Bakgrunn: Misbruk av vanedannende legemidler er et viktig folkehelseproblem. Enkelte pasienter går fra lege til lege og driver såkalt legeshopping for å skaffe seg mest mulig av denne typen legemidler. Dette er et problem i forhold til å kunne begrense legemiddelmisbruket i befolkningen. Fastlegeordningen, som ble innført i Norge i 2001, er blant annet ment å skulle begrense mulighetene til legeshopping. Det er ikke tidligere gjort studier som kan kartlegge omfanget av legeshopping i en befolkning, verken i Norge eller andre land. FORMÅL: Kartlegge omfanget av legeshopping i befolkningen i Norge, og forsøke å klarlegge i hvilken grad bruk av flere leger kan skyldes shopping etter legemidler eller andre årsaker. MATERIALE OG METODE: Studere data fra det norske Reseptregisteret (NorPD) for kalenderåret 2004, som blant annet viser antallet leger benyttet, mengde utlevert av det aktuelle legemiddelet og samtidig mengde utlevert av benzodiazepiner og opioider for alle brukere av de vanedannende legemidlene diazepam, karisoprodol og kodein kombinasjoner sammenlignet med alle brukere av de ikke-vanedannende legemidlene esomeprazol, metformin og salbutamol. RESULTATER: De aller fleste pasienter bruker kun en eller to leger for å få utlevert samme legemiddel i løpet av ett kalenderår. Andelen som bruker tre eller flere leger er imidlertid mer enn dobbelt så høy for de vanedannende legemidlene som for de ikke-vanedannende, og for de som bruker fem eller flere leger, er andelen nesten ti ganger større. Med økende antall leger som er benyttet, er dessuten økningen i både utlevert mengde av legemidlet og samtidig mengde utlevert av benzodiazepiner og opioider langt mer uttalt for de vanedannende legemidlene enn for de ikke-vanedannende. KONKLUSJON: Det foregår etter innføringen av fastlegeordningen fortsatt en begrenset, men klar legeshopping blant pasienter som ønsker å få tak i mest mulig av vanedannende legemidler. Dette forhold må tas alvorlig av både de forskrivende legene og helsemyndighetene. / BACKGROUND: Abuse of prescription drugs is an important public health issue. Some patients go from one physician to another in so-called doctor-shopping (or physician-shopping) with the intention to have as much as possible of addictive drugs prescribed. This is a problem when trying to restrict prescription drug abuse in the population. The Regular General Practitioner (RGP) Scheme which was introduced in Norway in 2001 had among other things the intention to counteract doctor-shopping. So far there are no studies in Norway or other countries that have presented estimates of the proportions of patients that practice doctor-shopping. AIM: To explore the extent of doctor-shopping in the population in Norway and try to unveil if the use of several doctors is primarily a prescription drug shopping or if it has other reasons. MATERIAL AND METHODS: Data from The Norwegian Prescription Database (NorPD) for the year of 2004 was studied. The register includes information on the number of doctors used by individual patients and the amount of drug dispensed. There is also information about concomitant use of opioids and benzodiazepines. Users of the addictive drugs diazepam, carisoprodol and codeine combinations were compared to users of the non-addictive drugs esomeprazole, metformin and salbutamol. RESULTS: Most patients use only one or two doctors for prescription of the same drug over a period of one year. However the proportion of patients who uses three or more doctors for the addictive drugs is more than twice the comparable proportion of patients using the non-addictive drugs. For those who uses five or more doctors the proportion is nearly ten times larger. The amount of dispensed drug increases considerably more by increasing number of doctors used for users of the addictive drugs than for the users of the non-addictive drugs, as do the amount of concomitantly dispensed opioids and benzodiazepines. CONCLUSION: Also after the introduction of the Regular General Practitioner (RGP) Scheme in Norway doctor-shopping is still going on to a limited but significant extent by patients who appear to have the intention to get as much as possible of addictive drugs. This is a public health issue that has to be taken seriously by both prescribing doctors and health authorities. / <p>ISBN 978-91-85721-60-3</p>

La douleur chronique non-cancéreuse (DCNC) est un problème de santé qui touche environ une personne sur cinq au Canada. Elle est associée à une dégradation de la qualité de vie physique et mentale et occasionne des coûts économiques importants. Pour lutter contre la DCNC, les opioïdes ont été largement recommandés et prescrits malgré l’absence de preuves de leur efficacité à long terme, entraînant une augmentation des surdoses. Ces surdoses mais surtout celles causées par le fentanyl illicite ont fait naître une crise sanitaire, la crise des opioïdes. Pour juguler cette crise, des lignes directrices ont été émises pour encadrer de façon plus stricte la prescription d’opioïdes pour la DCNC. Cependant ces mesures peuvent constituer des barrières d’accès aux traitements pour les personnes vivant avec de la DCNC. Il est donc important de garantir un accès sécuritaire aux opioïdes à ceux qui en ont besoin pour fonctionner tout en limitant l’accès inapproprié qui alimente la crise des opioïdes. L’objectif de cette thèse était d’identifier les personnes susceptibles de bénéficier d’une utilisation efficace et sécuritaire des opioïdes à long terme et de mieux comprendre la douleur et les difficultés d’accès au traitement chez les personnes utilisatrices de drogues (PUD). Une première étude, visant à identifier les prédicteurs de l’efficacité des opioïdes à long terme, n’a pas permis de faire ressortir des caractéristiques des personnes susceptibles d’en bénéficier. Deux autres études ont permis d’étudier le nomadisme médical (doctor shopping), un indicateur d’utilisation problématique d’opioïdes, qui consiste à obtenir des ordonnances qui se chevauchent de plusieurs médecins et à les faire dispenser dans différentes pharmacies. Les résultats ont montré que cette pratique est rare chez les personnes vivant avec de la DCNC mais qu’elle peut être associée à la survenue de surdose. Les caractéristiques des personnes à risque de faire du nomadisme médical ont été identifiées permettant ainsi un meilleur suivi. Enfin, une dernière étude a montré que la DCNC est très fréquente chez les PUD et qu’une proportion importante de cette population a recours à des drogues illicites pour soulager leur douleur, courant ainsi le risque de faire une surdose. Ces études montrent la nécessité d’une médecine personnalisée tenant compte des caractéristiques et situations individuelles afin de prescrire le bon médicament à la bonne personne. En somme, ces résultats ont permis d’accroître les connaissances scientifiques sur l’utilisation des opioïdes pour la DCNC. / Chronic non-cancer pain (CNCP) is a health problem that affects about one in five people in Canada. CNCP is associated with a deterioration of physical and mental health-related quality of life and incurs significant economic costs. To better manage CNCP, opioids have been widely recommended and prescribed despite the lack of evidence on their long-term effectiveness, leading to an increase in opioid overdoses. These overdoses but mainly those caused by illicit fentanyl have led to the opioid crisis. To address this crisis, guidelines have been issued to tighten the prescribing of opioids for CNCP. However, these measures can exacerbate barriers of access to treatment for people living with CNCP. Therefore, it is important to ensure safe access to opioids for those who need this medication to improve function while reducing inappropriate access that contributes to the opioid crisis. The aim of this thesis was to identify the characteristics of patients who may benefit from effective and safe long-term opioid therapy and to better understand pain and treatment access difficulties among people who use drugs (PWUD). An initial study, which aimed at examining predictors of long-term opioid efficacy, failed to identify characteristics of those likely to benefit from opioid therapy. Two other studies investigated doctor shopping, an indicator of problematic opioid use, which consists of obtaining overlapping prescriptions from several doctors and pharmacies. The results showed that this practice is rare among people living with CNCP but may be associated with the occurrence of opioid overdose. The characteristics of people at high-risk to engage in opioid doctor shopping were identified, thus allowing better monitoring. Finally, a last study showed that CNCP is very frequent among PWUD and that a significant proportion of this population uses illicit drugs to relieve their pain, which can increase the risk of overdose. These studies show the need for personalized medicine considering individual characteristics and specific situations to prescribe the right drug to the right person. In summary, these results have increased the scientific knowledge about the long-term opioid use in CNCP.