Alzheimer's Disease (AD) is a neurodegenerative disorder that is prevalent among the elderly population. Aß protein has been heavily implicated in the pathogenesis of AD. This protein in its fibrillar form is a major component in the senile plaques that form on neuronal cellular membranes during the course of AD. Despite substantial efforts the exact mechanism of Aß toxicity towards a cell membrane is not well-understood. The determination of this mechanism, however, is of utmost importance, since the membrane presents the first site of Aß interaction with neurons, which in turn maybe the origin of Aß neurotoxicity. The purpose of this study was to find a lipid composition that can be used as a model of neuronal membrane for subsequent studies of the role of topographical heterogeneity (domain formation) on Aß-membrane interaction as related to AD. The lipids used in the study were 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC), 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol (POPG), cholesterol (Chol), sphingomyelin (SM) and ganglioside GM1 (GM1). These lipids were combined in different proportions and deposited on a mica substrate to form supported monolayers. They were then imaged with an atomic force microscope (AFM) to determine if any of them exhibited domain formation. Three of the studied samples: POPC/POPG/SM 40:40:20 +5%Chol, POPC/SM/Chol 75:20:5 and POPC/SM/GM1/Chol 74:2:1:23 were found to possess interesting topography, rich in structural features: pores and domains. The average height difference between the domain features for each sample was found to be 0.58±015 nm, 0.61±0.12 nm and 0.27±0:07 nm.

Thesis (PhDBiomedicalScience)--University of South Australia, 2001.

Thesis (PhD)--University of South Australia, 1997

Thesis (Ph. D.)--Duke University, 2007. / Includes bibliographical references.

Thesis (M.S.)--West Virginia University, 2008. / Title from document title page. Document formatted into pages; contains x, 63 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 62-63).

Thesis (M.S.)--West Virginia University, 2008. / Title from document title page. Document formatted into pages; contains x, 81, 9 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 73-75).

Thesis (Master)--İzmir Institute Of Technology, İzmir, 2006 / Keywords: Atomic force microscope, self assembled monolayer organic films, nanolithografy Includes bibliographical references (leaves. 109-112).

Thesis (Ph.D.)--University of Nebraska-Lincoln, 2007. / Title from title screen (site viewed June 17, 2008). PDF text: xiii, 146 p. : ill. (some col.) ; 4 Mb. UMI publication number: AAT 3295233. Includes bibliographical references. Also available in microfilm and microfiche formats.

Thesis (Ph. D.)--Civil and Environmental Engineering, Georgia Institute of Technology, 2005. / Dr. Rina Tannenbaum, Committee Member ; Dr. Michael Sacks, Committee Member ; Dr. Sotira Yiacoumi, Committee Chair ; Dr. Costas Tsouris, Committee Co-Chair ; Dr. Ching-Hua Huang, Committee Member. Vita. Includes bibliographical references.

Thesis (Ph. D.)--School of Chemistry and Biochemistry, Georgia Institute of Technology, 2005. Directed by Lawrence A. Bottomley. / William D. Hunt, Committee Member ; Nicholas V. Hud, Committee Member ; L. Andrew Lyon, Committee Member ; Lawrence A. Bottomley, Committee Chair ; Loren D. Williams, Committee Member. Vita. Includes bibliographical references.