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Avaliação dos níveis séricos de IL-1b em pacientes com episódio atual de depressão, mania ou episódio mistos / Serum IL-1b levels in patients with current depression, mania and mixed episodesMota, Rosana Ramos Silveira da 12 July 2012 (has links)
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Previous issue date: 2012-07-12 / Conselho Nacional de Desenvolvimento Científico e Tecnológico / Objective: The purpose of this study was to clarify the effect of imune response in diferente mood episodes.
Methods: This report is part of a cross-sectional population-based study including 1560 individuals 18 to 35 year-old living in the urban area of Pelotas, RS (Brazil). We randomly selected 241 subjects from the population-based study. The diagnostic of current depression, mania or mixed episode was made using the Mini International Neuropsychiatric Interview 5.0 (MINI). Serum levels of IL-1b were measured using a commercial available immunoassay kit.
Results: In the present work we found 110 (45.6%) patients with no current mood episode, 15 (6.2%) patients in maniac episodes, 91 (37.8%) patients with current depression and 25 (10.4%) patients in a mixed states. Socio-demographic variables like ethnicity and years in school were not significantly different between the groups. Regarding the cytokine measurements, patients in maniac and depressive episodes had similar levels of IL-1b (8.85 and 8.90 pg/mL, respectively) when compared to the group with no mood episodes (10.24 pg/mL). However, patients in mixed states had an increase (13.19 pg/mL) in IL-1b levels (P=0.09) when compared to the other groups. Discussion: These results suggest that mixed mood episodes are associated with higher levels of IL-1b. This pro-inflammatory state might underlie the symptom severity and the poor outcome observed in these patients / Nos últimos anos as doenças psiquiátricas foram as doenças que mais aumentaram na população mundial (Andlin-Sobocki et al., 2005). Estima-se que os transtornos de humor serão o grupo de doenças com maior custo absoluto nos próximos anos, conjuntamente com as patologias demenciais (Andlin-Sobocki et al., 2005). Apesar dos recentes progressos alcançados, as bases etiológicas dos transtornos de humor permanecem pouco elucidadas e a terapia não tem sido totalmente eficaz, com apenas 60% dos pacientes sendo responsivos aos fármacos existentes no mercado (Gareri et al., 2000). Além disso, o diagnóstico dos transtornos de humor é feito basicamente pela observação clínica do paciente, sendo muitas vezes falho e ineficaz. Desta maneira, a identificação de marcadores biológicos preditivos ou com valor diagnóstico para estas doenças pode representar um importante avanço no diagnóstico e tratamento dos transtornos de humor
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