Spelling suggestions: "subject:"epidermal papillary""
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Investigations into the roles of potassium channels in hair growth. Studies confirming the presence of several ATP-sensitive potassium (K+ATP) channels in hair follicles and exploring their mechanism of action using molecular biological, cell culture, organ culture and proteomic approaches.Zemaryalai, Khatera January 2010 (has links)
Hair disorders cause significant distress. The main, but limited, treatment for hair
loss is minoxidil, an ATP-sensitive potassium (KATP) channel opener whose
mechanism of stimulation is unclear. The regulatory component of KATP channels
has three forms: SUR1, SUR2A and SUR2B which all respond to different molecules.
Minoxidil only opens SUR2B channels, though SUR1 and SUR2B are present in
human hair follicles.
To expand our understanding, the red deer hair follicle model was used initially.
Deer follicles expressed the same KATP channel genes as human follicles when
growing (anagen), but no channels were detected in resting follicles. This
reinforces the importance of KATP channels in active hair growth and the usefulness
of the deer model. To assess whether SUR1 KATP channels are actually involved in
human hair growth, the effects of a selective SUR1 channel opener, NNC55-9216,
on scalp follicle growth in organ culture was examined. NNC55-9216
stimulated anagen; its effect was augmented by minoxidil. This creates the
potential for more effective pharmaceuticals to treat hair loss via SUR1 channels,
either alone or in combination with minoxidil.
The dermal papilla plays a crucial regulatory role in hair follicle activity
determining the type of hair produced. Minoxidil had no effect on dermal papilla
cell proliferation, but altered the profile of proteins produced when assessed by
proteomics. Further research into the roles of KATP channels and greater
understanding of the significance of these protein changes should enhance our
knowledge of hair biology and help the development of new, improved therapies
for hair pathologies.
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De Novo Hair Morphogenesis in Engineered Skin SubstitutesSriwiriyanont, Penkanok 26 October 2012 (has links)
No description available.
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The role of Ten Eleven Translocation enzymes in the hair follicle mesenchymeAhmed, Aqib January 2022 (has links)
Epigenetic mechanisms play an important role during the morphogenesis
of the hair follicle and the hair cycle. Work on hair regeneration is of
importance as no products are available which can provide complete
reversal of hair loss. Tet2 promotes DNA demethylation by the
hydroxylation of 5mC to 5hmC which in turn causes gene transcription
activation. Dermal papilla (DP) cells located within the hair follicle are
responsible for the regulation of development and the growth of hair
follicles. Fgf20 signalling controls commitment of the mesenchymal
precursor cells to the DP progenitor lineage. An immature DP cells is then
formed during maturation by Shh signalling which then stimulates these to
differentiate into a DP cell by BMP and Wnt signalling.
Methylated DNA can be bound by the proteins recruiting transcription corepressors.
DNA methyltransferases (DNMT’s) can be degraded by
decitabine which reverses gene silencing. Conditional knockout of Tet2 in
mouse DP cells results in a delay in anagen initiation, suggesting Tet2 is
involved in the telogen-anagen transition. Additionally, by using dermal
fibroblasts and RA-DPAC (Dermal Papilla activating medium
supplemented with retinoic acid), it was found that decitabine can increase
plasticity in dermal fibroblasts and RA-DPAC can be used to accelerate a
lineage change to DP cells which is supported by the significant increase in the DP specific gene expression. Examples include AlPl, LEF1,
BMP4/6/7, FGF10, BMPR1A and PDGFA. Additionally, by way of siRNA
and conditional Tet2 knockout data in dermal fibroblasts, it was found Tet2
regulates signature DP genes such as Bmpr1a, ALPL, Tcf4 and SOX2.
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Investigations into the roles of potassium channels in hair growth : studies confirming the presence of several ATP-sensitive potassium (K+ATP) channels in hair follicles and exploring their mechanism of action using molecular biological, cell culture, organ culture and proteomic approachesZemaryalai, Khatera January 2010 (has links)
Hair disorders cause significant distress. The main, but limited, treatment for hair loss is minoxidil, an ATP-sensitive potassium (KATP) channel opener whose mechanism of stimulation is unclear. The regulatory component of KATP channels has three forms: SUR1, SUR2A and SUR2B which all respond to different molecules. Minoxidil only opens SUR2B channels, though SUR1 and SUR2B are present in human hair follicles. To expand our understanding, the red deer hair follicle model was used initially. Deer follicles expressed the same KATP channel genes as human follicles when growing (anagen), but no channels were detected in resting follicles. This reinforces the importance of KATP channels in active hair growth and the usefulness of the deer model. To assess whether SUR1 KATP channels are actually involved in human hair growth, the effects of a selective SUR1 channel opener, NNC55-9216, on scalp follicle growth in organ culture was examined. NNC55-9216 stimulated anagen; its effect was augmented by minoxidil. This creates the potential for more effective pharmaceuticals to treat hair loss via SUR1 channels, either alone or in combination with minoxidil. The dermal papilla plays a crucial regulatory role in hair follicle activity determining the type of hair produced. Minoxidil had no effect on dermal papilla cell proliferation, but altered the profile of proteins produced when assessed by proteomics. Further research into the roles of KATP channels and greater understanding of the significance of these protein changes should enhance our knowledge of hair biology and help the development of new, improved therapies for hair pathologies.
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