In this paper we examine the possibilities to develop the population based research in Sweden by using technological advancements. The problem that exists with population based research today is that there is a contrast between conducting important research on one side and preserving the individuals’ integrity on the other. To examine this problem we are studying two projects that are active in this area. The two projects are SIMSAM (Swedish Initiative for research on Microdata in the Social and Medical Sciences) and DDB (Demografiska databasen). We have collected data from publicly available data sources as well as conducted interviews with individuals active in these projects and an individual who has been a participant in funding these projects. To analyze the gathered data we have used our analytical framework which is information infrastructure. The research question posed is discussed and finally our findings are summarized.