The effects of the fenretinide and genistein as single or combined drugs on ovarian cancer proliferation and viability were investigated. Hypothesis: Co-treatment with genistein will enable a lower dose of fenretinide to be effective in inhibiting the proliferation and survival of ovarian cancer cells. Methods: Low and high doses of genistein and fenretinide were tested on A2780s and A2780cp cells using trypan blue viable cell count, MTS assay. Results and conclusions: Unlike low doses of fenretinide, genistein had anti-proliferative effects on both cell lines. There were no additive or synergistic effects of the two compounds. Higher dose treatments induced anti-proliferative effects and apoptotic cell death in both A2780s and A2780cp cells, with a greater sensitivity of A2780s cells to both test compounds. Overall Conclusion: Genistein and higher doses of fenretinide similarly impair cell cycle progression and induce apoptosis. The anti-proliferative effects of genistein can be affected by co-treatment with fenretinide

F'ritz: von Unruh, who lives at Oranieuhof in Diez an der Lahn, was born in 1885. He wrote the first two parts of his trilogy Ein Geschlecht during the literary movement in Germany which is known as Expressionismus". The yet, unpublished third part was not finished until 1958. It was in this trilogy that he developed his ideas of a new world. The upheaval and destruction of World War I shattered the complacency of life and traditions which had so long been ingrained in Europe. This traumatic experience resulted in a new examination of life, its meaning and sense. The stark reality in which Germany found herself after the war and the contradictory abundance of material, intellectual and spiritual striving in social and economic worlds appeared as a prelude for a new order in the world Gestalt. It was during this time that Unruh began work on his trilogy which was to incorporate his idea of a new world. Two facts are especially important in the development of his ideas. First, he himself was of noble birth. The traditions of unquestionable service and loyalty to church and state were a part of him. The sense of duty which was deeply ingrained in him experienced, however, a fundamental change. This change became the nucleus for his trilogy. Secondly, his experiences as an officer in World War I served as an impetus in the development of his Weltanschauung. His newly found idea of a new world may be seen as an evolving process which first finds expression in his war poem Vor der Entscheidung and is brought to realization in the trilogy. 'The central theme of this thesis is an interpretation of these works which will show the development of his ideas. They lead us from rebellion to chaos and to a new cosmos.

ABSTRACT This research report examines the opera Der Silbersee: Ein Wintermärchen (The Silver Lake: a Winter’s Tale), 1932, by Kurt Weill and Georg Kaiser, as an example of what Weill defined as ‘new opera’, in his essay ‘Der Neue Oper’.1 It will discuss reasons for the work’s rarity in its relative neglect as well as its significance as an example of what Kim Kowalke has called a synthesis of Weill’s ‘mature style’. Thus it will also be demonstrated that the work, even though rarely performed and often overlooked, is an important bridge between the works of Weill’s ‘German period’ and his later works in the United States. It will be established that the work is of musicological significance as well as of interest and relevance to present-day theatregoers. The research argues that the work, though written in Germany during the 1930s as a form of operatic protest, is worthy of being seen as a timeless and universal piece, deserving of more attention. This investigation will be accomplished through an analysis of Weill’s own writings found in his many essays, translated and collected by Kim Kowalke in his book Kurt Weill in Europe, through an examination of the historical and socio-political perspective of the work, as well as in a musical analysis.

Zugl.: Tübingen, Universiẗat, Diss., 2006.

Zugl.: Darmstadt, Techn. Universiẗat, Diss.

Akademisk avhandling--Humanistiska fakulteten--Uppsala, 1980. / Bibliogr. p. 220-228.

Zugl.: Rostock, Univ., Diss., 2009

Frankfurt (Main), Univ., Diss., 2000. / Erscheinungsjahr an der Haupttitelstelle: 1999

Essen, Universiẗat, Diss., 2003--Duisburg.

Techn. University, Diss., 2004--Berlin.