To identify the risk factors being associated with aetiology of amyotrophic lateral sclerosis (ALS), a series of systematic reviews based on existing observational epidemiological studies identified through searching of bibliographic databases were conducted. Associations between ALS and a number of genetic and environmental risk factors were examined using meta-analysis. Specifically we found that previous exposure to lead, pesticides, solvents, experience of trauma and electric shock were associated with relative increased risks of developing ALS of 86% [odds ratio (OR) =1.86, 95% CI: 1.39-2.48], 57% (OR=1.57,95% CI: 1.19-2.08), 47% (OR=1.47, 95%CI: 1.13-1.80), 64% (OR=1.64; 95%CI: 1.36-1.98), and 2.27% (OR=3.27, 95%CI:1.87-5.73) respectively, compared to their corresponding controls. The presence of intermediate CAG repeat expansion in the ATXN2 gene was associated with a 4.4 -fold increase in the risk of ALS (OR=4.44, 95%CI: 2.91-6.76). However, the attributable risk associated with each identified risk factor was estimated to be less than 5% of all ALS cases. These results confirm that ALS is a rare multifactorial degenerative condition of motor-neurons.

The diploma thesis focuses on the issue of fires of small photovoltaic power plants located on the roofs of buildings. When a photovoltaic power plant is being fired, the photovoltaic system is a very dangerous part of the power generation technology. In this part of the power plant, it is very problematic that the switching off of the electric dc current and the fire-fighters can cause electric shock. In the research part there is description and photodocumentation of the visited photovoltaic power plants, where the tour was carried out with an emphasis on the possible fire of the object. An important part of this chapter is the case studies of PPS fires and electric shocks. In addition, an overview of several fire interventions already carried out on the photovoltaic power plant located on the roof of the building. Finally, the author identified weaknesses for effective and safe intervention and processed the firefighting documentation for the PPSs visited. The discussion contains an indication of the identified shortcomings in the methodological sheets of the Combat Order of Fire Protection Units. The author outlines the possible risks for intervening firefighters at the PPSs visited and compares the elimination of these risks in the processing of firefighting documentation. Also mentions photovoltaic power plants in floodplains and points to potential hazards when flooding the PPS. Finally, a proposal is made to modify the Combat Order of Fire Protection Units and measures to ensure greater security of firefighters during fires of photovoltaic power plants.

To identify the risk factors being associated with aetiology of amyotrophic lateral sclerosis (ALS), a series of systematic reviews based on existing observational epidemiological studies identified through searching of bibliographic databases were conducted. Associations between ALS and a number of genetic and environmental risk factors were examined using meta-analysis. Specifically we found that previous exposure to lead, pesticides, solvents, experience of trauma and electric shock were associated with relative increased risks of developing ALS of 86% [odds ratio (OR) =1.86, 95% CI: 1.39-2.48], 57% (OR=1.57,95% CI: 1.19-2.08), 47% (OR=1.47, 95%CI: 1.13-1.80), 64% (OR=1.64; 95%CI: 1.36-1.98), and 2.27% (OR=3.27, 95%CI:1.87-5.73) respectively, compared to their corresponding controls. The presence of intermediate CAG repeat expansion in the ATXN2 gene was associated with a 4.4 -fold increase in the risk of ALS (OR=4.44, 95%CI: 2.91-6.76). However, the attributable risk associated with each identified risk factor was estimated to be less than 5% of all ALS cases. These results confirm that ALS is a rare multifactorial degenerative condition of motor-neurons.