Spelling suggestions: "subject:"endothelial""
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Origins and Development of the Embryonic Vascular System in XenopusMyers, Candace Tamara January 2013 (has links)
Each step of vascular development needs to be carefully regulated; endothelial precursors must be specified, these cells then proliferate and coalesce to form vascular cords, and finally they lumenate, undergo angiogenic branching and remodeling, and recruit smooth muscle cells to establish a mature vessel. An aberration at any of these steps during embryonic development is incompatible with life, and vascular pathologies in the adult are associated with numerous diseases including stroke, arteriosclerosis, diabetic retinopathies and cancer progression. My work has aimed to understand how endothelial precursors are specified, and more precisely the cell-signaling pathways and transcriptional networks that guide their fate. This work leads us to conclude the following: (1) blood island precursor cells in the Xenopus embryo can give rise to either blood or endothelial cells, and it is BMP-mediated activation of the erythroid transcriptional program that regulates cell fate, (2) endothelial specification requires the Ets transcription factor Etv2. Persistence of Etv2 expression in blood/endothelial cell precursors allows these cells to develop into endothelium, and overexpression of Etv2 in any of the three germ layers causes activation of every endothelial marker examined. Along the way we have characterized a number of small-molecule inhibitors that should be useful to the Xenopus community and applicable to other model systems.
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Studies of endothelial progenitor cells and kinase inhibition in pulmonary arterial hypertensionToshner, Mark January 2011 (has links)
No description available.
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Characterization and regulation of Vascular Endothelial GrowthFactor (VEGF) receptors expression in the testis胡慶雲, Wu, Hing-wan. January 1999 (has links)
published_or_final_version / Zoology / Master / Master of Philosophy
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Identification and characterization of vascular endothelial growth factor (VEGF) in rat testis溫慧莊, Wan, Wai-chong. January 1998 (has links)
published_or_final_version / Zoology / Master / Master of Philosophy
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Adherence of sickle erythrocytes to vascular endothelium : therapeutic screening and the pathophysiology of pain crisisVassy, W. Matthew 08 1900 (has links)
No description available.
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Exposure of endothelial cells to shear stress stimulates protein tryosine phosphorylationJiang, Liying 05 1900 (has links)
No description available.
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The effects of fluid shear stress on the activity of protein kinase C, phosphatidylinositol 3-kinase and Rho in aortic endothelial cellsScott, Robert Orlando 05 1900 (has links)
No description available.
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Purification, stabilization, and crystallization attempts of a mutant form of endothelial nitric oxide synthasePresnell, Steven Ray 12 1900 (has links)
No description available.
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Morphological effects of spatial and temporal gradients of shear in a faithful human right coronary artery cell culture modelLentzakis, Helen. January 2007 (has links)
Dysfunction of the vascular endothelium can initiate atherosclerosis. Mechanical forces, particularly wall shear stress (WSS) are believed to cause endothelial dysfunction. Present in vitro cell culture models are often simplified and thus, ignore the wall shear stress spatial gradients inherent in complex geometries. The aim of this project was to study endothelial cell response in an anatomically correct right coronary artery model (RCA) under more physiologically realistic flow conditions. / Human Abdominal Aortic Endothelial Cells (HAAECs) were seeded in the lumen of a pre-treated faithful RCA and a straight tubular model. The cells were subjected to steady or non-reversing oscillatory flow (Re=196, alpha=1.82) at a mean physiological flow rate of 20 dynes/cm2 for 8, 12 and 24 hours of flow. The results show that under all flow conditions, the cells became progressively more elongated and aligned. Moreover, differences in endothelial morphology in the inner (myocardial) and outer (pericardial) walls were seen in the inlet region. The morphologic adaptation to steady and oscillatory flow was similar. The results suggest that spatial, not temporal gradients in shear in the inlet region are responsible for the differential endothelial cell response.
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A mathematical model of the dynamics of cytosolic free calcium in cultured vascular endothelial cells responding to shear stressWiesner, Theodore F. 08 1900 (has links)
No description available.
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