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Surface changes to human erythrocytes on infection by Plasmodium falciparum malariaGardner, Jason Paul January 1994 (has links)
Of the four Plasmodium species which cause malaria in humans, P. falciparum is responsible for the majority of the morbidity and mortality associated with this disease. The surface expression of parasite-derived proteins in the middle of the asexual cycle coincides with two important modifications of the host erythrocyte. First, a protective immune response is directed against a family of variant antigens, known as P. falciparum Erythrocyte Membrane Protein-1 (PfEMPl). Second, ligands are detected at the surface which mediate the specific cytoadherence of infected erythrocytes to vascular endothelium, such that infected cells are sequestered away from the peripheral circulation in deep vascular beds. The potentially fatal syndrome known as cerebral malaria can ensue when infected cells sequester at high density in the brain. Indirect studies have shown that the antigenic and adhesive phenotypes at the surface are linked to the expression of PfEMPl. However, there is a paucity of biochemical data which relate to PfEMPl, and this problem is addressed in this thesis. This study has confirmed, at the biochemical level, inferences from serology that clonal antigenic variation occurred rapidly. Variation produced a number of novel antigenic and adhesive phenotypes which were associated with unique forms of PfEMPl. Further insights into the mechanism of sequestration were possible because of the finding that single infected erythrocytes had the capacity to bind to at least three putative endothelial cell receptors; CD36, Intercellular Adhesion Molecule-1 (ICAM1), and Thrombospondin (TSP). It was demonstrated for the first time that PfEMPl was responsible for cytoadherence to CD36 and ICAM1, but was probably not involved in adhesion to TSP. Extensive analysis with sequence-specific proteases proved that adhesive interactions with each receptor were separable properties of the surface, and facilitated the proposal of a domain model for PfEMPl. Detailed analysis of the antigenic and adhesive phenotypes of a series of clonally-derived parasites demonstrated that infected cells expressing all variant antigenic types could adhere to CD36 whereas adhesion to ICAM1 was seen in a restricted subset. This may be clinically relevant if, as current data suggests, adhesion of infected cells to ICAM1 is important in the development of cerebral malaria. Identification of all ICAM1 binding phenotypes could lead to the design of novel therapeutic strategies for this life-threatening condition.
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Chicken histone H5 mRNA and its genes /Scott, Andrew Charles. January 1975 (has links) (PDF)
Thesis (Ph.D.) -- University of Adelaide, Dept. of Biochemistry, 1976? / Typescript (photocopy).
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Effects of light exposure on the release of oxygen from hemoglobin in a red blood cell suspensionToler, Tanikka Danielle, January 1900 (has links)
Thesis (M.S.)--Virginia Commonwealth University, 2008. / Prepared for: Dept. of Physiology and Biophysics. Title from title-page of electronic thesis. Bibliography: leaves 55-58.
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Erythrocyte biology and its impact on Plasmodium vivax invasionScheetz, Emily. January 2008 (has links)
Thesis (M.S.)--Case Western Reserve University, 2008. / [School of Medicine] Department of Pathology. Includes bibliographical references.
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The effects of smoking on blood cells, and the association between smoking and nutrient intake among pregnant women residing in northern West VirginiaKing, Rebecca, January 2000 (has links)
Thesis (M.S.)--West Virginia University, 2000. / Title from document title page. Document formatted into pages; contains v, 33 p. Vita. Includes abstract. Includes bibliographical references (p. 30-32).
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Genetic studies of human serum and erythrocyte polymorphisms: glucose-6-phosphate dehydrogenase, haptoglobin, hemoglobin, transferrin, lactic dehydrogenase, and catalase,Nance, Walter E. January 1968 (has links)
Thesis (Ph. D.)--University of Wisconsin--Madison, 1968. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.
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The thiourea carrier in human erythrocytesRozenbaum, Beny Leon 01 January 1975 (has links)
The main purpose of this work is to determine the characteristics of the thiourea carrier in human erythrocytes taking into consideration the two parameters of transfer (half-saturation constant and maximum transport rate) and the energy of dissociation of the carrier complex. In the president experiment, the problem has been approached by observing the exit of thiourea, from cells previously equilibrated with thiourea, into a saline medium containing different concentrations of thiourea. The most important advantages of this method are the rapidity of the exit process and the fact that it can be easily measured.
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Composition of avian, porcine, and bovine erythrocytes and avian liver plasma membranes in vitro incorporation of labeled sugar in erythrocytes.Gillis, Gregory H. January 1978 (has links)
No description available.
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Isolation, purification and immunochemical characterization of an Rh₀ (D) active lipoidal material from human erythrocytes /Traul, Karl A. January 1969 (has links)
No description available.
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Studies of the morphology and survival characterstics of erythrocytes from mice and rats with plasmodium berghei infection /Mohan, Ram January 1971 (has links)
No description available.
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