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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

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Showing 1 to 2 of 2 (0.066 seconds)
1

Charakterizace myší s konstitutivně aktivní Wnt/beta-katenin signální dráhou v oční čočce / Characterization of mice with constitutively active Wnt/beta-catenin signaling pathway in lens

Antošová, Barbora January 2011 (has links)
Lens development and differentiation are strictly regulated processes. Various disturbances of these processes can lead to vision-limiting pathologies. The vertebrate lens is composed of epithelial cells and terminally differentiated fiber cells. Differentiation of fiber cells is connected with expression of fiber cell specific proteins (such as crystallins), cell cycle exit, and finally with the degradation of cell nucleus and organelles. Wnt/β-catenin signaling plays important roles during early eye development as well as later during the lens differentiation. To investigate the consequences of constitutive activation of Wnt/β-catenin signaling in lens fiber cells transgenic mouse strain, called CLEF, was created. Constitutive activation of Wnt/β-catenin signaling in fiber cells of CLEF mouse is achieved by transgenic protein CLEF that contains C-terminal activation domain of β-catenin fused to the amino terminus of full-length protein Lef1. The expression of CLEF transgene is under the control of αA-crystallin promoter. As a result of constitutive activation of Wnt/β-catenin signaling in fiber cells, adult CLEF mice develop cataracts and microphthalmia, and the morphology of adult mutant lenses is disrupted. Transgenic CLEF mRNA is expressed starting from E13.5 and by E16.5 transgenic CLEF protein is...
2

TRANSCRIPTIOME ANALYSIS AND EPIGENETIC REGULATION OF OCULAR LENS DEVELOPMENT

Hoang, Thanh V. 11 November 2016 (has links)
No description available.
Biology
Biomedical Research
Genetics
Zoology
Lens
epithelial cells
fiber cells
RNA sequencing
small RNA sequencing
differential expression
DNMT1
DNMT3A
DNMT3B
miRNA
Crispr, Cas9
miR-1
miR-184
miR-26a
miR-26b
knockout
lens development
fiber cell differentiation
cataract

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