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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Selección de aptámeros de RNA capaces de inhibir a la isoforma Ll2 de la esfingomielinasa D, toxina principal del veneno de la araña de rincón (Loxosceles laeta)

Salinas Luypaert, Catalina Francisca January 2013 (has links)
Tesis (bioquímica)--Universidad de Chile, 2013 Tesis (magíster en bioquímica, área de especialización en bioquímica toxicológica y diagnóstico molecular)--Universidad de Chile, 2013
2

Kinetická analýza enzymové aktivity modelových hemových senzorových proteinů / Enzyme activity analysis of function domains belonging to model heme-containing sensor proteins

Prošková, Veronika January 2018 (has links)
EN This Ph.D. thesis focuses on the heme containing gas sensor proteins. These proteins are predominantly present in bacteria, in which play an important role in processes like, sporulation, antibiotic resistance and so on. Heme containing sensor proteins composed of two domains. First one is a globin domain, which contains the heme molecule. Interaction of heme with gas molecule acts as a signal for the activation/inactivation of the second functional domain. Part of this thesis is formed by a review, which summarized the current knowledge about heme containing sensor proteins. In the next part of this thesis we focused on three representatives from the group of oxygen sensor proteins - histidine kinase AfGcHK, diguanylate cyclase YddV and phosphodiesterase EcDOS. The main aim of this thesis was to solve the mechanism of interdomain/intraprotein signal transduction in two oxygen sensor proteins with globin fold of their sensor domain (AfGcHK, YddV). For this purpose, we used the kinetic analysis of their functional domain activity and the methods of structural biology. We also studied the mechanism of interprotein signal transduction in AfGcHK and its cognate partner RR protein. It was also tested, how the presence of sodium disulfide affects the functional properties of oxygen sensor proteins...

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