The current study sought to investigate whether physiological responses, such as the electrodermographic response (EDG) and/or the frontalis muscle electrical potential (EMG) could be developed as a source of control over verbal responses. Discrimination training procedures using points exchangeable for money were employed to condition verbal responses occasioned by minute interoceptive events with 2 adult human subjects. Specific verbal responses were reinforced in the presence of changes in EDG with Sl and EDG and EMG with S2. Stimulus control over differentiated verbal responses was demonstrated with both subjects. The results suggest that minute interoceptive events can enter into controlling relations with verbal responses and that this control is partially a function of the size or range of physiological responses as well as conditioning history.