondriale dépend également d'une autre protéine, la polynucléotide phosphorylase (PNPase). Mutation ponctuelle pathogénique qui prévient la trimérisation de PNPase diminue l'importation des ARNr 5S et ARN MRP dans les mitochondries ceci affectant la traduction mitochondriale. La surexpression de PNPase induit une augmentation des ARN importé et complémente le déficit de traduction mitochondriale. / The import of yeast tRNALys (tRK1) into human mitochondria in the presence of cytosolic extract suggests that human cell possesses machinery for tRK1 import. Here, we show that precursor of mitochondrial lysyl-tRNA synthetase (preKARS2) interact with tRK1 and its derivatives containing tRK1 import determinants, and facilitates their import into isolated mitochondria and in vivo, when preKARS2 was overexpressed or downregulated. tRK1 import efficiency increased upon addition of glycolytic enzyme enolase, previously found as an actor of RNA import in yeast. We found that tRK1 and its derivatives translocate into mitochondrial matrix in polynucleotide phosphorylase (PNPase) dependent manner. Furthermore, a point mutation preventing trimerization of PNPase affect import of 5S rRNA and MRP RNA into mitochondria and subsequently mitochondrial translation. Overexpression of the wild-type PNPase induced an increase of 5S rRNA import into mitochondria and rescued translation.