Bibliography: leaves 221-237. / xi, 237 leaves : ill. ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Presents prospective data on forearm bone status in a group of Australian children. / Thesis (Ph.D.)--University of Adelaide, Dept. of Paediatrics, 1997?

Thesis (M.Sc.)--York University, 2007. Graduate Programme in Kinesiology and Health Science. / Typescript. Includes bibliographical references (leaves 76-88). Also available on the Internet. MODE OF ACCESS via web browser by entering the following URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:MR29623

Thesis (M. Sc.)--York University, 2002. Graduate Programme in Kinesiology and Health Science. / Title on certificate page: Contributions of posture and force to forearm EMG during grip tasks. Typescript. Includes bibliographical references (leaves 108-119). Also available on the Internet. MODE OF ACCESS via web browser by entering the following URL: http://wwwlib.umi.com/cr/yorku/fullcit?pMQ71610.

No description available.

O objetivo deste estudo foi de analisar a confiabilidade teste reteste do posicionamento dos eletrodos na aquisição do sinal eletromiográfico dos músculos do antebraço na tarefa de preensão palmar, por meio de dois posicionamentos. O primeiro posicionamento proposto por Cram; Durie e o segundo proposto por Mogk; Keir. Foram recrutados 30 voluntários sendo divididos em 2 grupos com 15 indivíduos cada. O primeiro grupo era formado por indivíduos saudáveis, isto é, que não apresentavam qualquer patologia, trauma ou dor no membro superior. Este grupo era composto por 13 mulheres e 2 homens com idade média de 23,4 anos, sendo 13 destros e 2 canhotos. O segundo grupo era formado por indivíduos que apresentavam algum trauma no antebraço, punho ou mão, recrutados no centro de reabilitação e no ambulatório de cirurgia do membro superior do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo. A amostra era composta por 13 homens e 2 mulheres com idade média de 34,6 anos, sendo 14 destros e 1 canhoto. Todos os participantes assinaram o Termo de Consentimento Livre e Esclarecido. O procedimento foi realizado em dois dias com diferença de 24h entre as avaliações. A avaliação consistia em realizar a tarefa de preensão palmar com o dinamômetro analógico da marca Jamar® , realizando a máxima contração voluntária pelo período de 10 segundos com repouso de 3 minutos entre cada preensão, sendo coletados o sinal eletromiográfico de sete canais dos músculos do antebraço volar e dorsal, segundo cada método. Foi analisada a confiabilidade pelo índice de ICC e o SEM (Standard Error of Measurement). Os resultados obtidos mostram excelente correlação entre os dois posicionamentos em ambos os grupos. Quando verificado o valor de ICC do grupo de saudáveis verificou valores acima de 0.75 em todos os canais, o que demonstrou uma alta correlação entre as medidas em ambos os posicionamentos, com pequeno SEM. No grupo pacientes foi observado que nos músculos FUC, FSD e ERC uma correlação moderada para o posicionamento Mogk; Keir e somente no músculo FRC apresentou correlação moderada no posicionamento Cram; Durie. Os gráficos de Bland e Altman mostraram alta concordância entre as medidas, visto que, em ambos os posicionamentos, os valores ficaram entre o intervalo de confiança de 95% e próximos da linha média. Como conclusão pode-se inferir que ambos os posicionamentos apresentaram alta confiabilidade e alta correlação quando avaliado por meio do teste e re-teste, podendo ser utilizados para medida eletromiográfica dos músculos do antebraço / The objective of this study was to analyze test retest reliability of the electrodes placement in the acquisition of electromyography forearm muscles during a isometric hand grip task, through two different methods. The first method was proposed by Cram; Durie and the second by Mogk; Keir. We recruited 30 volunteers divided into 2 groups with 15 subjects each. The first group consisted of healthy subjects, who did not show any pathology, trauma or pain in the upper extremity. This group consisted of 13 women and 2 men with a mean age of 23.4 years, and 13 right-handed and 2 left-handed. The second group consisted of individuals who had previous trauma on the forearm, wrist or hand. They were recruited from the rehabilitation center and upper limb surgery clinic of the Medical School of Ribeirão Preto Clinical Hospital. The sample consisted of 13 men and 2 women with a mean age of 34.6 years, 14 right-handed and left-handed one. All participants signed the consent form. The procedure was performed in two days with 24 hours difference between assessments. The evaluation was to carry by a isometric handgrip task with a analog dynamometer Jamar®, with maximum voluntary contraction for 10 seconds with 3 minutes of rest and analised by CCI and SEM (Standard Error of Measurement) . The results obtained have a high correlation between the two methods in both groups. Analyzing the ICC value of the healthy group value noted above 0.75 in all channels, demonstrating a excelent correlation between the measurements in both positions and low SEM. Checking in group patients realize that the FUC, FSD and ERC muscles has a moderate correlation for Mogk; Keir positioning and only on FRC showed moderate correlation in Cram; Durie electrode placement method. Analyzing Bland and Altman method a high concordance was found between the measures, since in both positions, the values were between the confidence interval of 95% and close to the midline. Through this we can infer that both positions have high reliability and high correlation when measured by the test and retest

No description available.

Thesis (doctoral)--Ludwig-Maximilians-Universität zu München, 1978.

O objetivo deste estudo foi de analisar a confiabilidade teste reteste do posicionamento dos eletrodos na aquisição do sinal eletromiográfico dos músculos do antebraço na tarefa de preensão palmar, por meio de dois posicionamentos. O primeiro posicionamento proposto por Cram; Durie e o segundo proposto por Mogk; Keir. Foram recrutados 30 voluntários sendo divididos em 2 grupos com 15 indivíduos cada. O primeiro grupo era formado por indivíduos saudáveis, isto é, que não apresentavam qualquer patologia, trauma ou dor no membro superior. Este grupo era composto por 13 mulheres e 2 homens com idade média de 23,4 anos, sendo 13 destros e 2 canhotos. O segundo grupo era formado por indivíduos que apresentavam algum trauma no antebraço, punho ou mão, recrutados no centro de reabilitação e no ambulatório de cirurgia do membro superior do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo. A amostra era composta por 13 homens e 2 mulheres com idade média de 34,6 anos, sendo 14 destros e 1 canhoto. Todos os participantes assinaram o Termo de Consentimento Livre e Esclarecido. O procedimento foi realizado em dois dias com diferença de 24h entre as avaliações. A avaliação consistia em realizar a tarefa de preensão palmar com o dinamômetro analógico da marca Jamar® , realizando a máxima contração voluntária pelo período de 10 segundos com repouso de 3 minutos entre cada preensão, sendo coletados o sinal eletromiográfico de sete canais dos músculos do antebraço volar e dorsal, segundo cada método. Foi analisada a confiabilidade pelo índice de ICC e o SEM (Standard Error of Measurement). Os resultados obtidos mostram excelente correlação entre os dois posicionamentos em ambos os grupos. Quando verificado o valor de ICC do grupo de saudáveis verificou valores acima de 0.75 em todos os canais, o que demonstrou uma alta correlação entre as medidas em ambos os posicionamentos, com pequeno SEM. No grupo pacientes foi observado que nos músculos FUC, FSD e ERC uma correlação moderada para o posicionamento Mogk; Keir e somente no músculo FRC apresentou correlação moderada no posicionamento Cram; Durie. Os gráficos de Bland e Altman mostraram alta concordância entre as medidas, visto que, em ambos os posicionamentos, os valores ficaram entre o intervalo de confiança de 95% e próximos da linha média. Como conclusão pode-se inferir que ambos os posicionamentos apresentaram alta confiabilidade e alta correlação quando avaliado por meio do teste e re-teste, podendo ser utilizados para medida eletromiográfica dos músculos do antebraço / The objective of this study was to analyze test retest reliability of the electrodes placement in the acquisition of electromyography forearm muscles during a isometric hand grip task, through two different methods. The first method was proposed by Cram; Durie and the second by Mogk; Keir. We recruited 30 volunteers divided into 2 groups with 15 subjects each. The first group consisted of healthy subjects, who did not show any pathology, trauma or pain in the upper extremity. This group consisted of 13 women and 2 men with a mean age of 23.4 years, and 13 right-handed and 2 left-handed. The second group consisted of individuals who had previous trauma on the forearm, wrist or hand. They were recruited from the rehabilitation center and upper limb surgery clinic of the Medical School of Ribeirão Preto Clinical Hospital. The sample consisted of 13 men and 2 women with a mean age of 34.6 years, 14 right-handed and left-handed one. All participants signed the consent form. The procedure was performed in two days with 24 hours difference between assessments. The evaluation was to carry by a isometric handgrip task with a analog dynamometer Jamar®, with maximum voluntary contraction for 10 seconds with 3 minutes of rest and analised by CCI and SEM (Standard Error of Measurement) . The results obtained have a high correlation between the two methods in both groups. Analyzing the ICC value of the healthy group value noted above 0.75 in all channels, demonstrating a excelent correlation between the measurements in both positions and low SEM. Checking in group patients realize that the FUC, FSD and ERC muscles has a moderate correlation for Mogk; Keir positioning and only on FRC showed moderate correlation in Cram; Durie electrode placement method. Analyzing Bland and Altman method a high concordance was found between the measures, since in both positions, the values were between the confidence interval of 95% and close to the midline. Through this we can infer that both positions have high reliability and high correlation when measured by the test and retest

One of the earliest sub-clinical stages associated with atherosclerosis is endothelial dysfunction (ED), which has been shown to predict future cardiovascular events. Chronic exercise is thought to improve endothelium-dependent vasodilation; however, few studies have evaluated the effects of acute exercise on vascular function (VF). Moreover, studies evaluating ED following an exercise training program lack a standardized time frame in which to measure VF. Although most studies require subjects to abstain from exercise for 24 hours prior to any VF measure, no study to date has assessed VF longer than 24 hours after the cessation of exercise. Additionally, no studies have compared VF responses in obese and non-obese individuals following acute exercise. Purpose: Therefore, the purpose of this study was to evaluate VF, as determined by the assessment of forearm blood flow (FBF) and vascular reactivity (VR) before and up to 48 hours after a single bout of maximal exercise in obese and non-obese males. Methods: Twelve obese (37.0 ± 1.1 kg/m2) and twelve non-obese (21.9 ± 0.3 kg/m2) males volunteered to participate. FBF was assessed before and during reactive hyperemia (RH). FBF measures were obtained prior to (PRE-E), immediately after (POST-E), and at 1 (POST-1), 2 (POST-2), 24 (POST-24), and 48 (POST-48) hours after exercise. Total excess flow, calculated as the difference between baseline FBF and FBF during RH, was used as an indicator of VR. Blood samples were also obtained at each time point to evaluate the response of interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α), which are potential modifiers of VF. Results: Baseline FBF and FBF during RH were significantly (P < 0.05) increased in both groups POST-E before returning to baseline values by POST-1. VR was enhanced in both groups POST-E, although the magnitude of change was greater in non-obese males. VR was significantly (P < 0.05) increased in non-obese males POST-E and was not significantly (P < 0.05) reduced until POST-48. Concentrations of IL-6 and TNF-α were unchanged in response to exercise in non-obese and obese males. Conclusions: An acute bout of maximal exercise significantly increased forearm endothelium-dependent vasodilation in non-obese and obese males. Additionally, an increased reactive vasodilation was observed only in non-obese males following exercise. These results also suggest that in non-obese males, measurements used to verify improvements in VF following exercise training should be employed after a minimum of 48 hours following physical activity.

Background: Cardiovascular disease continues to remain a leading cause of morbidity and mortality in both developing and developed worlds. The sirtuin and urocortin systems are novel hormone systems in humans with an emerging role in cardiovascular physiology and pathophysiology. Through a series of studies, this thesis examines the cardiovascular effects of SRT2104 (a novel small molecule SIRT1 activator) in otherwise healthy cigarette smokers and in patients with type 2 diabetes mellitus, and of urocortins 2 and 3 in healthy volunteers and in patients with heart failure. Methods: Twenty-four otherwise healthy cigarette smokers and 15 subjects with stable type 2 diabetes participated in a randomised, double blind, placebo controlled, crossover trial and received 28 days of oral SRT2104 (2.0 g/day) or matched placebo. Plasma SRT2104 concentrations, serum lipid profile, plasma fibrinolytic factors, markers of platelet and monocyte activation and pulse wave analysis and velocity were measured at baseline and the end of each treatment period together with an assessment of forearm blood flow during intra-arterial bradykinin, acetylcholine and sodium nitroprusside infusions. The pharmacodynamic profile of urocortins 2 and 3 were assessed in 18 healthy male volunteers recruited into a series of randomised, double blind, placebo controlled, crossover studies. Bilateral forearm venous occlusion plethysmography was performed during incremental intra-arterial infusions of urocortin 2 (3.6-120 pmol/min), urocortin 3 (1.2-36 nmol/min) and substance P (2-8 pmol/min) in the presence or absence of inhibitors of cyclooxygenase (aspirin), cytochrome P450 metabolites of arachidonic acid (fluconazole) and nitric oxide synthase (L-NG-monomethyl-arginine (L-NMMA)). Finally, 12 patients with stable heart failure (New York Heart Association (NYHA) II-IV) and 10 age- and sex-matched healthy volunteers were recruited to attend once each. Bilateral forearm arterial blood flow was measured using forearm venous occlusion plethysmography during incremental intra-arterial infusions of urocortin 2 (3.6-36 pmol/min), urocortin 3 (360-3600 pmol/min) and substance P (2-8 pmol/min). Results: SRT2104 was safe and well tolerated in otherwise healthy cigarette smokers and subjects with type 2 diabetes mellitus. There were no significant differences in fibrinolytic or blood flow parameters between placebo and SRT2014. Treatment with SRT2104 was associated with a significant reduction in augmentation pressure (P=0.0273) and a trend towards improvement in the augmentation index (AIx) and corrected augmentation index (0.10 > P > 0.05 for both) without significant changes in pulse wave velocity (PWV) and time to wave reflection (Tr) (P > 0.05). Administration of SRT2104 had a favourable effect on lipid profile in otherwise healthy cigarette smokers in comparison to placebo. Urocortins 2 and 3 evoked arterial vasodilatation (P < 0.0001) without tachyphylaxis but with a slow onset and offset of action. Inhibition of nitric oxide synthase with L-NMMA reduced vasodilatation to substance P and urocortin 2 (P≤0.001 for both) but had little effect on urocortin 3 (P > 0.05). Neither aspirin nor fluconazole affected vasodilatation induced by any of the infusions (P > 0.05 for all). In the presence of all three inhibitors, urocortin 2- and urocortin 3-induced vasodilatation were attenuated (P < 0.001 for all) to a greater extent than with L-NMMA alone (P≤0.005). The vasodilatory effects of urocortins 2 and 3 were preserved in patients with heart failure. Conclusion: Activation of SIRT1 through SRT2104 improved lipid profile but did not produce demonstrable differences in vascular or platelet function with some effect on measures of arterial stiffness. Urocortins 2 and 3 appear to be potent arterial vasodilators whose vasomotor responses remained preserved in patients with heart failure and were at least partly mediated via the endothelium. Both hormone systems hold potential in their role in cardiovascular disease in man but require further studies to help translate findings of this thesis to clinical practice.