Thesis (M.F.A.)--Rochester Institute of Technology, 2007. / Typescript.

Thesis PlanB (M.S.)--University of Wisconsin--Stout, 2006. / Includes bibliographical references.

Thesis (Ph. D.)--University of Texas at Austin, 2008. / Vita. Includes bibliographical references.

Thesis (Ph.D.)--Boston University

Made available in DSpace on 2014-06-11T19:25:37Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-02-22Bitstream added on 2014-06-13T20:14:23Z : No. of bitstreams: 1 souza_tfb_me_araca.pdf: 990469 bytes, checksum: 2edda3c74283bbc14ffbed941509caad (MD5) / Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) / Fundação para o Desenvolvimento da UNESP (FUNDUNESP) / O objetivo deste trabalho foi o de avaliar a cicatrização óssea de fraturas experimentais do radio de cães, tratadas ou não com o PRP autógeno, por meio de estudos radiográfico, densitométrico e histológico; bem como avaliar a expressão dos fatores de crescimento do PRP. Foram utilizados 21 cães inicialmente agrupados de acordo com o tempo de colheita de biopsia: aos sete dias (n=10) ou 60 dias (n=11) que foram alocados aleatoriamente em dois grupos experimentais: o grupo controle (G-controle, n=11) e o grupo PRP (G-PRP, n=10). Todos os animais foram submetidos à osteotomia e osteossíntese (fixador esquelético externo) do rádio direito, gerando-se um “gap” de 2,0mm, que foi preenchido ou não com PRP. Os estudos radiográficos e densitométricos foram realizados no pós-operatório imediato e até 60 dias de pós-operatório. As avaliações histológicas e imunoistoquímicas foram realizadas aos sete e 60 dias. Os dados encontrados foram tratados estatisticamente (p<0,05). Houve diferença significativa nas avaliações radiográficas e densitométricas entre os grupos. A avaliação histológica evidenciou uma cicatrização óssea mais avançada aos 60 dias no G-PRP e união óssea tardia no G-controle. Houve imunomarcação intensa do PDGF-B e TGF-β no G-PRP aos sete e 60 dias de pós-operatório. Conclui-se, que o PRP pode ser utilizado como terapia adjuvante, pois promoveu melhor cicatrização óssea em fraturas experimentais (“gap” de 2,0mm) do radio de cães tratadas com fixador esquelético externo. Ainda houve maior expressão do PDGF-B e TGF-β nos períodos, precoce e tardio, dos animais tratados com PRP / The present article aimed to assess bone healing of experimental radial fractures, treated or not with autologous PRP, by means of radiographic, densitometric and histological studies and evaluate the expression of growth factors in PRP. Were used 21 dogs initially grouped according to the time of biopsy collection: seven days (n = 10) or 60 days (n = 11) were randomly assigned to two groups: the control group (G-control, n = 11) and the PRP group (G-PRP, n = 10). All animals underwent osteotomy and fixation (external skeletal fixation) of the right radius, generating a gap of 2.0 mm, which was filled or not with PRP. Radiographic and densitometry studies were performed in the immediate postoperative period and to 60 days after the surgery. The histological and immunohistochemical evaluations were performed at seven and 60 days. The data were treated statistically (p <0.05). There were significant differences in densitometric and radiographic evaluations between the groups. Histological evaluation showed a more advanced bone healing at 60 days in G-PRP and bone union late in the G-control. There was intense expression of PDGF-B and TGF-β in G-PRP from seven to 60 days postoperatively. It is concluded that the PRP can be used as adjuvant therapy, because it provided better bone healing in experimental fractures (gap of 2.0 mm) radius of dogs treated with external skeletal fixation. Although there was a higher expression of PDGF-B and TGF-β in periods, early and late, the animals treated with PRP

Made available in DSpace on 2014-06-11T19:23:44Z (GMT). No. of bitstreams: 0 Previous issue date: 2004Bitstream added on 2014-06-13T18:19:54Z : No. of bitstreams: 1 brinholi_rb_me_botfmvz.pdf: 2584808 bytes, checksum: 9d6b793f686390f6b23ad45cf38aaf38 (MD5) / Universidade Estadual Paulista (UNESP) / Os valores da densidade mineral óssea (DMO) da extremidade distal do rádio-ulna de 95 cães de diferentes portes e idades foram determinados por meio da técnica de densitometria óptica em imagens radiográficas. Para a medida da DMO foi utilizado um programa computacional que analisou a densidade óptica das radiografias confeccionadas em projeção crânio-caudal da extremidade distal do rádio-ulna e de partes moles adjacentes, juntamente com uma escala de alumínio (penetrômetro), usada como referência densitométrica, permitindo a medida da DMO do rádio-ulna, que corresponde ao valor em milímetros de alumínio da escala. Os valores da média e os desvios padrões da densidade mineral óssea da extremidade distal do rádio-ulna da amostra foram: 2,38 ± 0,70 mmAl para cães entre 01 e 10 Kg, 3,55 ± 1,04 mmAl para cães entre 10,1 e 25 Kg, e 4,69 ± 0,90 mmAl para cães com mais de 25 Kg. Ocorreu forte correlação (p<0,001) entre a DMO e o peso dos animais estudados, sendo que a DMO não foi significativamente influenciada pelo sexo e nem pela idade dos animais. / The values of bone mineral density (BMD) of distal ext remity radius - ulna of 95 dogs of different weights and ages were determinated using the technique of optical densitometry in radiographic images. To measure BMD it was used a computer software that analyses the optical density of radiographic in craniocaudal view from the distal extremity radius - ulna and adjacent soft parts, with an aluminum scale (penetrometer), used as a densitometry reference, allowing the measurement of the radius - ulna BMD, that corresponds to the value in millimeters of the scale. The mean values and the standard deviation of bone mineral density of the extremity radius - ulna of the sample were: 2,38 ± 0,70 mmAl for dogs between 01 and 10Kg, 3,55 ± 1,04 mmAl for dogs between 10,1 and 25Kg, and 4,09 ± 0,90 mmAl for dogs over 25Kg. There was a strong correlation (p<0,001) between the BMD and the studied animals weight, although BMD was not significantly influenced by the animals sex or age.

Orientador: Júlio Carlos Canola / Banca: Paola Castro Moraes / Banca: Carlos Artur Lopes Leite / Resumo: Neste estudo foram radiografadas articulações coxofemorais de seis cães adultos, de duas raças, provenientes de dois Canis da Polícia Militar em três momentos, no período de um ano. Para predizer sobre a influência do exercício sobre a displasia coxofemoral, em estudo retrospectivo, correspondente a um período de oito anos, foram reavaliadas radiografias de 259 cães displásicos procurando estabelecer, entre outras variáveis, as diferentes modalidades de lesões radiográficas visibilizadas nesta afecção, considerando que estes animais, por informações pessoais de seus proprietários, não eram expostos rotineiramente a exercícios físicos. Na fase experimental, a raça Pastor Alemão foi a única acometida, a articulação esquerda se mostrou com maiores alterações e as lesões se mantiveram constantes nos três momentos. Na fase retrospectiva, os animais mais afetados eram das raças Rottweiler, Pastor Alemão e SRD e com mais de cinco anos de idade. O porcentual de machos e fêmeas afetados foi semelhante e o acometimento da displasia coxofemoral foi quase sempre bilateral e com grau de lesões simétrico. Pode-se concluir que o exercício não foi fator de progressão para cães com displasia coxofemoral. Se supervisionado, mesmo intenso, pode ser bastante benéfico para as articulações coxofemorais / Abstract: In this study, the hip joints of six adult dogs of two breeds, from two kennels belonging to the military police were radiographed three times in one year. To predict the influence of exercise on hip dysplasia, 259 radiographs of dysplastic dogs were reviewed in a retrospective study corresponding to a period of eight years trying to establish, among other variables, all types of radiographic lesions found in this condition since these animals, according to personal information of the owners, were not routinely exposed to physical exercise. In the experimental phase of this study, the German Shepherd Dog was the only affected breed, the left joint showed more alterations and lesions remained constant in the three evaluations. In the retrospective phase, the most affected dogs were Rottweiler, German Shepherd Dog and crossbreeds and the most affected were older than five years of age. The percentage of affected males and females was similar and the involvement of hip dysplasia was mainly bilateral and the degree of injury was mostly symmetrical. It can be concluded that the exercise was not a progress factor for dogs with hip dysplasia. If supervised, even when intense, exercise can be quite beneficial for hip joints / Mestre

The objective of this study was to non-invasively document the changes in echocardiographic variables of left ventricular size and function during acute normovolaemic anaemia. This model was developed as a pilot study with the purpose of providing baseline information to investigate the pathophysiology, and more specifically the effect on the heart, of canine babesiosis-induced anaemia. The study group comprised of 11 mature healthy Beagle dogs that weighed between 9 and 15 kg. Severe normovolaemic anaemia was induced over a 3-4 day period by serial bleeding while maintaining normovolaemia by autotransfusing plasma and infusing crystalloids. The dogs were then allowed to recover. Pre-anaemic [mean haematocrit (Hct) 46.7%, standard deviation (SD) 2.4%)] echocardiographic variables of left ventricular size and performance were statistically compared to those in the severely [mean Hct 15.3 %, SD 1.1%], moderately [mean Hct 24.7%, SD 1.5%] and mildly [mean Hct 33.5%, SD 2.5%] anaemic states, and between the anaemic states. The following variables were measured: left atrial size; left ventricular fractional shortening, ejection fraction, end-systolic and end-diastolic ventricular volumes and their derivatives [stroke volume, stroke index, cardiac output, cardiac index]; systolic time intervals [left ventricular ejection time (LVET), pre-ejection period (PEP), velocity of circumferential shortening, LVET/PEP and LVET index (LVETI)]; and heart rate. With the exception of end diastolic volume, left atrial size, LVET/PEP and LVETI, there was a statistically significant (p < 0.05) change in all variables in the severely anaemic state versus the pre-anaemic and the mild and moderate anaemic states. In accordance with previous invasive models, this study demonstrates the hyperdynamic state of the left ventricle that develops in response to experimentally induced acute canine normovolaemic anaemia in the conscious dog, and shows promise as a non-invasive technique of evaluating the cardiac changes in dogs suffering from canine babesiosis. / Dissertation (MMedVet(Diagnostic Imaging))--University of Pretoria, 2005. / Companion Animal Clinical Studies / unrestricted

It is known that the prevalence of CSs in some breeds approaches 100%. In addition, this study identified previous CSs, fewer than eight and more than 11 puppies per litter in Boerboel bitches as obstetric risk factors (resulting in emergency CSs and stillbirths). It also showed that a trial of labour after caesarean section was associated with considerable obstetric risks. In such high-risk pregnancies, using the signs of parturition to time elective CSs in the bitch is problematic, as by then there may already be foetal distress or demise. Also, the signs of parturition may present at an inconvenient time of the day, when staff shortages may impede professional service. This study aimed at solving these problems by investigating various means of predicting the day and time of onset of parturition (cervical dilatation) in the bitch. This study showed that a chemiluminescent immunoassay (Immulite® 1000 LKPW1) is a reliable replacement for a discontinued radio immune assay to measure PC in serum or plasma. It proved that the first day of cytological dioestrus (D0) is the most precise peri-oestrous predictor of the day of cervical dilatation. This study showed that the variation in the foetal biparietal diameter is too large to accurately predict readiness for CS and that the preparturient PC may be used to predict the time of cervical dilatation, thereby allowing timeous planned CSs in bitches where D0 is unknown. The use of medetomidine hydrochloride as premedicant combined with propofol as induction agent and sevoflurane as maintenance, is safe and is associated with good maternal and puppy survival rates at delivery, 2 h and 7 d after CSs. Performing elective CSs upon the first appearance of any degree of cervical dilatation proved successful. For bitches in this study with high-risk pregnancies, we proved that it is safe to perform fixed date preparturient CSs on D57 if the cervix has not dilated by then. This study showed that bitches have haematocrits at the time of cervical dilatation that are at the lower end of the normal reference ranges for non-pregnant dogs and that the decline in haematocrit associated with CS is similar for parturient (open cervix) and preparturient (closed cervix) CSs. As incidental findings, this study discovered two puppies sharing one placenta in each of two litters. The one case of placenta sharing proved to be monozygotic twins whilst the other case proved to be a case of dizygotic monochorionic canine foetuses with blood chimaerism and suspected freemartinism. This study provides the veterinary obstetrician with a protocol that can be used to safely perform elective CSs in a large proportion of the obstetric population at a convenient time of the day but more research is required with larger numbers to establish whether this practice is routinely safe and safe in all breeds. / Die voorkoms van keisersnitte bereik 100% in sommige rasse. Hierdie studie het getoon dat ʼn vorige keisersnit, kleiner werpsels as agt en groter werpsels as 11 in die Boerboel, verloskundige risikofaktore is. Dit het ook getoon dat ʼn poging tot spontane kraam nadat ʼn teef voorheen ʼn keisersnit ondergaan het, geassosieer is met 'n aansienlike risiko van noodkeisersnitte en doodgebore hondjies. Om in sulke hoë risiko dragtighede te wag vir tekens van kraam voordat ʼn elektiewe keisersnit uitgevoer word is riskant, omdat fetale nood of dood reeds kon intree. Die tekens van kraam verskyn dikwels op ʼn ongeleë tyd van die dag, wanneer ʼn personeeltekort ʼn professionele diens belemmer. Hierdie studie was daarop gemik om hierdie probleme op te los deur verskeie metodes te ondersoek om die dag en tyd van aanvang van servikale ontsluiting in die teef te voorspel. Verskeie bevindings spruit uit die studie: ʼn Chemiluminessensie immunotoets (Immulite® 1000 LKPW1) is ʼn betroubare plaasvervanger vir ʼn gestaakte radioimmunotoets. Die eerste dag van sitologiese diestrus (D0) is die mees presiese en praktiese peri-estrus voorspeller van die dag van servikale ontsluiting. Die bipariëtale deursnit van honde fetusse tydens laat dragtigheid varieer soveel binne rasse en binne werpsels dat dit ongeskik is vir die akkurate en betroubare voorspelling van gereedheid vir keisersneë. Die voorgeboortelike progesteroon konsentrasie in die bloedplasma of serum dien as ʼn voorspeller van kraam in tewe waarvoor D0 nie bekend is nie. Die binneaarse toediening van 7 mg/kg medetomidine hidrochloried as premedikasie, gekombineer met 1–2 mg/kg propofol as induksiemiddel en 2% sevoflurane in suurstof vir die onderhoud van narkose vir keisersnit in tewe is veilig en lewer hoë oorlewings peile in tewe en kleintjies by geboorte, 2 ure en 7 dae na keisersnit. Keisersnitte wat uitgevoer word sodra die eerste tekens van servikale ontsluiting waargeneem word, is suksesvol. Hierdie studie het getoon dat vir tewe met hoë risiko swangerskappe, dit veilig is om preparturiente keisersnitte uit te voer in tewe met n geslote serviks, sewe en vyftig dae (D57) na D0 vir tewe met werpsels > 1 as die serviks teen daardie tyd nog nie ontsluit het nie. Tewe se hematokrit aan die begin van kraam stem ooreen met die laer normale waardes van vir nie-dragtige honde en dat vermindering in hematokrit geassosieer met parturiente keisersnitte (oop serviks) soortgelyk is aan bloedverlies geassosieer met preparturiente (geslote serviks) keisersnitte. Toevallige bevindings was dat twee fetusse uit elk van twee werpsels ʼn plasenta gedeel het. In een geval was die fetusse monosigotiese tweelinge en in die ander geval was hulle monochorionies en disigoties, met moontlike freemartinisme. Hierdie studie stel die veterinêre verloskundige in staat om elektiewe preparturiënte keisersnitte op ʼn geleë tyd van die dag uit te voer in ʼn hoë persentasie van die obstetriese populasie maar verdere navorsing met groter getalle word benodig om vas te stel of dit roetine gewys veilig is en veilig is in alle rasse. / Thesis (PhD)--University of Pretoria, 2017. / Production Animal Studies / PhD / Unrestricted

During the academic year 1960-1961, the Department of Experimental Surgery, of the University of Cape Town, engaged in a series of experiments concerning the production of profound hypothermia in dogs. Hypothermia was induced by blood-stream cooling, via a heat exchanger incorporated in an extra-corporeal pump-oxygenator system (ef Appendix A). Progress was such that by midyear postoperative survival of experimental animals was assured. At this juncture, it was suggested that, as a member of the Renal-Metabolic Group of the Department of Medicine, I co-operate wit the surgeons, in a study of renal function during profound hypothermia in the dog. This thesis details our progress and results.