In this thesis, high-voltage nitrile-based electrolytes for lithium ion batteries were investigated. The electrolytes were composed of nitrile, dinitrile, and vinylene carbonate (VC) as an additive. Scanning electron microscopy showed the change of surface morphology of electrodes. The chemical compositions of the solid electrolyte interface were characterized by high resolution X-ray photo electron spectroscopy (HR-XPS). We found that the optimal ratio of dinitrile to nitrile is 6 to 4 by volume in terms of electrochemical performances. 5wt% VC as the additive has the enhanced electrochemical performances. The oxidation potential of the nitrile-based electrolytes can reach to 5.7 V. The discharge capacity of the Li||LiFePO4 cell with the nitrile-based electrolyte is about 80 mAhg-1 at a charge/discharge rate of 5 C under 30 oC, and its discharge efficiency after 100 cycles still keeps 94.35%.

<p>Cilj ove doktorske disertacije je&nbsp; bila&nbsp; sinteza novih steroidnih&nbsp;16,17-seko-16,17a-dinitrila polazeći od&nbsp;dehidroepiandrosterona (1), odnosno&nbsp; estrona (14).&nbsp; U&nbsp;androstanskoj seriji&nbsp; su izvr&scaron;ene modifikacije&nbsp; 16,17-seko-16,17a-dinitrila&nbsp; 12&nbsp; u A i/ili B prstenu steroidnog jezgra, pri&nbsp;čemu novosintetizovana jedinjenja&nbsp; sadrže&nbsp; 4-en-3-on, 1,4-dien-3-on ili 1,4,6-trien-3-on sistem, kao i supstituente u&nbsp;položajima C-4, odnosno C-6&nbsp; (6-metilen, 6-keto i 6-oksimino).&nbsp; U&nbsp; radu&nbsp; je takođe&nbsp; proučavan&nbsp; uticaj odabranih&nbsp;novosintetizovanih jedinjenja na proliferaciju sedam ćelijskih&nbsp;linija humanih tumora, dok je kao kontrola služila jedna&nbsp;zdrava humana ćelijska linija.</p> / <p>Starting from dehydroepiandrosterone (1) or estrone (14)&nbsp;new steroidal 16,17-seco-16,17a-dinitriles&nbsp; were&nbsp;synthesized. Modification of 16,17-seco-16,17a-dinitrile&nbsp;12&nbsp; afforded&nbsp; androstane derivatives containing 4-en-3-on,&nbsp;1,4-dien-3-on or 1,4,6-trien-3-on system,&nbsp; with&nbsp; different&nbsp;substituents on position C-4 or C-6 (6-methylene, 6-keto i&nbsp;6-oximino).&nbsp; Antiproliferative activity&nbsp; of&nbsp; some&nbsp; newly&nbsp;synthesized&nbsp; compounds were examined&nbsp; against&nbsp; seven&nbsp;human tumor&nbsp; cell lines,&nbsp; while healthy cells&nbsp; served as&nbsp;control.</p>