Global ETD Search

21	Expression and localization of human endothelin-converting enzyme-1 isoforms in symptomatic atherosclerotic disease and saphenous vein. Jackson, C.D., Barnes, K., Homer-Vanniasinkam, Shervanthi, Turner, A.J. January 2006 (has links) No / Endothelln-converting enzyme (ECE-1) is a critical enzyme in the production of the potent vasoconstrictor peptide endothelin (ET-1). It has previously been shown that the levels of both ET-1 and ECE-1 are raised in atherosclerosis, but the possible relevance of the isoforms of ECE-1 in these changes has not yet been investigated. The aim of this study was to examine the expression of the ECE-1a and ECE-1c isoforms in human atherosclerotic pathologies. Immunohistochemical analysis was carried out on sections from atherosclerotic and non-atherosclerotic vascular tissue using a combination of ECE-1 isoform-specific antibodies, anti-¿-actin antibodies to identify smooth muscle cells (SMC) and anti-CD68 antibodies to identify macrophages. ECE-1 isoform expression was also examined in cultured SMC and in macrophages isolated from human blood. Results indicated differences in isoform expression in atherosclerotic lesions, with distinct patterns of staining for ECE-1 a and ECE-1 c. ECE-1 c immunoreactivity was seen in macrophages, and also correlated with actin staining. ECE-1a was also localized to macrophages and SMC. Results of this study suggest that these local changes influence the expression patterns of the ECE-1 isoforms within individual cell types. Correlation of these isoform expression patterns with the stage of atherosclerosis could provide novel indicators of disease progression. Vasculature Atherosclerosis Endothelins
22	Studies toward the total synthesis of biologically active agents I: yanucamide a and apratoxin a from marinecyanobacteria, II: nonpeptide endothelin receptor antagonist SB-209670 Xu, Zhengshuang., 許正雙. January 2003 (has links) published_or_final_version / Chemistry / Doctoral / Doctor of Philosophy Biological products - Synthesis Cyanobacteria. Metabolites. Endothelins - Receptors. Endothelins - Antagonists.
23	Effects of aging and gender on vasoreactivity of coronary arterioles LeBlanc, Amanda Jo. January 2008 (has links) Thesis (Ph. D.)--West Virginia University, 2008. / Title from document title page. Document formatted into pages; contains xi, 87 p. : ill. Vita. Includes abstract. Includes bibliographical references (p. 71-79).
24	Investigations into the role of endothelial endothelin-1 on transient focal cerebral ischemia Leung, Wai-chung, 梁偉聰 January 2007 (has links) published_or_final_version / abstract / Anatomy / Doctoral / Doctor of Philosophy Endothelins. Cerebral ischemia. Reperfusion injury.
25	Endothelium-dependent contractions in rodent aortae Tang, Hoi-ching, Eva., 鄧凱澄. January 2007 (has links) published_or_final_version / abstract / Pharmacology / Doctoral / Doctor of Philosophy Endothelins. Arteries - Physiology. Rodents - Physiology.
26	Mechanisms of exercise-induced asthma Makker, Himender Kuman January 1994 (has links) No description available. 610
27	The influence of chronic hypoxia on the responses to endothelin of the pulmonary circulation of rats / Das, Rapti. January 2001 (has links) Thesis (Ph. D.)--University of Hong Kong, 2001. / Includes bibliographical references.
28	Generation of transgenic and knockout constructs to study the role of endothelin-1 expression on the development of craniofacial and cardiac structures / Chiu, Wun, Kelvin. January 2002 (has links) Thesis (M. Phil.)--University of Hong Kong, 2002. / Includes bibliographical references (leaves 101-116).
29	Potentiating effects of platelet activating factor on endothelin-1 induced rat arota vasoconstriction 管漢偉, Koon, Hon-wai, Michael. January 1998 (has links) published_or_final_version / Pharmacology / Master / Master of Philosophy Platelet activating factor. Endothelins. Aorta.
30	The functional role of endothelin-1 in astrocytes by making use of endothelin-1 knockout mice 何仲賢, Ho, Chung-yin, Maggie. January 2000 (has links) published_or_final_version / Molecular Biology / Master / Master of Philosophy Endothelins - Receptors. Astrocytes. Mice - Physiology.

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