This thesis examines the effects of product composition, reactant temperature, reactant pressure, fuel-air equivalence ratio, diluent addition, and fuel composition on entropy generation in a constant internal energy/constant volume combustion process. Equilibrium product composition is shown to produce less combustion-generated entropy than frozen product composition. Using methane as the fuel, it is found that increasing reactant temperature by 100 K decreases entropy generation by 6 to 9 percent, while reactant pressure has little effect on entropy generation. Total entropy generation is increased with excess air and increased diluent addition. For the three fuels considered in this analysis (CH4, C2H5OH, C8H18), iso-octane uniformly exhibits the highest entropy generation, indicating the strong effect of fuel type and structure on combustiongenerated entropy.