Thesis (doctoral)--Universität Leipzig, 1820. / Includes bibliographical references.

by Edith M.C. Lau. / Thesis (M.D.)--Chinese University of Hong Kong, 1989. / Bibliography: p. 97-109.

Thesis (Ph.D.)--Case Western Reserve University, 2009 / Abstract Department of Biomedical Engineering Title from PDF (viewed on 13 April 2009) Available online via the OhioLINK ETD Center

Thesis (M.D.)--College of Physicians and Surgeons of the University of the State of New York, 1819. / Microform version available in the Readex Early American Imprints series.

Thesis (doctoral)--University of Göteborg.

Thesis (doctoral)--University of Göteborg.

Orientador: Mario Mantovani / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas / Made available in DSpace on 2018-07-19T11:01:03Z (GMT). No. of bitstreams: 1 CaponeNeto_Antonio_M.pdf: 2280145 bytes, checksum: 74b363196683758f358977eaaafae5f8 (MD5) Previous issue date: 1992 / Resumo: Desenvolveu-se este estudo para avaliar a eficácia e segurança da cateterização da veia femoral no atendimento inicial ao politraumatizado. Estudou-se estudados prospectivamente 67 casos nos quais tentou-se este procedimento. O tempo necessário para executá-lo e as complicações imediatas eram anotadas. Em todos os casos obteve-se o "Trauma Score" e o "Injury Severity Score" para comparação com outros estudos e determinação da gravidade dos casos estudados. Houve sucesso na cateterização em S9 casos (88%) que foram seguidos, em média, por 10 dias. O tempo médio para executar o procedimento foi de 2,2 minutos e a cateterização foi mantida por 2 dias em média. Investigou-se as possíveis complicações venosas através de exames clínicos, de Doppler venoso e ultrassonográfico, realizados de modo seriado. Estudou-se a incidência de infecção através da cultura semi-quantitativa das pontas dos cateteres. Ao final, observou-se que não ocorreram complicações venosas, que houve um caso' de cateterização arterial inadvertida sem outras conseqüências e que três cateteres tiveram cultura positiva. Concluiu-se que a cateterização da veia femoral oferece uma alternativa rápida, segura e adequada de acesso venoso, no atendimento inicial de pacientes politraumatizados / Abstract: This study was undertaken to assess the efficacy and safety of femoral venous catheterization for initial management of multiple trauma patients. During a one-year period there were 67 insertion attempts of a large-bore catheter (8Fr) into the femoral veins. Fifty-nine of them were successful. Ali immediate complication was noted. In order to provide a method for comparing this study with other ones and for determining what kind of patients were studied, the Trauma Score and the Injury Severity Score were obtained in each case. The patients who underwent a femoral vein catheterization were followed up until discharged from the hospital (mean time = 10 days). The femoral cannulation was mantained for two days (mean duration). For monitoring venous complications, besides clinical-exams, Doppler venous and B-mode ultrassonography were made. Microbiological study of the catheters were done by semi-quantitative culture. No venous complications occurred. There were one inadvertent arterial catheterization without further consequences and three positive catheter tip cultures from patients without septic manifestations. It was concluded that the femoral vein catheterization offers a suitable, safe and rapid alternative of venous access In the severely injuried patient / Mestrado / Cirurgia Geral / Mestre em Medicina

No description available.

No description available.

Background: Atherosclerosis is a systemic inflammatory disease characterized by the formation of atheromatous plaques within arteries. These plaques can be classified as unstable or stable based on their morphology and cellular infiltrate. Anatomical location of plaques and age of atheroma defines the symptoms of disease. However, there is little in the literature to support this. The study aimed to compare the cellular composition, morphology, lipid biochemistry and 18F- flurodeoxyglucose (18F-FDG) positive emission tomography (PET) uptake between plaques from patients with recently symptomatic carotid disease and patients with symptomatic peripheral arterial disease undergoing intervention. Patients and Method Patients with symptomatic carotid (≥60%) or femoral stenosis undergoing intervention were recruited. All patients underwent 18F-FDG PET scanning prior to operation. The numbers of plaque macrophage and T cells were determined by immunohistochemistry (IHC). Double IHC defined the proportion of classically (M1) activated macrophages (iNOS, MHC II and SOCS-3 positive) or alternatively (M2) activated (dectin-1, CD163; SOCS-1). Plaque composition was quantified by a new morphological definition based on percentage area of fibrooconnective tissue, lipid, calcification and cellular infiltrate. The proportion of fatty acids within plaque lipids was estimated by liquid chromatography. Results 34 patients with symptomatic carotid disease and 34 with symptomatic femoral disease were recruited. 18F-FDG PET imaging was carried out successfully in 29 carotid and 29 femoral artery disease patients. 32 carotid and 25 femoral plaques were obtained. Significant differences were noted between carotid and femoral plaques with respect to the number of macrophages (p<0.001), T cells (p<0.001) and proportion of classical (p<0.001) and alternatively (p<0.001) activated macrophages and morphological analysis with evidence of more inflammation in carotid plaques. Lipid analysis revealed higher triglyceride n-6 PUFAs in carotid compared to femoral plaques (p=0.01). FDG uptake between carotid and femoral plaques was not significantly different and did not correlate with immunohistochemical, plaque morphometry or lipid analysis parameters. FDG uptake correlated with degree of symptomatic carotid stenosis (Spearman‟s coefficient=0.482;p=0.008) and symptomatic ABPI (Spearman‟s coefficient=-0.414;p=0.025). FDG uptake was higher in the symptomatic carotid compared to the contralateral asymptomatic carotid (p=0.016). Conclusion This study has shown substantial difference between morphological and cellular compositions of carotid and femoral plaques. Carotid plaques from recently symptomatic patients exhibited significantly greater percentage areas of lipid deposition, lymphocytic and monocyte/macrophage infiltrate and reduced cap thickness, in line with their more vulnerable nature. Moreover, there were a greater proportion of classically activated macrophages that are associated with plaque vulnerability. In contrast, percentage areas of fibroconnective tissue were higher in the femoral plaques. 18F-FDG PET imaging, although capable of identifying plaque inflammation, may not be adequately sensitive to differentiate between vulnerable and stable complex plaques.