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EFFECTS OF INSULIN AND INSULIN-LIKE GROWTH FACTORS ON SATELLITE CELL PROLIFERATION IN VITRO (SOMATOMEDINS, RECEPTORS).Dodson, Michael Verne January 1985 (has links)
Primary cultures of skeletal muscle satellite cells were induced to proliferate by exposure to physiologic levels of somatomedins and pharmacologic levels of insulin. Dexamethasone inclusion in serum containing medium facilitated the ovine somatomedin (oSm) (P < 0.05), but that both were different than the proliferation induced by MSA/rIGF-II (P < 0.05). In the presence of insulin concentrations that promote maximum proliferation, addition of oSm did not produce an additive effect, whereas the addition of MSA/rIGF-II did produce a significant increase in satellite cell proliferation above that induced by insulin. A more, in depth, analysis of the interaction of MSA/rIGF-II with its satellite cell receptor under a variety of experimental conditions revealed that binding of ¹²⁵I-MSA/rIGF-II was inhibited by oSm and MSA/rIGF-II, but not by insulin. Migration, and localization of ¹²⁵I-MSA/rIGF-II-receptor complexes in 7% sodium dodecyl sulfate polyacrylamide gels suggest that these complexes are Type II IGF receptors. In addition, this receptor system of satellite cells was shown to be modulated by other hormones; notably, pre-exposure of cells with insulin increased ¹²⁵I-MSA/rIGF-II binding, while oSm, or MSA/rIGF-II preincubation decreased the binding of ¹²⁵I-MSA/rIGF-II. Therefore, the proliferative effects of MSA/rIGF-II appeared not as a consequence of MSA/rIGF-II induction of other receptor types such as the insulin, or Type I IGF receptor systems. Concommitant to the previous experimentation, oSm was further examined in an initial attempt to elucidate its biologic binding mechanism in myogenic satellite cells. Binding of ¹²⁵I-oSm was inhibited by MSA/rIGF-II, insulin and IGF-I; thus these data suggest that oSm may be the ovine analog to human IGF-I. In addition, pre-exposure of cells to MSA/rIGF-II and oSm down-regulated the ability of satellite cells to bind oSm, while only concentrations of insulin greater than 550 ng insulin had this ability. Collectively, these data support the hypothesis that somatomedins play an important role in the control of postnatal muscle growth by providing a link between these hormones and satellite cells, one of the significant target cells involved in the growth process.
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SELECTIVE FINES DESTRUCTION IN BATCH CRYSTALLIZATIONZipp, Gail Lea, 1959- January 1986 (has links)
No description available.
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EFFECTS OF CYTOKININ-CONTAINING PRODUCTS ON THE GROWTH AND PHYSIOLOGY OF LETTUCE (BURST, BENZYLADENINE)Levy, Jose Gabriel Vitoria, 1958- January 1986 (has links)
No description available.
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Export promotion in a small mineral based economy : the case of BotswanaSentsho, Joel January 2000 (has links)
No description available.
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The influence of microvascular pericytes on endothelial cell characteristics and gene expressionMcIlroy, Marie January 2003 (has links)
No description available.
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Impact of defoliating insects on Sitka spruceWilliams, David Thomas January 2001 (has links)
No description available.
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A novel human stress response gene with a potential role in induced radioprotection and cell cycle controlMcKeen, Hayley January 2003 (has links)
No description available.
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Vesicular-arbuscular mycorrhizas and plant performance in a semi-natural grasslandMcGonigle, T. P. January 1987 (has links)
No description available.
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The co-ordination of cell division and cell expansion in the root meristem of Arabidopsis thalianaRea, Robert W. January 2002 (has links)
No description available.
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Trade and industrial policies for development in a new South AfricaMhlongo, Thembinkosi January 1994 (has links)
No description available.
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