In this paper, we present the design and evaluation of CQ-Buddy, a peer-to-peer (p2p) continuous query (CQ) processing system that is distributed, and highly-scalable. CQ-Buddy exploits the differences in capabilities (processing and memory) of peers and load-balances the tasks across powerful and weak peers. Our main contributions are as follows: First, CQ-Buddy introduces the notion of pervasive continuous queries to tackle the frequent disconnected problems common in a peer-to-peer environment. Second, CQ-Buddy allows for inter-sharing and intra-sharing in the processing of continuous queries amongst peers. Third, CQ-Buddy peers perform query-centric load balancing for overloaded data source providers by acting as proxies. We have conducted extensive studies to evaluate CQ-Buddy’s performance. Our results show that CQ-Buddy is highly scalable, and is able to process continuous queries in an effective and efficient manner. / Singapore-MIT Alliance (SMA)

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Due to the trend of economic globalization, the new challenge that companies are facing when pursuing growth is the need of internationalization talented persons. To maintain the best competitiveness of organization, the key point lies in looking for the most talented employee. How to choose talented persons multi-nationally and how to train internationalization talented persons is one of the keys for the existence of modern enterprises. The ¡§Expatriate¡¨ so called in this study means the one sent by the company to work in the country or area outside homeland. They are likely to be employees with the nationality of their parent company or third country. However, they must be the appropriate and trustworthy middlemen chosen by their parent company. How do enterprises choose such expatriates? What kind of characteristics should successful expatriates have in competence for their tasks? Herein, this study starts from personality and targets on expatriates to probe into the relationship among personality, cultural intelligence and entrepreneurship. The raw data for further research has 2 parts: pre-survey and formal survey. While Convenience Sampling Method was taken, the researcher picked particular interviewees, delivered the questionnaires, and invited for more interviewees to join. Since the objects are geographically wide-spreaded among the world, the survey forms were distributed through the Internet. 260 copies were sent, and 230 recovered. 88% recovery rate has been obtained. Through the statistics methodology, the variables were defined and calculated. The internal relationships among the variables were explored through tools of descriptive statistics, Pearson analysis, SEM model and Variance analysis. The conclusions are as following: 1. There is a positive and significant correlation between the personality and Cultural Intelligence. Stronger ¡§Extraversion¡¨ personality has highest CQ. Comes the ¡§Openness to Experience,¡¨ then the ¡§Agreeableness¡¨. 2. It is obviously positive and significant correlation between personality and entrepreneurship. People with strong ¡§Openness to Experience¡¨ attitude bear stronger willness and capability on entrepreneurship. Follows the ¡§Extraversion,¡¨ then the ¡§Agreeableness¡¨. 3. CQ is obviously positive and significant correlated to entrepreneurship. People with higher CQ bears better capability on entrepreneurship. 4. The study also discovered that the personality has obvious positive influence on entrepreneurship, directly and indirectly. That is, the personality of dispatched personnel would enhance individual entrepreneurship, via the interaction of higher CQ. 5. Personal attributes (e.g. gender, marital status, age, nationality, education level, reason for dispatch, company scale and industry nature) shall play a significant variant role as personality, CQ and entrepreneurship level.

Das subjektive Wohlbefinden (SWB) spiegelt die Gesamtbeurteilung des Lebens (globales SWB) und die Höhen und Tiefen des täglichen Lebens (erfahrungsbezogenes SWB) wider. Eine Fülle von Belegen deutet darauf hin, dass gesundheitliche Herausforderungen die langfristige Aufrechterhaltung des globalen SWB älterer Erwachsener sowie ihre Emotionsregulation vor Ort gefährden (Barger et al., 2009). Gleichzeitig behauptet die Lebensspannenpsychologie, dass sich das SWB als Ergebnis gesundheitlicher Anfälligkeiten entfaltet, die in ein System von Kontextebenen eingebettet sind, das vom Individuum bis zur Dyade reicht (Baltes & Smith, 2004). Allerdings haben nur wenige Studien mehr als eine Facette der Gesundheit oder des SWB untersucht, noch haben sie typischerweise individuelle Unterschiede (Persönlichkeit) oder sozial-kontextuelle Antezedenzien (z. B. die Gesundheit von signifikanten anderen Personen) untersucht. Um diese Lücken zu schließen, untersucht diese Dissertation: (i) die langfristigen Verläufe mehrerer Facetten des globalen SWB im Alter und ihre Vorhersage durch den objektiven Gesundheitszustand; sowie die kurzfristige Variabilität der Facetten des erfahrungsbezogenen SWB älterer Erwachsener als Ergebnis (ii) anlassbezogener Abweichungen des Gesundheitszustands und (iii) anlassbezogener Abweichungen des Gesundheitszustands des Ehepartners. In jeder Studie wird zusätzlich die Rolle des Neurotizismus untersucht. Zu diesem Zweck verwenden diese Studien fünf unabhängige Datensätze älterer Erwachsener, die objektive, leistungsbezogene und subjektive Maße der Gesundheit und des SWB über drei zunehmend feinere Zeitskalen erhoben haben. Die Ergebnisse dieser Dissertation zeigen, dass es älteren Erwachsenen gelingt, gesundheitliche Herausforderungen zu überwinden, um das SWB über kurze und lange Zeiträume aufrechtzuerhalten. Dabei werden die Kontexte hervorgehoben, in denen dieser Erfolg versagt (angesichts der gesundheitlichen Gefährdung des Ehepartners). / Subjective well-being (SWB) reflects our overall appraisals of life (global SWB) and the ups and downs of everyday living (experiential SWB). Lifespan developmental theory considers the maintenance of SWB in the face of age-related loss an indicator of successful aging (Baltes & Baltes, 1990). However, such loss limits the resources necessary to maintain SWB across old age, with a wealth of evidence that health challenges threaten the long-term maintenance of older adults’ global SWB as well as their in-situ regulation of emotions (Barger et al., 2009). At the same time, lifespan psychology maintains that SWB unfolds as a result of health vulnerabilities embedded into a system of contextual layers from the individual to the dyad (Baltes & Smith, 2004). However, few studies have examined more than one facet of health or SWB, nor have they typically examined individual differences (personality) or social-contextual antecedents (e.g., health of significant others). To address these gaps, this dissertation examines: (i) the long-term trajectories of multiple facets of global SWB across old age and their prediction by objective health; as well as the short-term variability in facets of older adults’ experiential SWB as a result of (ii) occasion-specific deviations in health; and (iii) occasion-specific deviations in one’s spouses’ health. Each study additionally examines the role of neuroticism. To do so, these studies utilize five independent datasets of older adults that sampled objective, performance-based, and subjective measures of health and SWB across three increasingly finer timescales. The findings of this dissertation showcase older adults’ success at overcoming health challenges to maintain SWB across short and long-time scales, and in doing so, highlights the contexts where such success falls short (in the face of spousal health vulnerabilities).

Since a few decades ago, world seems flat because of globalization, however, cultural diversity also creates challenges and problems for individuals and organizations. Cultural intelligence (CQ), defined as an individual¡¦s capability to function and manage effectively in culturally diverse settings (Earley & Ang, 2003). CQ can explain why some individuals are more effective than others in culturally diverse situations; therefore, it¡¦s important for everyone. Until now, relatively researches mainly focuses on the influence of CQ. To know antecedents of CQ, this study developing and testing a model including external factor and internal factor, and posits differential relationships among the four CQ dimensions (metacognitive, cognitive, motivational and behavioural), employment cross-cultural exposure, and Big Five personality (Conscientiousness, Agreeableness, Emotional stability, Extraversion, and Openness to experience). The results demonstrate employment cross-cultural exposure predicted all of the four CQ dimensions; extraversion and openness to experience predicted metacognitive, motivational and behavioural CQ; and employment cross-cultural exposure has stronger effect on behavioural CQ through moderating effect of conscientiousness.

BACKGROUND: Less than two decades into the 21st century, U.S. medical schools are experiencing substantial curricular reform affecting multiple aspects of teaching and learning. The pace of change is rapid when compared to that of the previous century. Little changed in medical education for 100 years after Abraham Flexner’s 1910 recommendations from his evaluation of North American medical schools. Using a case-study approach to examine a single medical school, this dissertation study explores pre-clerkship faculty perspectives of select curricular changes over a ten-year span at Boston University School of Medicine (BUSM). These changes include the adoption of educational technologies and student-centered pedagogical approaches, as well as curricular content integration designed for foundational science courses. PURPOSE: This study seeks to understand and document faculty experiences with change, factors influencing change, effective and challenging aspects of change, and recommendations for successful future changes. It also explores faculty change adoption tendencies and change leadership styles for those who led groups through a newly integrated curriculum. METHODS: This is a mixed-methods study using qualitative and quantitative inquiry in three phases of data collection with two subject sets. In the first phase, qualitative data was collected from interviews with a subset of 12 subjects to inform creation of a researcher-designed survey, which was used in the second phase collecting responses from a larger pool of 55 subjects. The third phase collected quantitative data from an externally-validated instrument, Change Intelligence (CQ) (Trautlein, 2013), which assessed change leadership styles of the subset of 12 subjects who experienced all changes studied. RESULTS: BUSM faculty members are motivated towards continuous improvement of the curriculum to foster students’ success. Faculty are challenged by compressed time to plan and implement change and when change is mandated without opportunity for pre-decision input. BUSM faculty adopt changes at higher rates than the normal curve defined in Diffusion of Innovations (Rogers, 2003). The subset of 12 subjects assessed for change leadership styles focus on people and process when leading change. CONCLUSION: Medical education change studies on the faculty perspective are limited. This study provides insight and recommendations for future study and successful change.

In this paper we discuss iterative algorithms for solving the split feasibility problem (SFP). We study the CQ algorithm from two approaches: one is an optimization approach and the other is a fixed point approach. We prove its convergence first as the gradient-projection algorithm and secondly as a fixed point algorithm. We also study a relaxed CQ algorithm in the case where the sets C and Q are level sets of convex functions. In such case we present a convergence theorem and provide a different and much simpler proof compared with that of Yang [7].

Individuelle Unterschiede in der kognitiven Entwicklung von Kindern korrelieren mit ihrem sozioökonomischen Status (engl. socioeconomic status, SES). Allerdings hat die bisherige Forschung längsschnittliche Dynamiken meist ignoriert. Des Weiteren sind die Mechanismen, die zu SES–bedingten Diskrepanzen in der kognitiven Entwicklung führen, weitgehend unbekannt. Gemäß einer Hypothese ist es die Dysregulation der Sekretion des Stresshormons Cortisol die SES Unterschiede vermittelt, da niedriger SES robust mit höherem chronischen Stress assoziiert. Die vorliegende Dissertation weist im Längsschnitt nach, dass Veränderungen im Familieneinkommen die kognitive Entwicklung von armen Kindern im späteren Kindesalter vorhersagen (Studie I). Bemerkenswerterweise wirkt kindliche Kognition auch auf Veränderungen im elterlichen Einkommen, was auf bisher vernachlässigte bidirektionale Familiendynamiken hinweist. Zudem liefert die Dissertation querschnittliche empirische Evidenz für die Hypothese, dass ein stressbezogener Mechanismus in SES–bedingten Unterschieden kognitiver Entwicklung involviert ist. Höherer Stress und ein geringeres Einkommen waren beide mit Anzeichen des Hypocortisolismus in Kindern charakterisiert (Studie II und III). Außerdem gab es Hinweise, dass kognitive Kontrolle vor den Effekten von Stress schützen könnte (Studie II). Schließlich zeigt die Dissertation erstmalig, dass hyporeaktive Cortisolprofile in Reaktion auf akuten Stress in ärmeren Kindern mit deren niedrigerer Gedächtnisleistung assoziiert ist (Studie III). Beachtenswert ist, dass Ergebnisse dieser Dissertation nicht auf Umwelt oder genetisch vermittelte Kausalität schließen lassen. In zukünftigen Interventionsstudien sollte weiter untersucht werden, ob Interventionen die Einkommensgewinne stärken, Stress reduzieren oder die Reaktion von Kindern auf akuten Stress verbessern, kognitive Unterschiede im Zusammenhang mit SES verringern. / Individual differences in cognitive development in childhood vary along gradients of socioeconomic status (SES). Yet, research has largely ignored longitudinal dynamics, despite evidence that SES, especially income, also changes over time. Furthermore, fairly little is known about the mechanisms by which SES explains cognitive disparities. Lower SES environments are marked by high chronic stress exposure, which has led to the hypothesis that dysregulation of the stress response system resulting in altered cortisol secretion mediates disparities in cognition. This dissertation provides longitudinal evidence for the notion that family income gains and losses predict poor children’s cognitive development throughout later childhood (Paper I). Remarkably, children’s cognition also predicts their parents’ earning ability, indicating previously neglected bidirectional family dynamics. Moreover, this dissertation provides cross–sectional evidence for a stress mechanism involved in SES disparities of cognitive functioning. Both higher stress and lower income are associated with patterns of hypocortisolism in middle childhood (Paper II & III). Further, cognitive control skills may buffer against the embedding of stress exposure in diurnal cortisol secretion (Paper II). Lastly, cortisol hyporeactivity to stress found in low–income children is uniquely associated with their lower memory performance. Notably, this dissertation does not warrant environmentally– or genetically–mediated assumptions of causality. Future intervention studies should continue to explore whether facilitating family income gains, reducing stress exposure, normalizing cortisol secretion, or improving children’s stress coping by training cognitive control alleviates SES–related disparities in cognition.

Malaria is currently a huge treat worldwide, as far as infections are concerned, and is responsible for thousands of deaths per annum. The dilemma associated with the development of anti–malarial drug resistance over the past few decades should be addressed as a matter of urgency. Novel drug delivery systems should be developed in order to employ new and existing anti–malarial drugs in the treatment and management of malaria. The aim of these delivery systems should include an improvement in the efficacy, specificity, acceptability and therapeutic index of anti–malarial drugs. Previous studies have suggested that liposomes have the ability to encapsulate, protect and to promote the sustained release of anti–malarial drugs. Two liposome formulations, namely liposomes and chloroquine entrapped in liposomes, were formulated during this thesis and evaluated by conducting a stability study and an in vitro study with the main focus on cell viability. The stability study consisted of a series of stability tests regarding the stability of nine liposome and nine chloroquine entrapped in liposome formulations over a period of twelve weeks. The in vitro study included three assays such as a reactive oxygen species assay, a lipid peroxidation assay and a hemolysis assay. The aims of these studies included the manufacturing of liposomes, the incorporation of chloroquine into liposomes, the determination of the stability of the formulations as well as the evaluation of the possible in vitro toxicity of liposomes. Results obtained from these studies revealed that liposomes remained more stable over the stability study period in comparison to chloroquine entrapped in liposomes. The entrapment of chloroquine within liposomes was possible, although the initial entrapment efficiency (%) of 14.55 % was much too low. The production of reactive oxygen species occurred to a small extent in the red blood cells and the infected red blood cells. Equal amounts of reactive oxygen species (%) was observed within both the red blood cells and the infected red blood cells with a maximum value of 23.27 % in the presence of the chloroquine entrapped in liposomes at varying concentrations. Red blood cells experienced the highest degree of lipid peroxidation (%) in the presence of chloroquine, at varying concentrations, entrapped in liposomes. The maximum amount of lipid peroxidation (%) was 79.61 %. No significant degree of hemolysis (%) was observed in the red blood cells neither in the presence of the liposomes nor in the presence of the chloroquine entrapped in liposomes at varying concentrations. It can be concluded that liposomes are a more stable formulation and have less toxic effects on red blood cells and infected red blood cells in comparison to the chloroquine entrapped in liposome formulations. Future studies should investigate the possibility of a more stable and less toxic chloroquine entrapped in liposome formulation. / Thesis (M.Sc. (Pharmaceutics))--North-West University, Potchefstroom Campus, 2011.

Malaria is currently a huge treat worldwide, as far as infections are concerned, and is responsible for thousands of deaths per annum. The dilemma associated with the development of anti–malarial drug resistance over the past few decades should be addressed as a matter of urgency. Novel drug delivery systems should be developed in order to employ new and existing anti–malarial drugs in the treatment and management of malaria. The aim of these delivery systems should include an improvement in the efficacy, specificity, acceptability and therapeutic index of anti–malarial drugs. Previous studies have suggested that liposomes have the ability to encapsulate, protect and to promote the sustained release of anti–malarial drugs. Two liposome formulations, namely liposomes and chloroquine entrapped in liposomes, were formulated during this thesis and evaluated by conducting a stability study and an in vitro study with the main focus on cell viability. The stability study consisted of a series of stability tests regarding the stability of nine liposome and nine chloroquine entrapped in liposome formulations over a period of twelve weeks. The in vitro study included three assays such as a reactive oxygen species assay, a lipid peroxidation assay and a hemolysis assay. The aims of these studies included the manufacturing of liposomes, the incorporation of chloroquine into liposomes, the determination of the stability of the formulations as well as the evaluation of the possible in vitro toxicity of liposomes. Results obtained from these studies revealed that liposomes remained more stable over the stability study period in comparison to chloroquine entrapped in liposomes. The entrapment of chloroquine within liposomes was possible, although the initial entrapment efficiency (%) of 14.55 % was much too low. The production of reactive oxygen species occurred to a small extent in the red blood cells and the infected red blood cells. Equal amounts of reactive oxygen species (%) was observed within both the red blood cells and the infected red blood cells with a maximum value of 23.27 % in the presence of the chloroquine entrapped in liposomes at varying concentrations. Red blood cells experienced the highest degree of lipid peroxidation (%) in the presence of chloroquine, at varying concentrations, entrapped in liposomes. The maximum amount of lipid peroxidation (%) was 79.61 %. No significant degree of hemolysis (%) was observed in the red blood cells neither in the presence of the liposomes nor in the presence of the chloroquine entrapped in liposomes at varying concentrations. It can be concluded that liposomes are a more stable formulation and have less toxic effects on red blood cells and infected red blood cells in comparison to the chloroquine entrapped in liposome formulations. Future studies should investigate the possibility of a more stable and less toxic chloroquine entrapped in liposome formulation. / Thesis (M.Sc. (Pharmaceutics))--North-West University, Potchefstroom Campus, 2011.