The INK4A-ARF locus encodes two tumor suppressors; p16 and p19Arf, both of which restrain cell growth by regulating the functions of Retinoblastoma (Rb) and p53 respectively. Throughout development, p19Arf is kept at minimal levels, but under conditions of oncogenic stress, p19Arf expression is induced and its tumor suppressive activities are mediated through the stabilization of p53 or in a p53-independent manner. Introducing a point mutation (L46D) into the conserved hydrophobic domain (37-51) in p19Arf annulled ARF/CtBP2 interaction and mediated cell survival by rendering cells irresponsive to apoptosis. In vivo analysis on the percentage of lymphoma free survivals in ARFL46D/L46D mice indicated that disrupting ARF/CtBP2 binding resulted in a tumor spectrum similar to that in ARF-null mice. In this study, we characterized the functions of the hydrophobic domain of ARF in MEF cells under genotoxic stress, ultra-violet irradiation and oncogene activation. We demonstrated that cells bearing the mutation showed decreased responsiveness to H-RasV12 induced senescence consistent with p21 deficiency. We speculate that the deficit in p21 expression is possibly caused by CtBP2 repressive and oncogene -like properties.

Thesis (Ph. D.)--University of Idaho, 2006. / Abstract. "May 2006." Includes bibliographical references (leaves 191-206). Also available online in PDF format.

Thesis (M.B.A.)--Boston University / PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you. / 2031-01-01

To study the interaction between plants and insects I performed the experiments to find out the counter-defense mechanism of insects when insects were attacked by the defense protein of plants. Jasmonate (JA) is one of the most important plant hormones that is involved in plant defense mechanism. I studied to find out the components of JA signal transduction by T-DNA insertion mutant screening. In the first study, transcriptional regulation in cowpea bruchid guts during adaptation to a plant defense protease inhibitor, cowpea bruchid, when fed on a diet containing the soybean cysteine protease inhibitor soyacystatin N (scN), activates an array of counter-defense genes to adapt to the negative effects of the inhibitor and regain its normal rate of feeding and development. A collection of 1,920 cDNAs was obtained by differential subtraction with cDNAs prepared from guts of the 4th instar larvae of scNadapted (reared on scN-containing diet) and scN-unadapted (reared on regular scN-free diet) cowpea bruchids. Subsequent expression profiling using DNA microarray and northern blot analyses identified 94 transcript species from this collection that are responsive to dietary scN. The full-length cDNA of an scN-inducible cathepsin B-like cysteine protease was obtained. Its transcriptional response to scN during larval development contrasts with the pattern of the cathepsin L family, the major digestive enzymes. These results suggest cathepsin B-like cysteine proteases may play a crucial role in cowpea bruchid adaptation to dietary scN. In the second study, screening of mutants that are altered in jasmonate-regulated signal transduction pathways using Arabidopsis thaliana was performed. Mutant screening strategy using T-DNA insertion mutagenesis and AVP-LUC as a reporter enabled to find JA-signal transduction mutants of Arabidopsis thaliana, 9 underregulated mutants and 6 over-regulated mutants. 20B15 showed reduced VSP1, THI2.1 expression and increased PDF1.2 expression as compared to wild type when treated with JA. These data strongly suggested that 20B15 is a JA signaling mutant. 49R1, 49R2 and 49R3 had same T-DNA insertion site (At1g53540) and showed about 10-fold higher AVP-LUC expression level than wild type when JA was treated. Genetic analysis showed the mutation of these plants was recessive and tight linkage between mutant phenotype and T-DNA insertion in At1g53540.

This study assesses the effect of politics on economic growth in developing societies. In this study I developed and applied an augmented production function model to 69 developing countries with several political variables: regime type, institutional freedom, political freedom, political stability, and ideological base. I investigated how changes of political contexts affect economic growth by applying non-linear least squares, and cross national time series techniques to the production function defensegrowth model utilizing time series data from 1960 to 2002. The results show that the impacts of political variables on economic growth are at least as significant as the economic variables; the externality of non-military spending has positive and significant impact on economic growth in the majority of countries; and the impacts of economic and military variables and their externalities’ effects on economic growth differ with different political contexts. The main findings of the study provide guidelines to policy decision makers in evaluating their “guns”-“butter” alternatives.

First, the research reported in this thesis investigated the complex interplay of dynamic factors that comprise the business environment of the defense electronics industry (DEI) as a way of understanding the tactical marketing process. Second, it aimed to develop a tool for analyzing and assessing the performance of marketing projects, and a model for success in defense marketing. / Thesis (PhDBusinessandManagement)--University of South Australia, 2004.

"Submitted in partial fulfillment of the requirements for the degree of Master of Business Administration from the Naval Postgraduate School, December 2007." / Advisor(s): Dew, Nicholas ; Hudgens, Bryan J. "December 2007." "MBA professional report"--Cover. Description based on title screen as viewed on January 10, 2008. Includes bibliographical references (p. 87-127). Also available in print.

Thesis (LL. M.)--Judge Advocate General's School, United States Army, 1975. / "April 1975." Typescript. Includes bibliographical references. Also issued in microfiche.

Thesis (M.A. in Security Studies (Homeland Security And Defense))--Naval Postgraduate School, March 2009. / Thesis Advisor(s): Rollins, John ; Supinski, Stanley. "March 2009." Description based on title screen as viewed on April 23, 2009. Author(s) subject terms: Preparedness, civil defense, children, K-12 curricula, citizen preparedness, Homeland Security. Includes bibliographical references (p. 99-107). Also available in print.

Thesis--Bern. / Includes bibliographical references (p. ix-xii).