Thesis (M.S.)--Rutgers University, 2009. / "Graduate Program in Chemical and Biochemical Engineering." Includes bibliographical references (p. 55-58).

Dissertation (Ph.D.)--University of Toledo, 2009. / Typescript. "Submitted as a partial fulfillment of the requirements for the Doctor of Philosophy degree in Biology." Bibliography: leaves 135-146.

Thesis (Ph. D.)--University of Washington, 2003. / Vita. Includes bibliographical references (leaves 82-95).

Thesis (Ph. D.)--University of Washington, 2003. / Vita. Includes bibliographical references (leaves 79-94).

Zugl.: Berlin, Freie Univ., Diss., 2008 / Includes bibliographic references.

Thesis (Ph. D.)--University of California, Riverside, 2009. / Includes abstract. Title from first page of PDF file (viewed March 8, 2010). Includes bibliographical references. Issued in print and online. Available via ProQuest Digital Dissertations.

Thesis (Ph. D.)--University of Kentucky, 2002. / Title from document title page. Document formatted into pages; contains vii, 158 p. : ill. Includes abstract. Includes bibliographical references (p. 128-155).

Non-covalent interactions are of great interest to chemists and biologists who study the molecular structure and function of biological systems, as well as those who seek to control, undo, or improve upon the efficiency of these systems with man-made chemical tools. The Iverson group has specifically applied noncovalent aromatic donor-acceptor interactions to biotic and abiotic aqueous systems through the use of the electron-rich 1,5-dialkoxynaphthalene (DAN) and electron-deficient 1,4,5,8-naphthalenetetracarboxylic diimide (NDI) moieties. Chapter 1 introduces and reviews the current state of self-assembly research, especially work conducted in aqueous media. Chapter 2 delineates the design and synthesis of a molecule that can self-assemble and form disulfide bonds, with the goal of creating higher-order structure. Chapter 3 comprises the design and synthesis of a series of pendant-NDI bisintercalators of DNA that are distinct from the backbone-incorporated intercalators previously employed in our laboratory. Chapter 4 contextualizes the term of art “pi-stacking,” reviewing the current state of knowledge of specific contributions to this effect and commenting on the putative uniqueness of the interaction. Theoretical and experimental work in the field is summarized. The work discussed in this dissertation serves to expand the scope of programmability of our DNA intercalators, to probe the higher-order assembly behavior of our donor-acceptor pair, and to clarify the term “pi-stacking,” lately overused, that imperfectly describes the interaction that gives both these systems their compelling binding properties. / text

ARID proteins are highly conserved among eukaryotes and are involved in chromatin remodeling, differentiation and development. The founding member of the ARID3 subfamily, Bright/ARID3A, is an activator of the immunoglobulin heavy chain locus. Bright has been shown to immortalize mouse embryonic fibroblasts and induce malignant transformation when co-expressed with oncogenic Ras. A genomic locus that encodes a gene paralogous to Bright has been identified as Brightlike/ARID3C. In addition to the highly conserved ARID and REKLES domains, Brightlike contains a conserved sumoylation motif. Brightlike orthologous genes have been identified in all vertebrate genomes examined. Its absence from EST databases suggested that it is a rare transcript, and accordingly, its expression in adult mice appears to be restricted to spleen, testes and thymus. Brightlike is also regulated by alternative pre-mRNA splicing, differential subcellular distribution, and post-translational modification by SUMO. The two isoforms of Brightlike appear to have differential expression in lymphocyte populations. Brightlike and Bright bind to the same DNA motif. Unexpectedly, Bright and Brightlike do not form heterocomplexes on DNA nor compete for binding, suggesting they have independent functions in vivo. Brightlike increases the proliferation potential of mouse embryonic fibroblasts and rescues cells from premature senescence, suggestive of a proto-oncogene. / text

abstract / Pharmacology and Pharmacy / Doctoral / Doctor of Philosophy