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京都大学 / 0048 / 新制・課程博士 / 博士(人間健康科学) / 甲第21036号 / 人健博第52号 / 新制||人健||4(附属図書館) / 京都大学大学院医学研究科人間健康科学系専攻 / (主査)教授 任 和子, 教授 三谷 章, 教授 村井 俊哉 / 学位規則第4条第1項該当 / Doctor of Human Health Sciences / Kyoto University / DFAM

In a 9-month prospective study, sleep and daytime functioning were compared in a community sample of 86 participants aged 25-50 years: 43 meeting DSM IV criteria for primary insomnia (26 women & 17 men); and 43 controls (32 women & 11 men). Assessments were conducted at baseline, 4 and 8 months, and included: the Pittsburgh Sleep Quality Index; Spielberger StatefTrait Anxiety Inventory; Eysenck Personality Questionnaire, Beck Depression Inventory; Fatigue Severity Scale; SF-36; Epworth Sleepiness Scale; Dysfunctional Beliefs About Sleep Scale; Sleep Hygiene and Practices Scale, Sleep Disturbance Questionnaire and the Psychomotor Vigilance Task PVT. An instrument to assess the occupational consequences of insomnia (the Occupational Impact of Sleep Questionnaire; OISQ) was also developed in the course of the study. PWI versus control group comparisons were made with repeated measures multivariate ANOVAs. Differences were consistently and significantly maintained on measures of state (F = 15.85 P <0.001) and trait anxiety (F = 23.46; P < 0.001), depression (F = 18.37; P < 0.001), fatigue (F = 22.20; P < 0.001), and neuroticism (F = 11.09; P < 0.001). Among PWI, mental health (F = 14.04; P < 0.001), pain (F = 6.92; P < 0.001), role-emotion (F = 10.94; p < 0.001), general health perceptions (F = 4.77; P < 0.05), social functioning (F = 6.58; P < 0.01) and energy and vitality (F = 32.08; P < 0.001), on the SF-36, were consistent with inferior health related QoL. In addition, pre-sleep arousal (F = 14.76; P < 0.001), sleep hygiene (F = 35.26; P < 0.001) and sleep disturbance (F = 72.32; P < 0.001) were significantly worse within PWI. Subjectively reported TIB (F = 9.38; P < 0.01), SOL (F = 11.17; P < 0.01) and WASO (F = 21.10; P < 0.001), remained greater within PWI, with SE (F = 15.29; P < 0.001), TST (F = 9.38; P < 0.01) and subjective sleep quality (F = 29.57; P < 0.001) greater within controls. Data averaged over the duration of data collection (252 days) found PWI reported an average SOL >30 minutes, an average WASO of> 30 minutes, SE < 80%. Analysed in terms of night to night sleep quality, both PWI and controls showed a pattern of 'good' (sleep efficiency >80%) and 'poor' (sleep efficiency <80%) nights. However, the probability of individual poor nights remained consistently and significantly higher for PWI across the 9 months of the study. Actigraphy data failed to confirm between group differences in sleep, and correlation with diary measures was low in both groups. PVf performance showed instability. Significant group differences found at baseline, were no longer present at subsequent data collection points. Data support the inconsistency surrounding objective performance among PWI within the literature. However, the inconsistency can be attributed to greater change within control participant's performance, rather than within PWI. Data identified the existence of a stable subgroup of PWI reporting symptoms of daytime sleepiness. Daytime sleepiness was found to be a temporally stable feature for this sub-group of PWI, who also Showed a distinctive psychological profile compared to PWI who did not report daytime sleepiness. No difference, however, was observed in subjectively reported sleep structure, quality or daytime performance between these subgroups of PWI. Insomnia subgroup analyses suggest a trait-like difference between sleepy and non sleepy PWI.The OISO showed an acceptable level of internal consistency reliability (alpha 0.93); and successfully discriminated between PWI and controls. The OISO also showed consistent correlations with measures of global sleep quality and subjective sleep parameters. Expressed in terms of comparative percentage decrement, PWI showed a consistent 10% decrement in subjective occupational performance when compared with controls. The OISO shows that absenteeism and punctuality may not capture the full impact of insomnia on workplace performance.

We studied the global climatology of mid- and low-latitude F region daytime neutral winds using extensive measurements by the Wind Imaging Interferometer (WINDII) instrument on board the Upper Atmosphere Research Satellite (UARS). Quiet-time winds are mostly poleward and westward during the day, and are generally 5-20 m/s smaller in the longitudinal sector closest to the magnetic pole, compared to longitudinally averaged winds. The pre-noon zonal winds are less westward with increasing solar flux, while the post-noon meridional winds are less poleward . Our quiet-time results are in good agreement with the NCAR ThermosphereIonosphere- Electrodynamics General Circulation Model (TIEGCM). We computed residual winds by subtracting quiet-time values calculated along the satellite orbit, which effectively removes average measurement bias. Using these residuals, we studied the average change in the winds under disturbed conditions. The zonal disturbance winds are mostly westward, increase with latitude, and have largest values in the late afternoon sector. In general, the meridional perturbation winds are equatorward, increase linearly with latitude, and decrease from morning to afternoon hours. The zonal and meridional perturbations increase roughly linearly with Kp. We developed empirical analytical models for the disturbance winds from 60° to the equator; these model winds are in poor agreement with results from the empirical Horizontal Wind Model. There are also important discrepancies between the average perturbations winds from WINDII and TIEGCM. We studied the average time-dependent development of disturbance winds during geomagnetic storms. The onset of a storm is characterized by equatorward surges, mostly in the morning sector, that reach the equator in about 2 h. These surges lessen 5-6 h after the onset of a storm, but subsequently increase, reaching their largest values about 15 h after the start of the storm before leveling off or diminishing. Following the end of typical storms, the disturbance winds decrease quickly but oscillate for at least one 8-9 h cycle. We developed time-dependent analytical models of the disturbance winds as a function of the polar cap index at key storm time lags. Our results are consistent with predictions from theoretical models. (146 pages)

Purpose: The relationship between severity of voiding dysfunction and quality of life in children with daytime wetting was analyzed. Materials and Methods: The relationship between age, gender, severity of voiding dysfunction (measured by DVSS) and quality of life (measured by PinQ) in the child with daytime wetting was analyzed. Twenty-four children (4 males, 20 females) aged 5-10 years (x 8.17 years, SD 1.37) and their parents completed the DVSS and PinQ. Results: Parent and child total DVSS and total PinQ Scores had similar results with only a significant mean difference between the parent total DVSS scores based on gender. Only Gender with Parental Total DVSS Score (r = 0.462, p = 0.023) and Child Total DVSS Score with Parent Total DVSS Scores (r = 0.472, p = 0.020) were significant correlations. Conclusions: Results illustrate the importance of early recognition and intervention to minimize the impact daytime wetting has on the child.

No description available.

After steep declines due to overharvest and habitat loss, North American river otter (Lontra canadensis) populations have been increasing in most of the U.S. Radiotelemetry is an essential tool for understanding river otter habitat use, survival rates, and sources of mortality, which is important for successfully managing these growing populations. Surgically implanting radiotransmitters is standard for river otters, but strict requirements for the handling and transport of DEA-scheduled drugs for sedation, and the lack of accessible surgery suites, can limit researchers. My objectives were to: (1) develop a non-scheduled drug combination to sedate river otters and surgically implant intra-abdominal transmitters in a field setting, (2) determine survival rates and causes of mortality for river otters, and (3) quantify fourth order habitat selection at river otter daytime resting sites. During 2018-2020, I surgically implanted 24 river otters with transmitters in southern Illinois and monitored them via radiotelemetry to determine survival and causes of mortality. The effectiveness of the drug combination of Dexmedetomidine and Nalbuphine for chemically immobilizing river otters was tested to determine the appropriate dosage. I used homing to track river otters to 132 daytime resting sites where I described the structure used, closest water type, and distance to water; for 51 of these resting sites I also measured understory cover, overstory cover, distance to water, and presence of river otter and beaver sign. These 51 sites were paired with 1-4 random riparian locations, where I measured the same habitat variables. I then modeled habitat selection of daytime resting sites using conditional logistic regression. A combination of 0.06 mg dexmedetomidine/kg and 1.2 mg nalbuphine/kg injected intramuscularly followed by a 10-15 min induction period was sufficient to chemically immobilize river otters enough for further sedation with 1-4% isoflurane gas. Surgery in the field was successful, with only 2 sedation-related mortalities recorded. Estimated river otter survival was 0.84 ± 0.09 with no difference between males (0.83 ± 0.11) and females (0.86 ± 0.13) ( = 0, P = 0.900) and or between protected areas (0.80 ± 0.10) and harvested areas (0.83 ± 0.15) ( = 0.3, P = 0.600). Four river otters died (2 harvest, 2 unknown causes) during my study. Daytime rest sites were located in non-enclosed vegetation (n = 54) as well as enclosed sites, such as bank dens (n = 39), beaver lodges (n = 33), and wood piles (n = 6). River otters selected for greater understory cover at all sites, though enclosed sites had less understory cover than non-enclosed sites (all P ≤ 0.001). The top habitat selection model included the parameters understory cover and the beaver sign but did not include canopy cover. My study offers a novel way to sedate river otters without DEA-scheduled drugs, updates information about river otter survival, and provides new information on fourth order habitat selection at daytime resting sites.

Indiana University-Purdue University Indianapolis (IUPUI) / This paper compares two new methods for estimating daytime population against two existing models within downtown Indianapolis in Marion County, Indiana. The two existing models consist of the 2009 USA Daytime Population model created by ESRI and the LandScan Global Population Project developed by the Oak Ridge National Laboratory. A parking study of downtown Indianapolis, as prepared by the City of Indianapolis, Division of Metropolitan Development, is the basis of the first new method of estimating daytime population. The second method is a direct count of the daytime population using a methodology previously developed. Additionally, these four population estimates will be compared when applied to a scenario involving a hypothetical toxic gas plume.

名古屋大学博士学位論文 学位の種類:博士（医療技術学）（課程） 学位授与年月日:平成19年3月23日 / "Daytime polysomnography and portable recording device for diagnosis and CPAP therapy in patients with obstructive sleep apnea syndrome" Sleep and Breathing, v.11, n.2 (2007) pp.109-115 を、博士論文として提出したもの。

Obstructive sleep apnea is a chronic illness with increasing prevalence. In addition to associated cardiovascular comorbidities, obstructive sleep apnea syndrome has been linked to poor quality of life, occupational accidents, and motor vehicle crashes secondary to excessive daytime sleepiness. Although continuous positive airway pressure is the gold standard for sleep apnea treatment, its effects on quality of life are not well defined. In the current study we investigated the effects of treatment on quality of life using the data from the Apnea Positive Pressure Long-term Efficacy Study (APPLES), a randomized controlled trial of continuous positive airway pressure (CPAP) versus sham CPAP. The Calgary Sleep Apnea Quality of Life Index (SAQLI) was used to assess quality of life. Overall we found no significant improvement in quality of life among sleep apnea patients after CPAP treatment. However, after stratifying by OSA severity, it was found that long-term improvement in quality of life might occur with the use of CPAP in people with severe and possibly moderate sleep apnea, and no demonstrable improvement in quality of life was noted among participants with mild obstructive sleep apnea.