Ce mémoire traite des systèmes intégrés sur puce (System-on-Chip) à faible consommation d'énergie tels que ceux qui seront utilisés dans les équipements portables de future génération (ordinateurs de poche (PDA), téléphones mobiles). S'agissant d'équipements alimentés par des batteries, la consommation énergétique est un problème critique. Ces plateformes contiendront probablement une douzaine de coeurs de processeur et une quantité importante de mémoire embarquée. Une architecture de communication optimisée sera donc nécessaire afin de les interconnecter de manière efficace. De nombreuses architectures de communication ont été proposées dans la littérature: bus partagés, bus pontés, bus segmentés et plus récemment, les réseaux intégrés (NoC). Toutefois, à l'exception des bus, la consommation d'énergie des réseaux d'interconnexion intégrés a été largement ignorée pendant longtemps. Ce n'est que très récemment que les premières études sont apparues dans ce domaine. Cette thèse présente: - Une analyse complète de l'espace de conception des architectures de communication intégrées. Sur base de cet espace de conception et d'un état de l'art détaillé, des techniques jusqu'alors inexplorées ont pu être identifiées et investiguées. - La conception d'environnements de simulation de bas et haut niveaux permettant de réaliser des comparaisons entre différentes architectures de communication en termes de consommation énergétique et de surface. - La conception et la validation d'une architecture de communication intégrée innovante basée sur le multiplexage spatial Ce dernier point a pour ambition de démontrer qu'un réseau basé sur le multiplexage spatial (SDM) constitue une alternative intéressante aux réseaux classiques principalement basés sur le multiplexage temporel dans le contexte très spécifique des architectures de communication intégrées. Nous démontrerons la validité de la solution proposée à l'aide de campagnes de simulation de haut niveau pour divers types de trafic ainsi que des simulations de plus bas niveau. L'étude concerne successivement la conception de routers SDM, des interfaces réseau et finalement d'un réseau complet. Les avantages et inconvénients d'une telle technique seront discutés en détails.

Relatively little is known about the role of the basal ganglia and their pathways in human deglutition. Deep Brain Stimulation (DBS) is a treatment for Parkinson Disease (PD) that stimulates the subthalamic nuclei and affords us a model for examining deglutition in humans with known impairment of the basal ganglia. The purpose of this study was to examine the effects of DBS in the ON versus Off conditions on the oral and pharyngeal stages of deglutition in participants with PD. It was hypothesized that DBS in the ON condition would yield improvement in the following dependent variables: oral total composite score, pharyngeal total composite score, pharyngeal transit time, and maximal hyoid bone excursion. Statistically significant differences (improvement) were found for the pharyngeal composite score and pharyngeal transit time in the DBS ON condition. Findings of this study demonstrated that DBS in the ON condition helps to alleviate some of the bradykinesia and hypokinesia associated with PD on the pharyngeal stage of deglutition, but not the oral stage. These findings suggest that Parkinsonian swallowing dysfunction is not solely related to nigrostriatal dopamine deficiency which is purported to be the primary means of DBS alleviation of motor signs. Rather, it may be due to an additional non-dopamine related system of deglutition found in the brainstem.

With an increase in demand on deep-sea resources comes a need for appropriate and effective management of this ecosystem. The establishment of a representative network of deep-sea Marine Protected Areas offers one tool with which to address the conservation needs of the deep sea. While a number of deep-sea habitats have been identified as vulnerable to anthropogenic activities (e.g. cold-water coral reefs and sponge aggregations), poor knowledge of the distribution of these habitats hinders conservation efforts and network planning, and thus we need habitat maps. With improvements in acoustic data resolution acquired from the deep sea, and the ability to cover large areas rapidly, the use of acoustic techniques in mapping biological habitats is growing. Multibeam bathymetry and its derived terrain variables can potentially provide important information that can aid in the delineation and characterisation of biological communities. A necessary prelude to mapping is therefore the definition of biological assemblages for use as mapping units. Two megahabitat features (seamount and submarine canyons) were sampled using acoustic and ground-truthing to characterise and map the distribution of benthic assemblages. Species were identified as distinct morpho-types and catalogued, and still images quantitatively analysed. Standard multivariate community analysis was undertaken to define distinct faunal assemblage that may act as mapping units. Those clusters identified by the SIMPROF routine were taken against a set of criteria to reject/accept as robust assemblages that may be used as mapping units. Twenty two benthic assemblages or biotopes were defined from multivariate analysis of quantitative species data, 11 from the SW Approaches and 11 from Anton Dohrn Seamount, and a further one from video observations (SW Approaches). Taken against current definitions, 11 of these were considered as Vulnerable Marine Ecosystems (VME). Diversity was measured to compliment the comprehensive description of biotopes. The use of multivariate diversity indices proved better for comparing diversity of biotopes as it captures a more than one aspect of diversity of the community. Two biotopes were common to both megahabitat features, cold-water coral reef habitats, and those from Anton Dohrn Seamount were more diverse than from the SW Approaches. Modelling techniques were employed to test the relationship between biotopes and environmental and geophysical parameters, which may be used as surrogates to map VME. Generalised Additive Models of Vulnerable Marine Ecosystems revealed multibeam bathymetry and its derived parameters to be significant surrogate for mapping the distribution of some assemblages, particularly those that appear to be influenced by current regime; whilst not so well for those whose distribution is not so strongly current driven e.g. soft sediment communities. In terms of deep-sea mapping, the use of multibeam can prove a useful mapping tool if the resolution of the data is at an appropriate scale that will identify meso-scale geomorphological features, such as cliff-top mounds, that may act as proxies for occurrence of biotopes, but this relationship is still unclear. Surrogates were used to map VME across the seamount and submarine canyons, and full coverage maps were produced for all biotopes occurring on these megahabitat features.

Microphytobenthos are the dominant primary producers on estuarine mudflats playing a key role in the functioning of the ecosystem. Studies into microphytobenthic ecology have previously been limited by scale but the advent of fine scale analysis techniques (gm) as well as non-destructive sampling has enabled the system to be examined at a level not previously possible. This study examined the formation, structure and function of microphytobenthic biofilms using non-destructive (remote sensing by PAM fluorescence; fibreoptic light microprofiling) and destructive (cryo-freezing and Low temperature scanning electron microscopy) sampling. Many microphytobenthic organisms are motile and have evolved complex migratory strategies. Microphytobenthic migratory patterns are widely described but much remains to be elucidated about the controlling factors. The fluorescence parameter F015 (minimum fluorescence yield after 15 minutes dark adaptation) was used to monitor short-term changes in biomass at the sediment surface. Light, tidal state, endogeny and combinations thereof were all shown to control migration, demonstrating that predictable migratory rhythms cannot be assumed. Microscale sectioning showed that chlorophyll a was always concentrated in the top 400 gm (the photosynthetically active biomass). Clear migratory patterns were not detected using microscale sectioning therefore indicating that migration occurs over a scale < 400gm. Despite no changes in the chlorophyll a content in the surface layers, LTSEM analysis demonstrated diurnal taxonomic shifts providing circumstantial evidence that microphytobenthic cells sub-cycle at the sediment surface to optimise fitness. The light extinction co-efficient (k) of microphytobenthic biofilms significantly vaned with site, assemblage and also over time. 90% of the surface PPFD had always been attenuated by 400, and in many cases before 200. Traditional microphytobenthic primary productivity models do not account for changes in the spatial and temporal distribution of biomass or light attenuation and therefore their applicability to the real situation may be limited.

Venous thromboembolism (VTE) is a common disease with a myriad of presentation. It is often difficult to diagnosis with symptoms which are shared with many other disorders. Because of the overlap in symptomatology with other pathologies it is both commonly overlooked when present and commonly considered when absent. The threshold for investigating suspected VTE has dropped over time, in part due to a greater awareness of the disease among clinicians, but also because of the greater availability of diagnostic tests which are both accurate at positively diagnosing VTE and are patient friendly. This has resulted in a mushrooming of the number of diagnostic tests being performed for suspected VTE in radiology departments. As such radiology provides a window into the disease in a way that no other speciality can. All branches of medicine having their share of VTE patients but radiology provides a unique opportunity to study VTE patients as, no matter from which speciality they arise when the disease is suspected, they will almost inevitably end up undergoing a definitive radiological test. There is much still to learn about VTE however developments in modern imaging and computerised databases have advanced our understanding of this common disease. The window that radiology provides into VTE has contributed towards those advances.

The maximum number (Nmax) of fish was recorded using baited underwater camera (BUC) techniques to study spatio-temporal changes of the fish community in localize areas. In the central North Sea (~100m depth) abundance models revealed that for both, whiting and flatfish, the Nmax was influenced by light level at the time of deployment. Nmax of hagfish was strongly related to current speed in a non-linear way with a predicted upper threshold (~11 cm.s-1) above which Nmax declined. Current speed and inter-annual variation had an important effect on haddock Nmax. Large predators that prompt avoidance mechanisms (e.g. large conger eel, marine mammals and fishing vessels) and bottom current speed >25 cm.s-1 can modify demersal fish behaviour depending on size and species and therefore have important effects on BUC-derived data. The BUC was applied for the first time to the monitoring of the Buzzard platform, a new oil and gas development in the central North Sea that host 12 demersal and benthic fish species. The benthic taxa, flatfish and hagfish, showed higher numbers closer to the platform whilst the most mobile species showed constant numbers (haddock) or highest numbers outside of the 500m of Exclusion Area (whiting). No significant changes in fish diversity were found between the areas surveyed before the platform construction. After the construction, the species richness and diversity were higher outside the 500m Exclusion Area surrounding the platform. Offshore sand banks, like oil platforms, can modify the composition of the local fish abundance. BUC and commercial trawl observations on the Jones Bank (75-150m depth, Celtic Sea) recorded 23 species, the highest richness, on top of the bank and 18 species on the slope and off-bank areas. Conger eel and Nephrops were both absent from the top of the bank site whereas haddock was only observed in the bank area.

Development of a college level freshman biology course was undertaken in response to government reports that American students have fallen behind students of other countries in the area of the sciences. Teaching strategies were investigated to accomplish two objectives, to define essential academic material to include in the course and to investigate teaching techniques that would increase deep processing of the information. An active process that consisted of applying the cognitive information to solving problems or developing answers to questions was defined as critical thinking. Critical thinking was incorporated into the course by the use of case studies.

No description available.

Frying oil is a heat and mass transfer medium, which affects the quality of food. The reaction mechanisms in deep-frying oils are mainly thermal oxidation, hydrolysis, and polymerization, which result in lipid deterioration. Addition of synthetic or natural antioxidants can effectively slow down lipid deterioration during deep-frying. Total polar components, polymerized triglycerides, p-anisidine value, acid value and iodine value are reliable indicators for assessing oil degradation during frying. Color darkening of deep-frying oils is one of apparent changes during deep-frying and is closely associated with the levels of decomposition compounds in the frying oils. However, the evidence of the relationship between color and deep-frying oil quality indicators are scanty. The main objective of this thesis is to develop a model for rapid assessment of oil quality during 30-hour deep-frying processes using oil color and quality as indicators. Significant color changes (p < 0.05) were observed in soybean oil as compared to canola and sunflower oil during 30-hour deep-frying trials. Canolol-enriched frying oils showed the highest color values before deep-frying, but the final results showed the least color changes (p < 0.05) during the 30-hour deep-frying trials. The highest percentage of total polar components (15.55 %), polymeric triglycerides (9.3 %), and p-Anisidine value (62.34) were found in TBHQ-enriched deep-frying oil samples in soybean oil. The highest acid value (3.06 mg KOH/100g) was found in canolol-enriched frying oil samples in canola oil. Rosemary and canolol-enriched deep-frying oil samples showed significant effect (p < 0.05) on color changes while reducing formation of total polar components, polymeric triglycerides, and aldehydes during the 30-hour deep-frying study. Significant correlations (p < 0.05) were found between color and oil quality indicators in all of the deep-frying oil samples; significant regression (p < 0.05) models are expressing the level of oil deterioration from color (light-dark, red-green, yellow-blue) in deep-frying oils. Overall, this study established several models using color as an indicator aiming to rapidly assess deep-frying oil quality. / October 2016

This work focuses on diffusion and advection through cementitious media, the work arises from two research contracts undertaken at Loughborough University: Experiments to Demonstrate Chemical Containment funded by UK NDA and the SKIN project, funded by the European Atomic Energy Community's Seventh Framework Programme. Diffusion will be one of the most significant mechanisms controlling any radionuclide migration from a nuclear waste, deep geological disposal facility. Advection may also occur, particularly as the immediate post closure groundwater rebound and equilibration proceeds but is expected to be limited by effective siting and management during the operational phase of the facility. In this work advection is investigated at laboratory scale as a possible shorter timescale technique for providing insight into the much slower process of diffusion. Radial techniques for diffusion and advection have been developed and the developmental process is presented in some detail. Both techniques use a cylindrical sample geometry that allows the radionuclide of interest to be introduced into a core drilled through the centre of the test material. For diffusion the core is sealed and submerged in a container of receiving solution which is sampled and analysed as the radionuclide diffuses into it. For advection, a cell has been designed that allows inflow via the central core to pass through the sample in a radial manner and be collected as it exits from the outer surface. The radionuclide of interest can be injected directly into the central core without significant disturbance to the advective flow. Minor improvements continue to be made but both techniques have provided good quality, reproducible results. The majority of the work is concentrated on a potential cemetitious backfill known as NRVB (Nirex Reference Vault Backfill) this is a high porosity, high calcium carbonate content cementitious material. The radioisotopes used in this work are 3H (in tritiated water), 137Cs, 125I, 90Sr, 45Ca, 63Ni, 152Eu, 241Am along with U and Th salts. In addition the effect of cellulose degradation products (CDP) on radioisotope mobility was investigated by manufacturing solutions where paper tissues were degraded in water, at 80°C, in the absence of air and at high pH due to the presence of the components of NRVB. All diffusion experiments were carried out under a nitrogen atmosphere. All advection experiments were undertaken using an eluent reservoir pressurised with nitrogen where the system remained closed up to the point of final sample collection. Results for tritiated water and the monovalent ions of Cs and I were produced on a timescale of weeks to months for both diffusion and advection. The divalent ions of Sr, Ca and Ni produced results on a timescale of months to years. Variations of the experiments were undertaken using the CDP solutions. The effects of CDP were much more apparent at radiotracer concentration than the much higher radiotracer with non-active carrier, concentration. In the presence of CDP Cs, I and Ni were found to migrate more quickly; Sr and Ca were found to migrate more slowly. Additional Sr experiments were undertaken at elevated ionic strength to evaluate the effect of the higher dissolved solids content of the CDP solutions. Some of the results for HTO, Cs, I and Sr have been modelled using a simple numerical representation of the system in GoldSim to estimate effective diffusivity and partition coefficient. The diffusion model successfully produced outputs that were comparable to literature values. The advection model is not yet producing good matches with the observed data but it continues to be developed and more processes will be added as new results become available. Autoradiography has been used to visualise the radionuclide migration and several images are reproduced that show the fate of the radiotracers retained on the NRVB at the end of the experiments. As the experimental programme progressed it was clear that results could not be produced in a suitable timescale for Eu, Am U and Th. These experiments have been retained and will be monitored every six months until either diffusion is detected or the volume of receiving liquid is inadequate to ensure the NRVB is saturated.