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Efeitos iniciais da ovariectomia e do tratamento com estrógeno e isoflavonas da soja, isolados e associados, na reparação óssea alveolar e no útero de ratasSilveira, Vanessa Ávila Sarmento [UNESP] 10 July 2007 (has links) (PDF)
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silveira_vas_dr_sjc.pdf: 653051 bytes, checksum: 288edba1011b8bcc5a34ac57d1a5bbfb (MD5) / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) / Due to the adverse effects of estrogen, new therapies have been proposed, such as soy isoflavones. However, their effects on bone repair and uterus epithelium remain unclear. The aim of this work was to study the acute effects of ovariectomy and treatment with estrogen and soy isoflavones, isolated or in association, on rat bone repair and uterus epithelium. 120 rats were used; 96 ovariectomized and 24 Sham-operated (SHAM). The ovariectomized rats were dibided into 4 groups, receiving orally: 1 mg/kg/day of 17 'beta'-estradiol valerate(OVZ-E); 15mg/kg/day of isoflavones (OVZ-I); associated treatments (OVZ-A); and vehile (OVZ). SHAM rats received vehicle. Treatment began on the ovariectomy day. The lower first molar was removed on both sides 15 days after ovariectomy. The rats received the treatment until sacrificed, which occurred at seven, 21 and 45 days after dental extraction. The uterus was submitted to histological analyses and the mandible to histological, histomorphometric, backscattered electron microscopy (BSE) and immunohistochemistry analyses. Concerning bone repair, no difference was observed in trabecular volume between the OVZ and SHAM groups for each period. Histological analysis and BSE revealed changes in bone microarchitecture after 45 days. Verification showed that the SHAM group presented a higher mean osteoid volume at seven days compared to the OVZ and OVZ-E groups and that the OVZ-A group showed the highest mean for this period. The number of mast cells tended to be higher in the OVZ group at 45 days. Strong expression of TGF-'beta' was observed at seven days, which diminished over time. The OVZ-E group presented the lowest mineral apposition rate at seven days. No difference was observed for the remaining periods. The SHAM, OVZ-E and OVZ-A...
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Effects of estrogenic compounds on neuronal apoptotic pathways /Linford, Nancy J., January 2001 (has links)
Thesis (Ph. D.)--University of Washington, 2001. / Vita. Includes bibliographical references (leaves 103-131).
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Mechanisms of estrogen rapid signaling /Wade, Christian Bernard, January 2002 (has links)
Thesis (Ph. D.)--University of Washington, 2002. / Vita. Includes bibliographical references (leaves 93-113).
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Estrogen in the development of esophageal and gastric adenocarclinoma /Chandanos, Evangelos, January 2007 (has links)
Diss. (sammanfattning) Stockholm : Karolinska institutet, 2007. / Härtill 4 uppsatser.
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Applied relaxation as treatment of vasomotor symptoms in postmenopausal women /Nedstrand, Elizabeth, January 2005 (has links) (PDF)
Diss. (sammanfattning) Linköping : Linköpings universitet, 2005. / Härtill 5 uppsatser.
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Hormonal treatments and the breast : effects on sex steroid receptor expression and proliferation /Isaksson Friman, Erika, January 2002 (has links)
Diss. (sammanfattning) Stockholm : Karolinska institutet, 2002. / Härtill 6 uppsatser.
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Etiology of gastroesophageal reflux /Nilsson, Magnus, January 2004 (has links)
Diss. (sammanfattning) Stockholm : Karol inst., 2004. / Härtill 4 uppsatser.
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An epidemiologic study of epithelial ovarian malignancies : with a focus on hormone-related factors /Riman, Tomas, January 2003 (has links)
Diss. (sammanfattning) Stockholm : Karol. inst., 2003. / Härtill 4 uppsatser.
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The effect of sex hormones on hemostasis and cardiovascular riskfactors in postmenopausal women /Pripp, Ulla, January 2004 (has links)
Diss. (sammanfattning) Stockholm : Karol. inst., 2004. / Härtill 5 uppsatser.
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Testosterone treatment in women : aspects on sexuality, well-being and metabolism /Flöter Rådestad, Angelique, January 2004 (has links)
Diss. (sammanfattning) Stockholm : Karol. inst., 2004. / Härtill 5 uppsatser.
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