Since a few decades ago, world seems flat because of globalization, however, cultural diversity also creates challenges and problems for individuals and organizations. Cultural intelligence (CQ), defined as an individual¡¦s capability to function and manage effectively in culturally diverse settings (Earley & Ang, 2003). CQ can explain why some individuals are more effective than others in culturally diverse situations; therefore, it¡¦s important for everyone. Until now, relatively researches mainly focuses on the influence of CQ. To know antecedents of CQ, this study developing and testing a model including external factor and internal factor, and posits differential relationships among the four CQ dimensions (metacognitive, cognitive, motivational and behavioural), employment cross-cultural exposure, and Big Five personality (Conscientiousness, Agreeableness, Emotional stability, Extraversion, and Openness to experience). The results demonstrate employment cross-cultural exposure predicted all of the four CQ dimensions; extraversion and openness to experience predicted metacognitive, motivational and behavioural CQ; and employment cross-cultural exposure has stronger effect on behavioural CQ through moderating effect of conscientiousness.