Salivary duct carcinoma (SDC) is an uncommon neoplasm showing extensive local invasion and metastasis. Histologically it exhibits ductal differentiation without myoepithelial participation and resembles intraductal and invasive ductal carcinoma of the breast. This study investigates the incidence of intraductal disease within invasive SDC and characterizes the expression of CK19, COX-2, MMP-2, 9 and 11 in intraductal and invasive SDC. 21 conventional SDC, 8 SDC arising as carcinoma ex-pleomorphic adenoma (CaExPA), 2 pure low-grade intraductal SDC, 1 pure high-grade intraductal SDC and 1 intraductal SDC with de-differentiation were studied. The presence of intraductal tumor in SDC is relatively common (52.4%) but is not a prominent component. SDC tumor cells were strongly positive for CK19 and COX-2. MMP-2 and 9 expression showed no significant pattern. MMP-11 was expressed by fibroblasts surrounding invasive tumor and was significantly associated with lymph node positivity (p=0.02).

Although the issue of uncertainties in cost model parameters has been recognized as an important aspect of life-cycle cost analysis, it is often ignored or not well treated in cost estimating. A simulation approach employing kernel estimation techniques and their asymptotic properties in the development of the probability distribution functions (PDFs) of cost estimates is proposed. This eliminates the guess work inherent in current simulation based cost estimating procedures, reduces the amount of data sampled and makes it easier to specify the accuracy desired in the estimated distribution. Building energy costs can be reduced considerably if air duct systems are designed for the least life-cycle cost. The IPS-Method, a simple approach to HVAC air duct design is suggested. The Diameter and Enhanced Friction Charts are also developed. These are charts that implicitly incorporate the LCC and are better than the existing Friction Chart for the selection of duct sizes. Through illustrative examples, the ease and effectiveness of these are demonstrated. For more complex designs, a Segregated Genetic Algorithm (SGA) is recommend. A sample problem with variable time-of-day operating conditions and utility rates is used to illustrate its capabilities. The results are compared to those obtained using weighted average flow rates and utility rates to show the life-cycle cost savings possible by using this approach. Although life-cycle cost savings may be only between 0.4% and 8.3% for some simple designs, much larger savings may occur with more complex designs and operating constraints. The SGA is combined with probabilistic cost estimating to optimize HVAC air duct systems with uncertainties in the model parameters. The designs based on the SGA method tended to be less sensitive to typical variations in the component physical parameters and, therefore, are expected to result in lower balancing and operating costs.

The convective mass transfer coefficient is determined for evaporation in a horizontal rectangular duct, which forms the test section of the transient moisture transfer (TMT) facility. In the test facility, a short pan is situated in the lower panel of the duct where a hydrodynamically fully developed laminar or turbulent airflow passes over the surface of the water. The measured convective mass transfer coefficients have uncertainties that are typically less than ±10% and are presented for Reynolds numbers (ReD) between 560 and 8,100, Rayleigh numbers (RaD) between 6,100 and 82,500, inverse Graetz numbers (Gz) between 0.003 and 0.037, and operating conditions factors (H*) between -3.6 and -1.4. The measured convective mass transfer coefficients are found to increase as ReD, RaD, Gz and H* increase and these effects are included in the Sherwood number (ShD) correlations presented in this thesis, which summarize the experimental data.<p> An analogy between heat and mass transfer is developed to determine the convective heat transfer coefficients from the experimentally determined ShD correlations. The convective heat transfer coefficient is found to be a function of ShD and the ratio between heat and moisture transfer potentials (S*) between the surface of the water and the airflow in the experiment. The analogy is used in the development of a new method that converts a pure heat transfer NuD (i.e., heat transfer with no mass transfer) and a pure mass transfer ShD (i.e., mass transfer with no heat transfer) into NuD and ShD that are for simultaneous heat and mass transfer. The method is used to convert a pure heat transfer NuD from the literature into the NuD and ShD numbers measured in this thesis. The results of the new method agree within experimental uncertainty bounds, while the results of the traditional method do not, indicating that the new method is more applicable than the traditional analogy between heat and mass transfer during simultaneous heat and mass transfer.<p>A numerical model is developed that simulates convective heat and mass transfer for a vapor permeable Tyvek® membrane placed between an airflow and liquid water. The boundary conditions imposed on the surfaces of the membrane within the model are typical of the conditions that are present within the TMT facility. The convective heat and mass transfer coefficients measured in this thesis are applied in the model to determine the heat and moisture transfer through the membrane. The numerical results show that the membrane responds very quickly to a step change in temperature and relative humidity of the air stream. Since the transients occur over a short period of time (less than 1 minute), it is feasible to use a steady-state model to determine the heat and mass transfer rates through the material for HVAC applications.<p>The TMT facility is also used to measure the heat and moisture transfer through a vapor permeable Tyvek® membrane. The membrane is in contact with a water surface on its underside and air is passed over its top surface with convective boundary conditions. The experimental data are used to verify the numerically determined moisture transfer rate through the Tyvek® membrane. The numerical model is able to determine the mass transfer rates for a range of testing conditions within ±26% of the experimental data. The differences between the experiment and the model could be due to a slightly different mass transfer coefficient for flow over Tyvek® than for flow over a free water surface.

Noise between 25-500 Hz is a common problem in Heating, Ventilating, and Air Conditioning (HVAC) systems. The American Society of Heating, Refrigerating, and Air-Conditioning Engineers (ASHRAE) Handbook lists values of end reflection loss (ERL), a frequency dependent parameter describing energy reflected back up a duct at a termination impedance, to help engineers design and account for noise. The ASHRAE Handbook does not account for common termination variations and only lists ERL values using octave bands down to 63 Hz. This thesis experimentally determined the ERL of a variety of rectangular duct configurations and termination conditions between 25-500 Hz. This research also compared experimental ERL results with analytic predictions and ASHRAE Handbook values. Seven duct sizes were tested, from 6X6 to 18X54 inches. Duct termination baffle hardness was varied between acoustically hard (plywood) and soft (ceiling tiles) for the 6X6, 6X10, and 6X18 ducts. Five duct termination distances above the termination baffle were tested, between flush and 1D for the 6X10 and 6X18 ducts and between flush and 5D for the 6X6 duct, where D equals the duct s effective diameter. Diffusers and flex duct configurations were installed at the end of the rigid duct to test their effect on ERL on the 6X6, 6X10, and 6X18 ducts. ERL was determined using an adaptation of the ASTM E1050 Standard, an application of the two-microphone impedance tube method. Experimental results closely conformed to analytic predictions and are an improvement over ASHRAE Handbook ERL values. The results indicate that baffle hardness has a negligible impact on ERL, which contradicts the ASHRAE assumption that diffusers that terminate in a suspended lay-in acoustic ceiling can be treated as terminating in free space. Termination distance above the baffle has a negligible impact on ERL at distances less than six inches for the 6X6 duct. Termination distances above the baffle greater than six inches exhibit limited free space ERL behavior for the 6X6 duct. The use of flex duct greatly reduces low frequency ERL and this is not accounted for by the ASHRAE Handbook. The impact from flex duct usage also negates any influence from downstream termination variations.

No description available.

<p>Increased national and international travel over the lastdecades has caused an increase in the global number ofpassengers using different means of transportation. Greateffort is being directed to improving the noisy environment inthe residential community. This is to face the growing strictnoise requirements which are implemented by international noiseregulatory authorities, governments, and local airports. Thereis also a strong competition between different manufacturers tomake their products quieter. The propulsion system in anaircraft is the major source of noise during relevant flightconditions. The engine noise in a vehicle dominates the totalradiated noise at low speeds especially inside cities. Manyrecent studies on noise reduction involve the use of perforatedplates in the air and gas flow ducting connected to the engine.This thesis deals with the modelling of perforates as anabsorbent.</p><p>There are many difficulties in using liners in theseapplications. The most important is that there is no largesurface area to which the linings may be applied. Equally, theenvironment in which linings have to survive is hostile.Therefore, liners have to be carefully tailored in order toachieve the most efficient attenuation. The full-scalesimulation testing, which is usually necessary to define thenoise attenuation produced by a liner installation, is bothtime-consuming and expensive. Therefore, a need for accuratemodels is a must. This thesis fills some gaps in the impedancemodelling of perforated liners. It also concentrates on thosecomplicated situations of sound propagation in ducts that weresolved earlier using Finite Element Methods. Alternateanalytical solutions to these problems are developed here,which gives more physical insight into the results.</p><p>The key design parameter of perforates is the acousticimpedance. The impedance is what determines their efficiency toabsorb sound waves. A semi empirical impedance model wasdeveloped to be capable of accurately predicting the linerimpedance as a function of its physical properties and thesurrounding conditions. It was compared to all previous modelsin the literature. Nothing in the literature has been reportedon the effect of temperature on the perforate impedance,therefore a complete study was performed. A new inverseanalytical impedance measurement technique was proposed. It isbased on educing the impedance value based on the measurementof the attenuation across a lined duct section. Twoapplications were further considered: The effect of hard stripsin lined ducts on there attenuation properties; and themodelling of perforations in a complicated automotive mufflersystem.</p><p><b>Keywords:</b>Perforates–Liners–Acousticimpedance–Hot stream liners–Hard splices–Mufflers–Lined ducts–Collocation–Flowduct.</p>

The presence of inflammation in the progression of fatty liver disease induced by fasting was determined in mink. Tumour necrosis factor alpha (TNF-?), and monocyte chemoattractant protein 1 (MCP-1) liver mRNA levels were quantified by real-time PCR. Mink fasted for 5 and 7 days had significantly higher levels of TNF-? and MCP-1 liver mRNA, compared to mink fasted for 0, 1, and 3 days. Mink fasted for 7 days, but re-fed for 28 days had the lowest mRNA levels of both TNF-?, and MCP-1 demonstrating the liver’s ability to restore homeostasis post-fasting. TNF-? mRNA levels were correlated with MCP-1 liver mRNA and liver fat percent. To confirm the physical presence of inflammation, slides stained with haematoxylin and eosin were analyzed for bile ducts resulting in no significant differences. Results indicate that elevated MCP-1 and TNF-? expression are associated with fasting induced fatty liver in mink.

The existence of hydrodynamically developed, laminar Viscoelastic Secondary Flows (VSFs) of non-Newtonian fluids in straight ducts of non-circular cross-section was proposed in the 1950's. VSFs have since been observed sporadically, and only once with a velocimetric technique. Using axial and transverse full flow-field velocity-position raster maps made with Rheological Nuclear Magnetic Resonance (Rheo-NMR), Newtonian and non-Newtonian fluid flows were quantified in Hagen-Poiseuille and Power Law contexts, over more than two orders of magnitude of flow rate, in ducts of circle, square, triangle, and pentagon cross-section. VSF was reliably and repeatedly observed to occur at between one part in 130 and one part in 600 of the primary axial flow velocity. Velocity measurements ranged from <10 µm/s to approximately 30 cm/s, suggesting a velocity dynamic range >3E4 without optimization. To obtain VSF flow direction information, a novel flow directional phantom was developed and characterized. Aqueous solutions of Polyethylene Oxide (PEO), Viscarin GP-109NF, Viscarin GP-209NF (V209), Hyaluronan (HA) in a Phosphate-Buffered Saline-like solvent, and an aqueous Polyethylene Glycol/PEO-based Boger fluid were investigated. Axial data was corroborated with related data gathered by an independent method. Basic simulations corroborated the VSF observations. Duct hydraulic diameters (>= 1.6 mm) approached the micro-channel regime. VSF detections in HA --- synovial fluid's principal component --- and V209 were novel, as were observations of some artifacts which were subsequently characterized and corrected. The detection of VSF in HA represents the first experimental evidence suggesting that its second normal stress (N_2) is comparable to that of better-characterized fluids. In the first application of a new VSF-based method, a particular Boger fluid's constant viscosity and, in the square duct, its lack of VSF were used with established criteria to suggest that the fluid's N_2 approached zero. The development of a rudimentary, but versatile and inexpensive home-built velocimetric spectrometer is detailed, as are several new components. An exhaustive VSF literature review is included. The remarkable transverse velocimetric ability of Rheo-NMR in both optically opaque and transparent system is highlighted, suggesting that perhaps the technique might represent, in both micro-channels and conventional ducts, the gold-standard in flow velocimetry.

Combined Cycle power plants have recently become a serious alternative for standard coal- and oil-fired power plants because of their high thermal efficiency, environmentally friendly operation, and short time to construct. The combined cycle plant is an integration of the gas turbine and the steam turbine, combining many of the advantages of both thermodynamic cycles using a single fuel. By recovering the heat energy in the gas turbine exhaust and using it to generate steam, the combined cycle leverages the conversion of the fuel energy at a very high efficiency. The heat recovery steam generator forms the backbone of combined cycle plants, providing the link between the gas turbine and the steam turbine. The design of HRSG has historically largely been completed using thermodynamic principles related to the steam path, without much regard to the gas-side of the system. An effort has been made using resources at both UK and Vogt Power International to use computational fluid dynamics (CFD) analysis of the gas-side flow path of the HRSG as an integral tool in the design process. This thesis focuses on how CFD analysis can be used to assess the impact of the gas-side flow on the HRSG performance and identify design modifications to improve the performance. An effort is also made to explore the software capabilities to make the simulation an efficient and accurate.

The effect of rotation on flow in a gas turbine blade cooling duct model is investigated experimentally. The present work consists of velocity measurements at different locations in a test section with a 180° bend with ribs on one wall. Three geometric rib parameters are considered; rib-rib spacing, rib orientation angle and rib blockage ratio. PIV is used for flow visualization and analysis. Along with the clean duct measurements, ribs with blockage ratios, b/h, of 0.25 and 0.125 were considered. The b/h = 0.25 cases have been comprehensively analyzed while the b/h = 0.125 cases have been studied at the post-bend region of the duct only. Reynolds number considered is in the range of approximately 5000-40,000 and the rotation speed is varied for a rotation number from 0 to 7. It is observed that rotation has a significant effect on secondary flows within the rotating duct. For blockage ratio, b/h = 0.25, at a constant Re and Ro, the RMS of fluctuations of velocity do not show large spatial variations with ribs or rib orientations. At higher Re, the value decreases in comparison to the low Re cases. The kinetic energy of fluctuations increases due to the presence of ribs, indicating better heat transfer for the ribbed duct, but do not show large variations with rib orientation angle. The fluctuations and kinetic energy show maximum values at the post-bend regions of the duct. The velocity fields and PDFs show a possible cause for e°cient heat transfer for the 45° rib arrangement as compared with the 90° rib cases. At high Ro, the absolute value of circulation has a large increase at the post-bend and thereafter there is a gradual decay at the exit for all cases. The ribs with blockage ratio of b/h = 0.125 showed no marked changes in circulation with changes in rib orientation angle, thus implying that the rib blockage plays a role in the generation of secondary flows, particularly in conjunction with rotation.