281 |
Tertiary Lymphoid Tissues Are Microenvironments with Intensive Interactions between Immune Cells and Proinflammatory Parenchymal Cells in Aged Kidneys / 高齢個体腎における三次リンパ組織は免疫細胞と向炎症性腎実質細胞の密な相互作用が形成される微小環境であるYoshikawa, Takahisa 23 January 2024 (has links)
京都大学 / 新制・課程博士 / 博士(医学) / 甲第25004号 / 医博第5038号 / 新制||医||1070(附属図書館) / 京都大学大学院医学研究科医学専攻 / (主査)教授 長船 健二, 教授 生田 宏一, 教授 上野 英樹 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM
|
282 |
Mechanobiology Of Soft Tissue Differentiation: Effect Of Hydrostatic PressureShim, Joon Wan 05 August 2006 (has links)
This study was motivated by a theoretical formulation on mechanobiology of soft and hard skeletal tissue differentiation. To prove this formulation experimentally, I hypothesized that cartilaginous phenotype can be induced in vitro in a seemingly non-cartilaginous cell source from fibrous tissue. In testing this hypothesis, I have focused on cartilage as a target and fibrous tissue as an origin or the source of cell. Four different trials were pursued with one supposition in common, i.e. hydrostatic pressure is one of the main driving forces for chondroinduction in vitro. The first and second trials pertained to the influence of a relatively short and long duration cyclic hydrostatic compression on rat Achilles tendon fibroblasts. The third trial was to examine the effect of two different drugs on cytoskeletal elements of mesenchymal stem cells or mouse embryonic fibroblast lines in pellet cultures combined with the similar duration and/or frequency of cyclic hydrostatic pressure adopted in the aforesaid trials with no pharmacological agents added. Last, attempts were made to implement an advanced technique in molecular biology called 'PCR array' to further quantify expression levels of eighty four pathway-specific genes in mouse TGFbeta/BMP signaling traffic under the same physiological regimen of hydrostatic compression. Results demonstrated that transdifferentation in phenotype from tendon to fibrocartilage may have occurred in vitro in tendon fibroblasts in pellet cultures exposed to hydrostatic pressure. Experiments on the role of the cytoskeleton in mechanotransduction of the applied level of hydrostatic pressure demonstrated that disruption of microfilaments in the presence of cytochalasin-D did not significantly interfere with the anabolic effect of cyclic pressure. However, disruption of microtubule assembly by nocodazole abolished the pressure-induced stimulation in cartilage marker genes. These findings suggest that microtubules, but not microfilaments, are involved in mechanotransduction of hydrostatic pressure by mesenchymal stem cells.
|
283 |
The Effects of Cardiotonic Steroids on Dermal Collagen Synthesis and Wound HealingEl-Okdi, Nasser Samir 18 June 2008 (has links)
No description available.
|
284 |
Fibroblast growth factor-23 in canine chronic kidney diseaseHarjes, Laura 01 September 2017 (has links)
No description available.
|
285 |
Regulation of Eicosanoid Signaling in Airway Inflammation and Remodeling during AsthmaAl-Azzam, Nosayba Zakariya January 2017 (has links)
No description available.
|
286 |
The Role of Fibroblast Growth Factor-2 Isoforms in Ischemia-reperfusion Injury and CardioprotectionLiao, Siyun 23 April 2008 (has links)
No description available.
|
287 |
Azithromycin in periodontal therapy: pharmacokinetic and mechanistic investigationsLai, Pin-Chuang January 2015 (has links)
No description available.
|
288 |
Chemosensitization of urologic cancers by FGF inhibitorsLyness, Greg Donald 14 July 2005 (has links)
No description available.
|
289 |
Molecular pharmacodynamics of chemotherapy: fibroblast growth factor (FGF) inhibitors as chemosensitizersWalsh, Colin T. 13 September 2005 (has links)
No description available.
|
290 |
Understanding the Role of Stromal PTEN Regulated miR-101 and miR-130b in Tumor MicroenvironmentBiyik, Rumeysa 29 August 2012 (has links)
No description available.
|
Page generated in 0.0327 seconds