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Magister Scientiae Dentium - MSc(Dent) / Ossifying fibroma (OF) is the most frequent of the three fibro-osseous lesions of the jaws. It occurs mostly in patients between the age of 20 and 40 years. Females are more commonly affected than males. Clinically, OF usually presents as a painless expansive intra-bony mass. Swelling and pain may be present in some cases while some lesions are discovered incidentally. Radiographically, OF is usually well-defined and unilocular or multilocular. Early lesions present as well-defined radiolucency that are small in size. Over time, the lesions tend to enlarge in size and become mixed radiolucent-radiopaque and finally become completely radiopaque. The aim of this study was to determine the clinical and radiological features of ossifying fibroma presenting at the Departments of Maxillo-Facial and Oral Surgery and Diagnostics and Radiology, University of the Western Cape Oral Health Centre as well as to assess its management and recurrence patterns. A retrospective case series analysis was performed of all histopathologically diagnosed ossifying fibroma cases available at the Departments of Maxillo-Facial and Oral Surgery and Diagnostics and Radiology at the Faculty of Dentistry, University of the Western Cape from 1976-2014. Patient's age, gender and ethnicity were recorded. The clinical presentation of the lesion as well as the history was analyzed. Radiographic features including density, size, shape, location, locularity and its effect on adjacent structures was noted. Management of each case and follow-up was also documented. A total 61 cases were included in the study. The majority of patients were females (63.9%) and below 40 years of age (73.9%). Few cases were symptomatic (29.5%) with an average period 22 months from first symptoms to presentation. The mandibular posterior region was most affected (55.5%) while larger lesions occurred more frequently in younger patients. Majority of lesions were radiopaque (49.2%) and had well-defined margins (93.6%). Most cases were managed by surgical curettage (68.2%). Following an average follow-up period of 20 months only one case recurred (recurrence rate =6.7%). In conclusion, the majority of the clinical and radiographic findings of ossifying fibroma were similar in South African patients as those of other populations. Differences include that the lesions in this population were more radio-opaque and larger in size than in the reported literature. Surgical curettage is an acceptable management protocol with low rate of recurrence.

Thesis (Ph. D.)--University of Wisconsin--Madison, 1961. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

Thesis (M.S.)--University of Wisconsin--Madison, 1970. / eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).

This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).

Made available in DSpace on 2014-06-12T23:01:48Z (GMT). No. of bitstreams: 2 arquivo955_1.pdf: 2138051 bytes, checksum: e4518ba9524d8002437a4eceb498a326 (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2010 / Universidade Federal de Pernambuco / Objetivo: Analisar aspectos clínicos e histopatológicos dos casos de lesões fibro-ósseas benignas (LFOBs) dos maxilares. Método: Foi realizado um estudo retrospectivo dos 19 casos de LFOBs dos maxilares diagnosticadas no laboratório de Patologia Oral da Universidade Federal de Pernambuco no período compreendido entre 1998 e 2009. Foram avaliados dados clínicos referentes ao gênero e idade dos pacientes, localização anatômica e tempo de evolução das lesões, assim como as hipóteses diagnósticas aventadas pelos profissionais requisitantes dos exames histopatológicos. Para o estudo histomorfológico, as LFOBs foram avaliadas quanto à morfologia, grau de maturação e atividade osteoblástica do tecido ósseo. A sobreposição dos principais achados histológicos também foi analisada. Resultados: Dentre as lesões analisadas, 9 eram displasias fibrosas (DFs), 6 fibromas ossificantes (FOs) e 4 displasias ósseas (DOs), sendo 2 floridas, 1 periapical e 1 focal. Todas as LFOBs apresentaram forte predileção pelo gênero feminino e acometeram mais a mandíbula. Com relação às características histomorfológicas do tecido ósseo, a maior parte das DFs e DOs mostrou trabéculas curvilíneas com padrão não-lamelar e sem pavimentação osteoblástica. Os FOs apresentaram maior variabilidade de morfologia do tecido ósseo, com a presença de depósitos esféricos. O trabeculado exibiu atividade osteoblástica, e ambos os padrões de maturação óssea foram verificados. Quando comparadas entre si, as LFOBs apresentaram coincidência em metade dos aspectos histopatológicos analisados. Conclusões: Houve significativa similaridade entre os achados histomorfológicos avaliados. Os dados clínicos não se mostraram suficientes para realizar a distinção diagnóstica entre as lesões, o que indica deficiência de informações no preenchimento das fichas clínicas

Indiana University-Purdue University Indianapolis (IUPUI) / The purpose of this investigation was to study the incidence of enamel pitting and gingival fibromas in patients with tuberous sclerosis complex (TSC) and relate these findings to other physical findings of TSC, to sporadic and familial disease, and to specific TSC2 mutations. Methods: A total of 104 patients between 1 and 51 years of age were examined for enamel pits and gingival fibromas. All study subjects had a definitive diagnosis of TSC and were participants in a related study that provided results from MRI scans of the brain, echocardiography, renal ultrasound, neuropsychological assessments, and retinal examinations. Blood samples were obtained from each participant for DNA extraction and subsequent TSC mutational analysis. Results: Enamel pitting was seen in 29% of patients between 1 and 6 years of age, in 90% between 6 and 13 years of age, and in 100% of patients in the permanent 113 dentition. The majority of the pits were pinpoint sized and primarily affected the maxillary anterior arch. The maxillary central incisor was the most often affected permanent tooth and the maxillary canine was the most often affected primary tooth. Gingival fibromas were apparent in 47% of subjects in the mixed dentition and in 70% of subjects in the permanent dentition. Only one patient out of 31 in the primary dentition had a gingival fibroma. The majority of fibromas affected the interdental papilla of the maxillary anterior arch. There were few significant findings relating the degree and/or severity of enamel pitting and/or gingival fibromas to other physical findings of TSC. Enamel pitting in primary as well as permanent teeth were found to be strongly related to the presence of facial angiofibromas and a somewhat weaker association was seen with cardiac arrhythmias. Gingival fibromas were strongly related to the presence of facial angiofibromas and more weakly related to retinal lesions. There were no distinctions apparent between oral findings in sporadic and familial TSC nor were there any genotype-phenotype correlations between oral findings and TSC2 mutations. Conclusion: The combination of enamel pitting and gingival fibromas, as minor features of TSC, should raise the suspicion level regarding tuberous sclerosis as a diagnosis. Both are important minor features frequently seen which may help in establishing a definitive diagnosis. Scanning the dentition and gingiva is noninvasive, is inexpensive, and should be included in evaluating all patients suspect of a diagnosis of tuberous sclerosis.

This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).

Orientador: Pablo Agustin Vargas / Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba / Made available in DSpace on 2018-08-18T23:49:50Z (GMT). No. of bitstreams: 1 Ribeiro_AnaCarolinaPrado_D.pdf: 3258651 bytes, checksum: 970c0be7e5e81418de0473e4d576d304 (MD5) Previous issue date: 2011 / Resumo: A displasia fibrosa (DF) e o fibroma ossificante central (FOC) fazem parte de um grupo de lesões conhecido como fibro-ósseas benignas (LFOB) e afetam principalmente a maxila, a mandíbula e ossos da região craniofacial. Caracterizam-se pela substituição do tecido ósseo normal por uma matriz de tecido conjuntivo fibroso com níveis variados de material mineralizado. As DFs e os FOCs costumam apresentar características clínicas e histopatológicas similares, entretanto, possuem padrões distintos de progressão e comportamento biológico. Portanto é muito importante fazer a distinção diagnóstica entre estas lesões. Este trabalho teve como objetivos analisar e comparar as características demográficas, clínicas, imaginológicas e histopatológicas de pacientes diagnosticados com DFs e FOCs. Foi realizada uma análise retrospectiva internacional e multi-institucional que selecionou 68 casos de DF e 37 casos de FOC e permitiu o estudo de características clinicopatológicas. As DFs (n=41; 60,2%) e os FOCs (n=24; 64,9%) foram mais comuns em pacientes do gênero feminino na segunda e terceira década de vida. As DFs acometeram preferencialmente a maxila (n=38; 56%) e os FOCs a mandíbula (n=23; 62,2%). Com relação aos aspectos imaginológicos, as DFs apresentaram-se predominantemente como lesões radiopacas com limites mal definidos e os FOCs como lesões radiolúcidas bem delimitadas. Microscopicamente, foi possível evidenciar continuidade do osso lesional com a cortical óssea de revestimento nas DFs e, interessantemente, um fenômeno de separação entre as trabéculas ósseas lesionais e o estroma adjacente também foi evidente nas DFs. Nos FOCs, foi possível evidenciar a descontinuidade da lesão com a cortical óssea de revestimento externo e a presença de estruturas semelhante ao cemento. Em conclusão, o diagnóstico de DF e FOC deve ser realizado a partir da correlação das características clínicas, imaginológicas e histopatológicas. No entanto, foi possível observar algumas características peculiares em cada uma das lesões, o que poderá auxiliar o diagnóstico e consequentemente favorecer o tratamento dos pacientes acometidos por estas patologias ósseas / Abstract: Fibrous dysplasia (FD) and ossifying fibroma (OF) comprehend a group of benign fibro-osseous lesions (BFOL) which mainly affects the maxilla, mandible and craniofacial bones. They are characterized by the replacement of normal bone tissue by a matrix of fibrous connective tissue with varying degrees of mineralization. Both lesions frequently share clinical and microscopic features and the final diagnose require a combined analysis of clinical, radiologic and histological data. There might be significant cosmetic and functional impairment despite having a distinct pattern of progression and biological behavior, therefore, it is important to distinguish them from each other at the final diagnose. This research focused on the study and comparison of the demographic, clinical, imaging and microscopic aspects of patients with FD and OF, at the moment of the diagnostics. A retrospective multiinstitucional research was conducted in which there were 68 FD cases and 37 of OF. Characteristics such as gender, age and anatomic site of the tumor samples were obtained from the medical records. FDs (n=41; 60,2%) and OFs (n=24; 64,9%) were more frequently detected in female patients who were at the second or third decade of life. The maxilla was more prominently affected among the FD cases (n=38; 56%) contrasting to the prevalence of the mandible in the OF cases (n=23 62.2%). According to the radiographic aspects, FDs frequently presented as radiopaque lesions, with ill-defined limits, and OFs had well defined margins and were radiolucid. Microscopically, a continuity of the lesion with the bone cortical was evident in the FDs, as well as a separation phenomenon between the bone trabeculae and the surrounding connective tissue of the adjacent stroma. In OFs, the discontinuity of the lesion with the bone cortical was noticed, so were the presence of cement-like structures. In conclusion, the diagnose of FD and OF must be done based on the sum of the clinical, radiographic and microscopic features, although it was possible to observe a few peculiar characteristics in each one of them, which might serve as a diagnostic tool and therefore improve the treatment of the patients / Doutorado / Patologia / Doutor em Estomatopatologia