Abstract Photovoltaic (PV) solar panels are solar energy collection systems with increasing terrestrial and roof applications reported worldwide. If the terrestrial mounting does not require specific wind resistance verifications, installing them on top of flat and gable roofs implies a drastic change of the roofing systems geometry, thus a re-evaluation of the wind-induced pressure is necessary. Among the roof top applications, provisions exist for the flat roofs mounted solar panels, however, design recommendations for wind-induced loadings on PV solar panels arrays flush-mounted on gable roofs are not fully developed in current wind loading standards (SEAOC PV2-2012) and building codes (ASCE 07, NBCC 2015), in spite of the numerous applications on residential and agricultural buildings, primarily due to the limited research investigating this topic. The current dissertation employs CFD k-ɛ and LE (Large Eddy) simulations for analyzing the effects of wind acting on solar panels flush-mounted on gable roofs, considering the influence of several parameters such as: the slope of the gable roof, the wind directions, the spaces between the adjacent solar panel arrays and the clearance between the roof surface and the solar panels. A comprehensive database of solar panels with different installation parameters subjected to wind speeds were developed under the current research project. The database includes detailed distribution of wind-induced pressure coefficients for the three parallel surfaces constituting the roof-solar panels systems: the top and bottom surfaces of the panels, and the roof surface under the panels, which represents a novel approach in investigating and clarifying the wind effects on solar panels. This approach also provides in detail the variation of the pressure coefficients on the three surfaces, due to the change of installation conditions (roof slope, arrays spacing, roof clearance) and wind parameters (wind speed and wind direction). As an original contribution to the existing knowledge, this thesis found that the installation of solar arrays on gable roofs, redistributes the wind-induced pressure on both sides of the roof windward and leeward, resulting in total horizontal wind-induced pressures on the entire roof lower than that registered on the corresponding roof without solar panels. In addition, dominant resultant pressure coefficients on solar panels concluded to be lower than for the roof without panels. When the roof clearance increases, total average pressure coefficients on the roof supporting the panels decreases on both, windward and leeward sides of the roof. Moreover, when the roof clearance increases, the pressures in the cavity decrease significantly on both windward and leeward sides of the roof, which could impact the requirements for installing and fixing such panels on gable roofs. For example, for 10” clearance the flush-mounted solar panels were subject to pressure instead of suction. Similarly, when panel array spacing increases, the magnitude of the net mean pressure coefficients on the roof surface under the solar panels further decreases for all wind directions investigated.