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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
81

Cytokine production by cultured bovine mammary epithelial cells (MAC-T) upon stimulation with lipopolysaccharide

Chan-Tang, Hoi-Sing. January 1998 (has links)
Cytokines are known to be involved in mastitis, yet their production by bovine epithelial cells has so far not been reported. In this research a bovine mammary alveolar cell line (MAC-T) was used as a simplified model for mammary glands. Cultured MAC-T cells were stimulated with 1, 10 and 20 mug/ml of a bacterial cell wall component (lipopolysaccharide) to verify the production of epithelially derived bovine cytokines. Cytokine mRNA production was assessed by reverse transcriptase polymerase chain reaction (RT-PCR) using RNA samples isolated during the first 24 hrs of lipopolysaccharide stimulation. Interleukin-1alpha/beta, interleukin-6 and interleukin-8 mRNA production seemed to be time and dose dependent. Restriction enzyme analysis of PCR products confirmed the identity of the cytokines. Enzyme linked immunosorbent assays for interleukin-1 and interleukin-8 showed that the respective mRNA's were translated into proteins. Interleukin-8 protein was detectable 6 hrs after lipopolysaccharide stimulation; maximal levels of approximately 55 pg/ml were reached at 48 hrs post stimulation. Interleukin-1 was detected 1hr after stimulation; concentrations peaked between 500 and 600 pg/ml at 2, 5 and 12 hrs for 20, 10 and 1 mug/ml of lipopolysaccharide respectively. The amount of protein produced by the MAC-T cell line was relatively low and required high concentrations of lipopolysaccharide. Nevertheless, this model demonstrated a time and dose dependent cytokine production. These results suggest that bovine epithelial cells could be a source of cytokine production during mammary infection.
82

Activating point mutations in the common ?gb?s[beta]-subunit of the human GM-CSF, IL-3 and IL-5 receptors : implications for receptor function and role in disease / by Brendan John Jenkins.

Jenkins, Brendan John January 1998 (has links)
Includes bibliographical references (17 leaves) / vii, 113, [89] leaves, [32] leaves of plates : ill. (some col.) ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Generates and exploits activating point mutations in the common ?gb?s subunit (h?gb?sc) of the human GM-CSF, IL-3 and IL-5 receptors. Elucidates the mechanisms by which the isolated mutations confer constitutive activity on h?gb?sc. Identifies the putative all-specific signalling molecules and provides a map of the locations of activating point mutations in h?gb?sc, / Thesis (Ph.D.)--University of Adelaide, Dept. of Medicine, 1998
83

Activating point mutations in the common ?gb?s[beta]-subunit of the human GM-CSF, IL-3 and IL-5 receptors : implications for receptor function and role in disease / by Brendan John Jenkins.

Jenkins, Brendan John January 1998 (has links)
Includes bibliographical references (17 leaves) / vii, 113, [89] leaves, [32] leaves of plates : ill. (some col.) ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Generates and exploits activating point mutations in the common ?gb?s subunit (h?gb?sc) of the human GM-CSF, IL-3 and IL-5 receptors. Elucidates the mechanisms by which the isolated mutations confer constitutive activity on h?gb?sc. Identifies the putative all-specific signalling molecules and provides a map of the locations of activating point mutations in h?gb?sc, / Thesis (Ph.D.)--University of Adelaide, Dept. of Medicine, 1998
84

Innate immune responses of the mouse and jird to filarial parasites and emulsan : a putative adjuvant /

Panilaitis, Bruce J. B. January 2001 (has links)
Thesis (Ph.D.)--Tufts University, 2001. / Adviser: Juliet A. Fuhrman. Submitted to the Dept. of Biology. Includes bibliographical references. Access restricted to members of the Tufts University community. Also available via the World Wide Web;
85

Human truncated thioredoxin (Trx80) as a novel mitogenic cytokine for white blood cells /

Pekkari, Klas, January 2001 (has links)
Diss. (sammanfattning) Stockholm : Karolinska institutet, 2001. / Härtill 5 uppsatser.
86

Activating point mutations in the common?gb?s[beta]-subunit of the human GM-CSF, IL-3 and IL-5 receptors : implications for receptor function and role in disease /

Jenkins, Brendan John. January 1998 (has links) (PDF)
Thesis (Ph. D.)--University of Adelaide, Dept. of Medicine, 1998. / Includes bibliographical references (17 leaves ).
87

Effector CD4Ê T lymphocytes in the prodrome of polyarthritis /

Brasted, Melissa. January 2001 (has links) (PDF)
Thesis (Ph.D.) -- University of Adelaide, Dept. of Molecular Biosciences, 2002. / "October 2001" Amendments (4 leaves) inserted inside back cover. Includes bibliographical references (leaves 215-266).
88

Application of proximity ligation for detection of proteins, biomolecular interactions, and single copies of pathogens /

Gustafsdottir, Sigrun Margret, January 2006 (has links)
Diss. (sammanfattning) Uppsala : Uppsala universitet, 2006. / Härtill 4 uppsatser.
89

Synthesis of cytokines and growth factors during bacterial peritonitis complicating peritoneal dialysis in vivo and in vitro studies /

Wan, Cheuk-chun. January 2008 (has links)
Thesis (M. Res.(Med.))--University of Hong Kong, 2008. / Includes bibliographical references (p. 106-130)
90

Do carbohydrates increase the magnitude of the inflammatory response

Depner, Chris Michael. January 2008 (has links) (PDF)
Thesis (MS)--Montana State University--Bozeman, 2008. / Typescript. Chairperson, Graduate Committee: Mary P. Miles. Includes bibliographical references (leaves 64-67).

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