Thesis (M.H.A.)--University of Michigan, 1972.

Thesis (M. Phil.)--University of Hong Kong, 1997. / Includes bibliographical references (leaf 172-178).

Optical interferometric techniques are being increasingly used in industry. These non contact techniques, using laser methods based on speckle interferometry, assure a greater accuracy in measuring displacements caused by deformations. One such technique, Electronic Speckle Pattern Interferometry (ESPI), has been used successfully, by analysis of the reaction of mechanical components to induced mechanical or thermal stress, for the measurements of in-situ, real time, full-field, in-plane and out-of-plane displacements and the detection of detachments, micro-cracks occurring as internal and external defects.

The intention of this study was to measure the work engagement and EVP of employees and further to investigate the relationship between work engagement and EVP. A secondary objective was to determine to determine to what extend intrinsic rewards of EVP affects work engagement more than extrinsic rewards. The study was quantitative in nature and data was obtained by means of an electronic survey. The EVP questionnaire and UWES were used to measure EVP and work engagement respectively. Results showed that there is no practical relationship between work engagement and EVP; however, evidence suggested a statistically significant relationship between work engagement and EVP. There was no evidence to suggest that in the relationship between work engagement and EVP, intrinsic components of EVP affect work engagement more than extrinsic rewards. It was however suggested that although the extrinsic rewards component of EVP are important in attracting and retaining employees, rewards had no correlation with work engagement. Implications of the findings suggest that rewards might be important when attracting and retaining employees to a company. However, in order to develop levels of work engagement rewards play no significant role. Companies should invest in enhancing the intrinsic components of their EVP to such an extent that it contributes to levels of work engagement.

No description available.

No description available.

Na primeira parte desta tese, estudamos os princípios operacionais das decisões celulares mediadas pelo sistema de sinalização Notch. Este sistema tem papel importante nas decisões celulares que ocorrem durante o desenvolvimento embrionário, cicatrização de feridas e na formação de tumores. O circuito de sinalização é ativado quando o receptor Notch de uma célula interage com um dos ligantes - Delta ou Jagged - de uma célula vizinha. O circuito Notch-Delta forma um comutador intercelular, e duas células vizinhas tendem a adotar estados diferentes - Emissor (muito ligante e pouco receptor) e Recebedor (pouco ligante e muito receptor). Neste manuscrito, apresentamos uma nova abordagem teórica que integra ambos Delta e Jagged no circuito Notch. Mostramos que o circuito Notch-Delta-Jagged permite um novo estado - um híbrido Emissor/Recebedor (E/R) com concentrações intermediárias de receptores e ligantes, e portanto o circuito é age como uma chave de três vias. Em seguida, observamos que a taxa de produção de ambos os ligantes, assim como a modulação assimétrica da afinidade de ligação do Notch com seus ligantes mediada pela glicosiltransferase Fringe, afeta severamente o intervalo de existência dos estados e sua relativa estabilidade - altos níveis de Jagged, mas não de Fringe ou Delta, promovem o estado híbrido E/R e o processo de indução lateral. Nós elucidamos o papel de Jagged na determinação dos estados celulares e discutimos sua possível implicação no entendimento da comunicação entre tumor e estroma, que frequentemente envolve comunicação via interações Notch-Jagged. Posteriormente, avaliamos a interação entre Notch, inflamação e a população de Células Cancerígenas Estaminais (CCE). Mostramos que inflamação pode expandir a população de CCE por meio do aumento dos níveis de produção de Jagged que posteriormente ativa o sistema de sinalização Notch em células vizinhas não-CCE. Nossos resultados sugerem que a inibição da produção de Jagged atenua o efeito da expansão de CCE devido a inflamação, indicando que inflamação cresce a população de CCE via interações Notch-Jagged. Nossos resultados são consistentes com observações em câncer de mama do subtipo basal (triplo negativo), onde a perda de Fringe e a ativação constitutiva do eixo NF-kB - Jag1 promove a expansão da população de CCE. Nossa abordagem computacional pode ser adaptada para incluir circuitos adicionais tais como p53 e hipóxia, que afetam a plasticidade celular, proporcionando assim uma plataforma útil para a projeção de novas terapias. Na segunda parte desta tese, introduzimos um novo método para seleção de características: Suvrel. Este é um método variacional, inspirado em aprendizado de relevância, para determinar tensores métricos para definição de distâncias baseadas em similaridades, para utilização em métodos de classificação. Nós introduzimos uma nova metodologia na qual o tensor métrico pode ser calculado analiticamente. O preprocessamento das características por uma transformação linear utilizando o tensor métrico calculado via Suvrel melhora a eficiência dos classificadores. Testamos nosso método para conjuntos de dados públicos, utilizando os classificadores mais comumente utilizados. Nós também aplicamos esta metodologia no estudo da relação entre parâmetros estruturais globais e o sistema de classificação de função enzimática. Por último, introduzimos uma nova metodologia para a identificação de genes diferencialmente expressos utilizando a tecnologia de microarranjos de DNA. Diferentemente das abordagens tradicionais, nossa metodologia evita passos intermediários de preprocessamento que são desnecessários e devido a isto não acumula erros destas análises, o que resulta em um método mais sensível e robusto. / In the first part of this thesis, we studied the operating principles of cell fate decisions mediated by Notch signaling pathway. This pathway have important role in cell fate determination during embryonic development, wound healing and tumorigenesis. Notch signaling is activated by binding of Notch receptor of one cell to either of its ligand- Delta or Jagged- of another cell. Notch-Delta circuit forms an intercellular toggle switch, and two neighboring cells tend to adopt different fates - Sender (high ligand, low receptor) and Receiver (low ligand, high receptor). Here, we present a new tractable theoretical framework that incorporates both Delta and Jagged in Notch signaling, and show that Notch-Delta-Jagged circuit enables an additional fate - hybrid Sender/Receiver (S/R) (medium ligand, medium receptor) and behaves as a three-way switch. Further, we found that production rates of both the ligands and the asymmetric modulation of binding affinity of Notch to its ligands by glycosyltransferase Fringe severely affects the parameter range of the existence of these states and their relative stability - high levels of Jagged, but not that of Fringe or Delta, promote hybrid S/R state and lateral induction. We elucidate the role of Jagged in cell fate determination and discuss its possible implications in understanding tumor-stroma crosstalk, which frequently entails Notch-Jagged communication. We further evaluate the interplay among Notch signaling, inflamation and Cancer Stem Cell population. We show that inflammation can expand the population of Cancer Stem Cells (CSCs) by increasing the levels of Jagged in cells that can further activate Notch signaling pathway in neighboring non-CSCs. Our results suggest that, inhibiting the production of Jagged dampens the effect of inflammation in expanding the CSC population, indicating that inflammatory signal function through Notch-Jagged signaling to increase CSCs. Our results are consistent with observations in basal-like breast cancer, where loss of Fringe and constitutive activation of NF-kB-Jag1 axis promotes CSC population. Our computational framework can be tailored to include additional signals such as p53 and hypoxia that affect this plasticity to gain stemness, thus providing a platform that can be useful in designing novel therapies. In the second part of the thesis, we introduce a new method for feature selection: Supervised Variational Relevance Learning (Suvrel). This is a variational method to determine metric tensors to define distance based similarity in pattern classification, inspired in relevance learning. We propose a new methodology where the metric tensor can be calculated analytically. Preprocessing the patterns by doing linear transformations using the metric tensor yields a dataset which can be more efficiently classified. We test our methods using publicly available datasets, for some standard classifiers. We also applied this methodology to study the relationship between global structural parameters and the Enzyme Commission hierarchy. Lastly, we propose a new methodology for identifying the differentially expressed genes using DNA microarray technology. Unlike traditional approaches, our methodology skips intermediate unnecessary preprocessing steps and therefore does not accumulate errors due to these analysis, resulting in a more sensitive and robust method.

張家偉. / 論文(哲學碩士) -- 香港中文大學硏究院政治與行政學部, 1997. / 參考文獻: leaves 107-116. / Zhang Jiawei. / Chapter 1. --- 緖論 --- p.1-15 / Chapter 2. --- 中國國有企業的福利制度 --- p.16-32 / Chapter 3. --- 國有企業的福利擴張趨勢 --- p.33-60 / Chapter 4. --- 中國政府對福利擴張的控制 --- p.61-74 / Chapter 5. --- 福利擴張揭示的現象-- 工人與企業經營者的關係 --- p.75-90 / Chapter 6. --- 總結 --- p.91-97 / Chapter 7. --- 附錄一：山東省某國有企業的個案硏究 --- p.98-106 / 附錄二：中國國有企業職工福利發展相關大事記 / Chapter 8. --- 參考文獻 --- p.107-116

A projected fringe profilometry (PFP) is a wide optical measurement technology to gauge the three dimensional appearance of object.Because of non-contact type , the short retrieve time and low environmental effect,PFP was usually used in many fields.PFP has become rather efficient and precise on gauging the three dimensional appearance of the static obiect because of its persistent development in recent years.However,it is still not mature yet to gauge the dynamic object. If we could develop a gauging way in the dynamic object , the application would be more widespread. First of all,using PFP as the gauging principle and utilzing the math algorithm for analyzing the changes between the dynamic measured object and the blurred fringes.Secondly,reconstructed the inspected object's three dimensional appearance and the velocity. Finally,found out the deformation of the measured object. The technology of this thesis broke through the typical measurement of velocity.We could analyze the velocities of three dimentional dirtions by only single optic imformation.

Thesis (M.H.A.)--University of Michigan, 1969.