京都大学 / 0048 / 新制・課程博士 / 博士(理学) / 甲第20887号 / 理博第4339号 / 新制||理||1623(附属図書館) / 京都大学大学院理学研究科数学・数理解析専攻 / (主査)准教授 福島 竜輝, 教授 中島 啓, 教授 牧野 和久 / 学位規則第4条第1項該当 / Doctor of Science / Kyoto University / DFAM

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Yes / The development of ultra-high performance cementitious composite (UHPCC) represents a significant advancement in the field of concrete science and technology, but insufficient hydration and high autogenous shrinkage relatively increase the pores inside UHPCC, in turn, affecting the macro-performance of UHPCC. This paper, initially, optimized the pore structure of UHPCC using different types and dimensions of nanofillers. Subsequently, the pore structure characteristics of nano-modified UHPCC were investigated by the mercury intrusion porosimeter method and fractal theory. Finally, the fluid permeability of nano-modified UHPCC was estimated by applying the Katz-Thompson equation. Experimental results showed that all incorporated nanofillers can refine the pore structure of UHPCC, but nanofillers with different types and dimensions have various effects on the pore structure of UHPCC. Specifically, CNTs, especially the thin-short one, can significantly reduce the porosity of UHPCC, whereas nanoparticles, especially nano-SiO2, are more conducive to refine the pore size. Among all nanofillers, nano-SiO2 has the most obvious effect on pore structure, reducing the porosity, specific pore volume and most probable pore radius of UHPCC by 31.9%, 35.1% and 40.9%, respectively. Additionally, the pore size distribution of nano-modified UHPCC ranges from 10-1nm to 105nm, and the gel pores and fine capillary pores in the range of 3-50nm account for more than 70% of the total pore content, confirming nanofillers incorporation can effectively weaken pore connectivity and induce pore distribution to concentrate at nanoscale. Fractal results indicated the provision of nanofillers reduces the structural heterogeneity of gel pores and fine capillary pores, and induces homogenization and densification of UHPCC matrix, in turn, decreasing the UHPCC fluid permeability by 15.7%-79.2%. / The authors thank the funding supported from the National Science Foundation of China (51978127, 52178188 and 51908103), the China Postdoctoral Science Foundation (2022M720648 and 2022M710973) and the Fundamental Research Funds for the Central Universities (DUT21RC(3)039). / The full-text of this article will be released for public view at the end of the publisher embargo on 11 May 2024.

京都大学 / 新制・課程博士 / 博士(情報学) / 甲第24740号 / 情博第828号 / 新制||情||139(附属図書館) / 京都大学大学院情報学研究科数理工学専攻 / (主査)教授 梅野 健, 教授 山下 信雄, 准教授 加嶋 健司 / 学位規則第4条第1項該当 / Doctor of Informatics / Kyoto University / DFAM

Drug delivery systems (DDS) are essentially pharmaceutical products for human therapy, typically involving a mixture of active ingredients and excipients. Based upon quantitative characterization of structure, the thesis introduces the concept of classifying the architecture of DDS into four levels by their spatial scale and the life time period. The primary level is recognised as the static structure of the whole dosage form with a size from μm to cm with the final structure generated by formulation design. The secondary level categorises the structures of particles or sub-units to form a DDS with sizes from nm to mm as key units in processing such as mixing, grinding, granulation and packing; The tertiary level represents the dynamic structures of DDS during the drug release phase in vitro or in vivo incorporating the structure size range from nm to mm, which undergo changes during dissolution, swelling, erosion or diffusion. The spatial scale for the quaternary level is defined as the meso or micro scale architecture of active and non-active molecules within a DDS with sizes from Å to μm for the molecular structure of drug and excipients. Methods combining X-ray tomography, image processing, and 3D reconstructions have been devised and evaluated to study systematically pharmaceutical structures and correlate them with drug release kinetics of DDS. Based on the quantitative structural information of pharmaceutical intermediates and dosage forms, it is possible now to correlate structures with production processing, behaviour and function, and the static and dynamic structures of DDS with the release kinetics. Thus, a structure-guided methodology has been established for the research of DDS. / Chinese Academy of Sciences

SEM and CT X-ray imaging were used to quantify the surface geometries of sandstone pore and throat networks of the oil-bearing Stanley Sandstone of the Eutaw Formation of Jasper County, Mississippi, both in dry samples and in samples that had undergone laboratory simulations of Microbial Permeability Profile Modification (MPPM) oil-recovery technology. The goal of the study was to acquire some quantified understanding of the way induced bacterial activity affected the surface geometries and impacted the porosity and permeability of the oil-bearing Stanley Sandstone. Visible porosity remained high, but significant permeability modification occurred ubiquitously with pore and throat spaces of 10 ìm – 20 μm diameter. Based upon quantitative analysis of photomicrographs, biofilm did not completely fill porosity but did clog pore throats, thus significantly impacting permeability.

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