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Hipotireoidismo em c?es dermatopatas: aspectos cl?nicolaboratoriais comparados ao exame histopatol?gico da pele. / Hypothyroidism in dogs with skin diseases: clinical and laboratory aspects compared to histological examination.Teixeira, Roberto dos Santos 31 January 2008 (has links)
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Previous issue date: 2008-01-31 / This study was held at the Dermatology sector of the veterinarian clinic Animalia Rio de Janeiro RJ,
from August 1998 to December 2005, 19,7% of the total amount of dogs treated at the clinic(4107) were
guided to the Dermatology practice. A number of 266 (6.5%) animals were diagnosed with
hypothyroidism. All 100% of the subjects had skin or coat disorders; moreover, 35.7% also had non
cutaneous clinical signs of hypothyroidism. The most common dermatopathies were hair coat disorders
(65.8%) and keratinization disorders (46.6%). The more repeated non cutaneous clinical signs in the
study were metabolic disorders (19.6%) and reproductive (19.2%). The diagnosis of the disease was
confirmed dosing the thyroid hormone and TSH (18%), biopsy and histopathology of the skin (35.3%)
also by the association of both procedures (46.7%). Within these last group of animals , the
histopathology was considered as the most efficient diagnosis method for hypothyroidism (97.6% /
98.2%) as for the Hormone tests the efficiency of this diagnosis was less expressive: T4 Free (72.7% /
75.8%) e T4 Total (77.8% / 73.9%). A percentage of 68,5% of the animals with hypothyroidism , had 1
or 2 secondary diseases or associated to the endocrinopathy, from which immune mediated disorders
(45,9%) were accentuated . 157 of the diagnosed patients were submitted to treatment, with positive
results in 93.6% of the cases. The disease was most found in females (57,9%). Dogs from 1 to 8 years
old (81,6%) represented the age range of the affected animals. There were 43 breeds of dogs involved in
the study, from which Chow Chow, Shar pei and English Cocker Spaniel were considered to have
predisposition for the disease. / Este estudo foi realizado no setor de Dermatologia da Cl?nica Veterin?ria Anim?lia Rio de Janeiro
RJ, no per?odo de agosto de 1998 a dezembro de 2005. Do total de c?es atendidos na cl?nica (4107),
19,7% foram encaminhados ao setor, e em 266 destes (6,5%) foi diagnosticado hipotireoidismo. Em
todos os c?es foram observadas altera??es na pele, enquanto que, 35,7% tinham tamb?m sintomas
cl?nicos n?o cut?neos do hipotireoidismo. As dermatopatias mais comuns foram os dist?rbios de pelagem
(65,8%) e os dist?rbios de queratiniza??o (46,6%). Dos sinais cl?nico-gerais n?o cut?neos, destacaram-se
dist?rbios metab?licos (19,6%) e reprodutivos (19,2%). O diagn?stico de hipotireoidismo foi realizado
atrav?s de dosagens dos horm?nios tireoidianos e TSH (18%), pela bi?psia e histopatologia de pele
(35,3%) e pela associa??o entre estes m?todos (46,7%). Neste ?ltimo grupo de animais, a histopatologia
foi considerada como o m?todo de diagn?stico mais eficaz para o hipotireoidismo (97,6% / 98,2%). Com
rela??o ?s dosagens hormonais, a efic?cia para este diagn?stico foi menos expressiva: T4 Livre (72,7% /
75,8%) e T4 Total (77,8% / 73,9%). Dos animais com hipotireoidismo, 68,5% tinham 1 ou 2 doen?as
secund?rias ou associadas ? endocrinopatia, das quais destacam-se os processos imunomediados
(45,9%). Dos animais hipotireoideos, 157 foram submetidos ao tratamento, com resposta positiva em
93,6%. As f?meas (57,9%) foram mais acometidas. Animais com idades entre 1 a 8 anos (81,6%)
representaram a faixa et?ria mais freq?entemente afetadas. Dentre as 43 ra?as de c?es acometidas, foram
consideradas predispostas Chow Chow, Shar pei e Cocker Spaniel Ingl?s.
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