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Differential binding of hnRNP K, L and A2/B1 to an exonic splicing silencer element located within exon 12 of glucose-6-phosphate dehydrogenase mRNAGriffith, Brian Nelson. January 2006 (has links)
Thesis (Ph. D.)--West Virginia University, 2006. / Title from document title page. Document formatted into pages; contains xi, 183 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references.
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Evaluation of bone biochemical markers and inflammatory markers in yearlings fed varying ratios of omega-6 and omega-3 polyunsaturated fatty acidsRoss, Trinette Noel 15 May 2009 (has links)
Diets formulated to contain varying ratios of omega 6 to omega 3 fatty acids were
fed to exercising yearlings to evaluate bone activity and inflammatory response. Nine
Quarter Horse yearlings were arranged within a triplicated 3 X 3 Latin Square
experimental design and fed one of three diets. Exercise protocol was designed to
stimulate sub-clinical inflammation and normal bone response.
Body weight and physical growth measurements were not different between
groups (P > 0.05), and feed intake was similar between groups (P > 0.05).
Horses consuming soybean oil (SBO) diet had lower fatty acid profiles (% by
weight) of C16:0 and C16:1 (P < 0.05) when compared to horses consuming either corn
oil (CO) or menhaden/corn oil (MCO) diets. Though numerically different, percentage
changes in C16:0 and C16:1 were not different between diets (P < 0.05). Horses
consuming MCO had significantly higher measurements of C20:4, C20:5 and C22:6 over
the 28 day period when compared to horses consuming SBO or CO. Percent change in
mean concentrations of C20:5 were significantly different between the MCO group and the SBO group (P < 0.05) with no observed difference between MCO and CO treatment
groups.
Overall mean carboxyterminal telopeptide of type I collagen (ICTP)
concentrations did not differ between diets (P > 0.05) nor was there a significant change
from baseline values when compared to day 28 of the period.
Mean Osteocalcin (OC) concentrations did not differ between treatments (P >
0.05). Numerically, OC levels were lower after 14 days, with subsequent increases
occurring from day 14 to day 28; however, there was no significant day effect (P > 0.05).
Mean measurements of PGE2 and fibrinogen, the two inflammation markers
evaluated, did not differ among groups (P > 0.05). However, when fibrinogen data were
normalized, horses consuming SBO had a significantly lower change in baseline values
of fibrinogen compared to horses fed CO or MCO diets (P< 0.05).
In general, horses fed SBO exhibited reduced levels of the inflammatory marker
fibrinogen (P< 0.05). No other variable evaluated was influenced by the supplementation
of varying ratios of polyunsaturated fatty acids into the equine diet.
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Production of structured lipids via enzymatic interesterification of gamma-linolenic acid (GLA) and marine oils /Spurvey, Sharon A., January 2002 (has links)
Thesis (M.Sc.)--Memorial University of Newfoundland, 2002. / Bibliography: leaves 144-173.
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Synthesis and properties of tellurium-containing long chain fatty acidderivatives周晞, Chau, Hei. January 1993 (has links)
published_or_final_version / Chemistry / Doctoral / Doctor of Philosophy
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A molecular genetic approach to reducing the saturated fatty acid content of canola oilBondaruk, Mandy, University of Lethbridge. Faculty of Arts and Science January 2003 (has links)
Brassica napus is known to contain an endogenous and soluble stearoyl-acyl carrier protein (^918:0-ACP) desaturase, but does not express a palmitic (16:0)-ACP desaturase. Levels of 16:0 are low in canola oil and are associated with enhanced cholesterol biosynthesis in humans. In an attempt to further reduce the saturated fatty acid (SFA) content of canola oil, B. Napus L. cv Westar was transformed with a cDNA encoding a ^916:0-ACP desaturase from cat's claw (Doxantha unguis-cati L.). Arabidopsis thaliana was also transformed with this cDNA. Transformation of both oilseeds resulted in increased production of palmitoleic acid (^16:1) and many other effects of fatty acid composition. Overall, the SFA content did not decrease in either oilseed and investigation to why this effect occurred was examined using transgenic B. napus. Molecular genetic testing on second generation B. napus also determined the plants contained the cDNA of interest and were transcribing the cDNA. / xxi, 155 leaves : ill. ; 29 cm.
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The effect of fatty acid chain length on energy metabolism in healthy women /Papamandjaris, Andrea A. January 1999 (has links)
The effect of fatty acids on energy metabolism has been shown to be dependent on their acyl structure. In humans, following short term feeding, medium chain triglycerides (MCT) have been shown to increase the thermic effect of food and fat oxidation as compared to long chain triglycerides (LCT). Short term results in animals have been comparable. In longer term, animal studies, MCT vs. LCT have resulted in less weight gain during overfeeding or refeeding after weight loss. However, observations of the longer term effects of MCT in humans beyond 7 days are sparse and inconclusive. Hence, the objective of the thesis was to examine the effects of MCT vs. LCT on total energy expenditure, its components basal metabolic rate and thermic effect of food, and on substrate oxidation, including both exogenous and endogenous fat oxidation for a period of one week, following one week of prefeeding. Twelve healthy college aged women were fed eucaloric 14 days diets enriched with either MCT or LCT in a randomized cross over design, with a two week washout period. Doubly labelled water, respiratory gas exchange analysis, and 1-13C labelled myristic, palmitic, and stearic acids were used to measure total energy expenditure, components of energy expenditure, and endogenous long chain fatty acid oxidation, respectively. The presence of MCT in the diet significantly increased endogenous oxidation of labelled long chain fatty acids following 14 days of feeding, while the presence of LCT did not. Respiratory gas exchange analysis showed significantly increased basal metabolic rate on day 7 of MCT vs. LCT feeding, but this effect of diet was reduced to a trend by day 14. Dietary treatment did not result in significant differences in total energy expenditure during the second week of feeding. These results suggest that, after two weeks of feeding, MCT continue to affect energy metabolism through increased endogenous fat oxidation and a suggestion of heightened basal metabolic rate, but
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Antiarrhythmic mechanisms of omega-3 polyunsaturated fatty acids in rat ventricular cardiomyocytes / Wayne R. Leifert.Leifert, Wayne R. January 2001 (has links)
Includes bibliographical references (leaves 237-257). / xx, 257 leaves : ill. ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Investigates the mechanisms underlying the antiarrhythmic effects of omega-3 polyunsaturated fatty acids using adult rat ventricular cardiac myocytes. / Thesis (Ph.D.)--Adelaide University, Dept. of Physiology, 2001
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Measurement of fish consumption in population-based studies of cancer /Mina, Kym Deanne. January 2007 (has links)
Thesis (Ph.D.)--University of Western Australia, 2007.
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Regulation of glucose-6-phosphate dehydrogenase by polyunsaturated fatty acids in cultured rat hepatocytesStabile, Laura P. January 1999 (has links)
Thesis (Ph. D.)--West Virginia University, 1999. / Title from document title page. Document formatted into pages; contains x, 125 p. : ill. Vita. Includes abstract. Includes bibliographical references.
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The omega-3 fatty acid content of krill protein concentrate influences bioavailability, tissue deposition, peroxidation, and metabolism in young ratsBridges, Kayla Marie. January 2009 (has links)
Thesis (M.S.)--West Virginia University, 2009. / Title from document title page. Document formatted into pages; contains vii, 42 p. : ill. Includes abstract. Includes bibliographical references (p. 29-35).
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