1 |
Investigations into the roles of potassium channels in hair growth. Studies confirming the presence of several ATP-sensitive potassium (K+ATP) channels in hair follicles and exploring their mechanism of action using molecular biological, cell culture, organ culture and proteomic approaches.Zemaryalai, Khatera January 2010 (has links)
Hair disorders cause significant distress. The main, but limited, treatment for hair
loss is minoxidil, an ATP-sensitive potassium (KATP) channel opener whose
mechanism of stimulation is unclear. The regulatory component of KATP channels
has three forms: SUR1, SUR2A and SUR2B which all respond to different molecules.
Minoxidil only opens SUR2B channels, though SUR1 and SUR2B are present in
human hair follicles.
To expand our understanding, the red deer hair follicle model was used initially.
Deer follicles expressed the same KATP channel genes as human follicles when
growing (anagen), but no channels were detected in resting follicles. This
reinforces the importance of KATP channels in active hair growth and the usefulness
of the deer model. To assess whether SUR1 KATP channels are actually involved in
human hair growth, the effects of a selective SUR1 channel opener, NNC55-9216,
on scalp follicle growth in organ culture was examined. NNC55-9216
stimulated anagen; its effect was augmented by minoxidil. This creates the
potential for more effective pharmaceuticals to treat hair loss via SUR1 channels,
either alone or in combination with minoxidil.
The dermal papilla plays a crucial regulatory role in hair follicle activity
determining the type of hair produced. Minoxidil had no effect on dermal papilla
cell proliferation, but altered the profile of proteins produced when assessed by
proteomics. Further research into the roles of KATP channels and greater
understanding of the significance of these protein changes should enhance our
knowledge of hair biology and help the development of new, improved therapies
for hair pathologies.
|
2 |
Investigations into the roles of potassium channels in hair growth : studies confirming the presence of several ATP-sensitive potassium (K+ATP) channels in hair follicles and exploring their mechanism of action using molecular biological, cell culture, organ culture and proteomic approachesZemaryalai, Khatera January 2010 (has links)
Hair disorders cause significant distress. The main, but limited, treatment for hair loss is minoxidil, an ATP-sensitive potassium (KATP) channel opener whose mechanism of stimulation is unclear. The regulatory component of KATP channels has three forms: SUR1, SUR2A and SUR2B which all respond to different molecules. Minoxidil only opens SUR2B channels, though SUR1 and SUR2B are present in human hair follicles. To expand our understanding, the red deer hair follicle model was used initially. Deer follicles expressed the same KATP channel genes as human follicles when growing (anagen), but no channels were detected in resting follicles. This reinforces the importance of KATP channels in active hair growth and the usefulness of the deer model. To assess whether SUR1 KATP channels are actually involved in human hair growth, the effects of a selective SUR1 channel opener, NNC55-9216, on scalp follicle growth in organ culture was examined. NNC55-9216 stimulated anagen; its effect was augmented by minoxidil. This creates the potential for more effective pharmaceuticals to treat hair loss via SUR1 channels, either alone or in combination with minoxidil. The dermal papilla plays a crucial regulatory role in hair follicle activity determining the type of hair produced. Minoxidil had no effect on dermal papilla cell proliferation, but altered the profile of proteins produced when assessed by proteomics. Further research into the roles of KATP channels and greater understanding of the significance of these protein changes should enhance our knowledge of hair biology and help the development of new, improved therapies for hair pathologies.
|
3 |
Structure and function of K<SUB>ATP</SUB>-channels in inspiratory neurons of mice / Struktur und Funktion von K<SUB>ATP</SUB>-Kanälen in inspiratorischen Neuronen der MausHaller, Mirjam 27 April 2000 (has links)
No description available.
|
Page generated in 0.0237 seconds