Mice were exposed to diesel exhaust for 9 months prior to evaluation for benzo(a)pyrene disposition. On the last day of exposure the mice were instilled intratracheally with tritiated-benzo(a)pyrene ([3H]BP). The mice were sacrificed at intervals of 2, 24, and 168 hours. Disappearance of radioactivity from lungs and liver was rapid and essentially linear with time. In lungs, liver, and testes; [3H]BP metabolites were found mainly as conjugates, a form readily excretable. Clearance of the hydrocarbon from liver and testes in exposed mice was not markedly different from that in nonexposed mice. However, mice exposed to diesel exhaust had delayed [3H]BP clearance from lungs, possibly due to [3H]BP adsorption to diesel smoke particles.

Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1982. / MICROFICHE COPY AVAILABLE IN ARCHIVES AND ENGINEERING. / Includes bibliographical references. / by Seyed Hossein Mansouri. / Ph.D.

Background: Air pollution is associated with negative health effects. Exposure to combustion-derived particulate matter (PM) air pollution has been related to increased incidence of cardiovascular and respiratory morbidity and mortality, specifically in susceptible populations. Ambient particles, with a diameter of less than 2.5 mm, have been suggested to be the strongest contributor to these health effects. Diesel exhaust (DE) is a major source of small combustion-derived PM air pollution world wide.  In healthy volunteers, exposure to DE, has been associated with airway inflammation and impaired vasomotor function and endogenous fibrinolysis. The aims of this thesis were to further elucidate the underlying mechanisms to the reported cardiovascular effects following exposure to DE, with specific focus on endothelin-1 (ET-1). Additionally, the vascular effects of the major gaseous component of DE, nitrogen dioxide (NO2), were assessed together with the impact of an exhaust particle trap to reduce the observed negative vascular effects after DE exposure. Methods: In all studies healthy, non-smoking male volunteers were included and exposed for one hour during intermittent exercise in a randomised double-blind crossover fashion. In studies I-III, subjects were exposed to DE at a particulate matter concentration of approximately 300 μg/m3 and filtered air, on two different occasions. In study V an additional exposure was employed, during which DE was filtered through an exhaust particle trap. In study IV subjects were exposed to nitrogen dioxide (NO2) at 4 ppm or filtered air. In study I, thrombus formation and platelet activation were assessed using the Badimon ex vivo perfusion chamber and flow cytometry. Study II comprised the determination of arterial stiffness including pulse wave analysis and velocity. In studies III-V, vascular assessment was performed using venous occlusion plethysmography. In studies IV and V, the vascular responses to intra-arterially infused endothelial-dependent and endothelial-independent vasodilatators were registered. In study III, vascular responses to intra-arterial infusion of Endothelin-1 (ET-1) and ET-1-receptor antagonists were assessed. Venous occlusion phlethysmography was in all cases performed 4-6 hours following exposures. Blood samples for markers of inflammation, coagulation and platelet activation were collected before and throughout the study periods in studies III and V. Results: Exposure to DE increased ex vivo thrombus formation and arterial stiffness, in terms of augmentation index. DE inhalation impaired vasomotor function and endogenous fibrinolysis. The exhaust particle trap reduced the particle concentration by 98% and abolished the effects on vasomotor function, endogenous fibrinolysis and ex vivo thrombus formation. Plasma concentrations of ET-1 and its precursor big-ET-1 were unchanged following exposure. Dual endothelial receptor antagonism caused similar vasodilatation after both exposures, although vasodilatation to the endothelin-A receptor alone was blunted after DE exposure. ET-1 infusion induced vasoconstriction only following DE exposure. Exposure to nitrogen dioxide did not affect vascular function. Conclusion: Inhalation of diesel exhaust in young healthy men impaired important and complementary aspects of vascular function in humans; regulation of vascular tone and endogenous fibrinolysis as well as increased ex vivo thrombus formation. The use of an exhaust particle trap significantly reduced particle emissions and abolished the DE-induced vascular and prothrombotic effects. The adverse vascular effects following DE exposure do not appear to be directly mediated through the endothelin system. Neither is NO2 suggested to be a major arbiter of the DE-induced cardiovascular responses. Arterial stiffness is a non-invasive and easily accessible method and could thus be employed to address vascular function in larger field studies. Taken together, this thesis has given further knowledge about the mechanisms underlying the DE-induced vascular effects.

The research performed in this work investigated evaporative spray cooling systems using water near a 45 degree bends in gas turbine exhaust piping systems. Both experimental data and numerical data were generated with the goal of evaluating the ability of Fluent 6.3.26 to predict the performance of these systems for the purpose of design using only modest computational resources. Three cases were investigated in this research: single phase exhaust flow with no water injection, injecting water before the bend and injecting water after the bend. Various probes were used to measure dry bulb temperature, total pressure and water mass flux of the two phase flow at the exit of the pipe. Seven hole probes and pitot static probes were used to measure single phase flow properties. Numerical simulations were performed using mass flow boundary conditions which were generated from experimental results. A turbulence model was selected for the simulations based on comparisons of single phase simulations with experimental data and convergence ability. Using Fluent’s discrete phase model, different wall boundary conditions for the discrete phase were used in order to find the model which would best match the evaporation rates of the experimental data. Mass flux values through the exit plane of the pipe were found to be the most reliable of all the two phase data collected. Results from numerical simulations revealed the shortcomings of the available discrete phase wall boundary conditions to accurately predict the interaction of the liquid phase with the wall. Experimental results for both cases showed extensive areas of the wall which had liquid film layers running down the length of the pipe. Simulations resulted in particles either failing to impact the wall and create a liquid film, or creating a liquid film which was much smaller than the film present in experimental results. This led to 8% and 15% discrepancy in evaporation amounts between numerical and experimental results for water injection upstream and downstream of the bend respectively. Under-prediction of areas wetted with a wall film in the simulations also led to gross over predictions of wall temperature in numerical results. / Thesis (Master, Mechanical and Materials Engineering) -- Queen's University, 2014-01-02 11:02:00.955

Thesis (M.S.)--West Virginia University, 1999. / Title from document title page. Document formatted into pages; contains xii, 120 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 102-107).

Thesis (M.S.)--West Virginia University, 2000. / Title from document title page. Document formatted into pages; contains xvi, 129 p. : ill. Includes abstract. Includes bibliographical references (p. 78-82).

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The aim of this diploma thesis is the design and tuning of the exhaust manifold and muffler for the Formula Student car. The single cylinder atmospheric spark ignition engine Husaberg FE 570 is used as a powertrain unit. The exhaust system is designed according to the Formula Student rules. To design the exhaust system has been used as theoretical knowledge as well as software Lotus Engine Simulation.

The experiments detailed in this thesis give necessary preliminary information for analyzing the theoretical potential of direct exhaust pulse energy harvesting through expander devices. A detailed review of pertinent literature determined that there has been little specific focus on directly converting exhaust pulse energy into useful power. Crank position resolved exhaust pressure was measured as engine load and speed were varied to quantify their influences. Potential theoretical improvements average a 15.6% increase in overall fuel conversion efficiencies while indicated power can potentially be increased by an average of 14.3% for the operating conditions tested. A potential increase of up to 20% in indicated specific fuel consumption was shown. With increasing regulations on combustion engine efficiencies, emissions, and fuel requirements, the ability to reduce waste energy through improving existing waste energy recovery (WER) technologies and proposing novel WER strategies that maximize WER have the potential to be extremely valuable.