Converging cognitive and neuroimaging evidence reveals that episodic memory and episodic future thinking (EFT) share component processes. Much less is known about the relationship between EFT and working memory (WM) processes. We hypothesized that WM capacity might provide a crucial componential cognitive role during EFT by supporting the translation of information from discrete episodic memories into a novel future event. We tested this hypothesis in two studies. In Study 1, we collected functional magnetic resonance imaging data during a dual-task interference paradigm that varied WM load and processing demands during EFT. Events imagined while actively maintaining bound item-location representations were less vivid than those imagined during low WM load control trials. Measures of functional and effective connectivity indicated that this behavioral effect corresponded with reduced coupling between the dorsomedial prefrontal cortex and right temporoparietal junction. Events imagined while simultaneously manipulating items in WM took longer to construct than events imagined during control trials and were associated with less functional coupling between the right hippocampus and posterior visuospatial regions. In Study 2, participants completed a similar WM dual-task while simultaneously recalling past events or imagining future events during scalp-recorded encephalography (EEG). As in Study 1, future events imagined while maintaining item-location representations were less vivid than control trials. This effect was specific to future events and corresponded to reduced theta reactivity over bilateral temporoparietal sites. Relative to episodic memory, EFT was associated with alpha synchronization over frontal and parietal sites as well as greater theta-gamma phase amplitude coupling in the right dorsolateral prefrontal cortex. In contrast, episodic memory was associated with greater cross-frequency coupling between frontal theta and occipital gamma oscillations. These results provide novel empirical support for previous theoretical accounts suggesting that WM capacity provides the cognitive workspace necessary to temporarily store and recombine details from discrete episodes into a future event representation. / PHD / This study used neuroimaging and behavioral techniques to identify how long-term and short-term memory processes interact to support the ability to imagine future events. The results suggest that short-term memory serves as a mental stage on which memories of the past are held and transformed into imagined scenes.

Positive, but distal consequences of reducing alcohol use among at-risk users may have little impact on behavior due to temporal discounting (Mazur, 1987), in which delayed rewards are devalued relative to more proximal rewards, even if such distal rewards actually provide considerably more value. Delay discounting may be manipulated using a variety of means, one of which involves utilizing prospective thinking about future autobiographical events and is termed Episodic Future Thinking (Atance and ONeill, 2001). Episodic future thinking (EFT) has been demonstrated in previous studies to be effective in reducing delay discounting relative to a variety of control conditions (Benoit, Gilbert, and Burgess, 2011; Daniel, Stanton, and Epstein, 2013a, 2013b; Lin and Epstein, 2014; Peters and Büchel, 2010) and recently among substance-abusing populations (Snider, LaConte, and Bickel, 2016; Stein et al., 2016). The present study examined EFT in a novel sample of at-risk alcohol users. Participants were randomized to EFT, episodic past thinking (EPT), or a control condition in which non-autobiographical events were recalled (CET). Immediately following intervention, results demonstrated significantly less discounting in EFT and EPT, relative to CET. At follow-up, EFT demonstrated significantly less temporal discounting and alcohol use, when compared to both EPT and CET. No differences among conditions in alcohol demand or alcohol use intentions were observed. The present study contributes a number of novel findings to the literature, most notably that engaging in EFT predicts reductions in alcohol use prospectively and that reductions in delay discounting associated with EFT persist at least a week later, without any additional intervention. Such findings suggest that EFT manipulations influence the valuation of future rewards. Additionally, findings support EFT as a useful supplement to existing empirically-supported treatments or a component of novel substance use disorder treatments. / Ph. D. / Drug and alcohol addiction is characterized by seemingly illogical decisions to forgo important benefits associated with abstinence or moderated use (e.g., maintaining employment) in favor of the immediate gratification of intoxication. The tendency to favor instant gratification and devalue delayed rewards explains impulsive decision making typical of substance use disorders and other impulse control problems. The present study evaluated whether vividly imagining positive future events reduced this tendency toward instant gratification. College students at high risk for an alcohol use disorder participated in the study. Participants were randomly assigned to one of three groups: one in which they were asked to imagine positive events they anticipated in the future, one in which they were asked to imagine positive events from their past, and one in which they were asked to recall events described in a provided travel blog. Immediately after imagining the events, participants in both the past and future conditions were less oriented towards instant gratification than participants who were asked to recall events from a travel blog. When measured a week later, participants in the future condition reported less devaluation of future rewards, as well as less alcohol use, than participants in the other two groups. Overall, the results of the study provide evidence that vividly imagining positive future events reduces impulsivity among at-risk college student drinkers. As such, imagining future events may be an effective component of future treatment efforts for substance use disorders and other impulse control problems.

目的　本研究嚐試探討無望感與未來思考及情緒困擾間的關係，旨在驗證MacLeod的未來思考研究，以及區分病例組與對照組的敏感性。 研究對象　非病人樣本，主要為大學生以及部分社會人士，共123名；病人樣本則為台北巿立萬芳醫院的門診病患，共49名。 研究方法　非病人樣本採用隨機取樣，病人樣本採用隨機立意取樣之病例對照研究設計。 研究材料　包括「貝克無望感量表」、「貝克焦慮量表」、「貝克憂鬱量表第二版」、「語意歷程作業」、「語文流暢作業」、與「未來思考作業」共六項。 研究結果　本研究結果符合MacLeod先前的研究結果為，即(1)無望感與正向未來思考的減少有關；與(2)憂鬱與正向未來思考的減少，及負向未來思考的增加有關。不符合MacLeod的研究果為：焦慮與未來思考的關係不顯著。另外，以「正向未來思考」及「負向未來思考」來區分病人與非病人就目前的樣本而言，是不具有敏感性的。 結論　對於臨床工作而言，須注意正向未來思考減少對個案的影響，並進一步的給予適宜的處置，以預防疾病的再發。 關鍵字　無望感、正向未來思考、負向未來思考、情緒困擾

Psychosis encompasses a constellation of symptoms that have far-reaching social, physical and functional consequences for sufferers. One of the key clinical concerns in the management of psychotic illnesses is the risk of suicide, which is greatest in the early stages of psychosis. Hopelessness is consistently associated with risk for suicide but as a concept it is not well defined and is not specific enough to be of use in prediction of suicide. Future-directed thinking, particularly regarding positive future events, constitutes an aspect of hopelessness that is closely associated with risk for suicide. This study employed the Future Thinking Task to investigate whether future-directed thinking in first episode psychosis is significantly different from that of matched controls in performance or content, and to clarify the nature of its association with suicide risk in this patient group. In addition, the association of future-directed thinking with the negative symptoms of psychosis was investigated. The results showed that individuals with psychosis were impaired in future-directed thinking globally, particularly with respect to the coming year. Specific deficits were shown in the domains of relations with other people and personal development and understanding. Associations were shown between future-directed thinking and suicide, and reduced positive future-directed thinking was shown to be strongly associated with increased severity of negative symptoms. The results suggest avenues for novel interventions to improve hopelessness, suicide risk and the severity of negative symptoms in psychotic illness, and thereby improve functional outcomes.

Episodic future thinking is defined as the ability to mentally project oneself into the future into a specific time and place. Episodic future thinking has been explored extensively in neuroscience. However, it has not been determined whether the measurement of episodic future thinking might be valuable in a clinical neuropsychological setting. The current study examined the relationship between episodic future thinking and instrumental activities of daily living (IADLs), which is a domain of adaptive functioning frequently assessed by neuropsychologists to examine independent living potential including the ability to handle finances, prepare food, complete household duties, and manage medications. A secondary aim was to examine whether episodic future thinking is related to IADLs over and above standard measures of cognition. 61 older adults with heterogeneous neurological conditions and 41 healthy older adults completed a future thinking task (the adapted Autobiographical Interview), two measures of IADLs (an informant report measure called the Everyday Cognition Scale and a performance-based measure called the Independent Living Scales), and standard measures of memory and executive functioning. Episodic future thinking was significantly associated with performance-based IADLs when accounting for age, education, gender, and depression (r=.26, p=.010). Episodic future thinking significantly predicted performance-based IADLs over and above executive functioning (R2=.025, p=.030). Episodic future thinking was not predictive of performance-based IADLs over and above memory (p=.157). Episodic future thinking was not significantly associated with informant reported IADLs when accounting for age, education, gender, and depression (p=.284). This study suggests that episodic future thinking is significantly associated with IADLs, beyond what can be accounted for by executive functioning. Episodic future thinking may provide information about IADLs to clinical neuropsychologists so they can improve their recommendations for independent living.

Impulsivity takes many forms, one of which is termed impulsive choice. Impulsive choice entails preference for an outcome due to its immediacy relative to more optimal outcomes that take longer to come to fruition. For example, one may wish to have another serving of a decadent dessert after dinner—but doing so may undermine a longer-term goal of improved health and nutrition. If having the extra serving becomes a habit, the consequences of that choice compound and may lead to, for example, obesity. A high degree of impulsive choice such as this is indeed related to issues such as obesity, drug addictions (e.g., alcohol, opiates), and more; it may also cause these conditions. Because impulsive choice may lead to the development of poor health conditions, being able to reduce impulsive choice may reduce the occurrence of these conditions and/or help treat them. To date, a variety of studies have been conducted to examine ways to reduce impulsive choice, but it was unclear what methods may be most useful for clinical use in humans. Thus, the first portion of the enclosed research was a literature review in which successful methods for reducing impulsive choice were identified. A particular intervention called Episodic Future Thinking (EFT), which entails vivid imagination of one’s future, was one of the most promising found. However, it was unclear if its positive effects on impulsive choice were due to EFT itself or a placebo-like effect, which can arise from being able to guess the purpose of the intervention. The remaining portions of this dissertation focused on determining whether people are able to identify the purpose of EFT, and subsequently, if this awareness accounts for the positive effects of EFT on impulsive choice. Across three experiments, we demonstrated that naïve individuals are able to figure out the purpose of EFT (Experiments 1a and 1b), but that being aware of its purpose is unrelated to its positive effects (Experiment 3). These findings give hope that this intervention could be clinically useful, but it did appear that its benefits did not generalize well to novel settings (Experiment 2). Overall, the results of the research showed that EFT produces genuine changes in impulsive choice, but that further research will need to be conducted to understand why it works, and ultimately, how its generalizability can be increased.

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This dissertation investigates self-projection (i.e., future and past preferences reasoning) and possible underlying mechanisms [Theory of Mind (ToM), executive function (EF)] in early development. All children were tested in person prior to the COVID-19 pandemic. Our first objective was to explore preschoolers' understanding that the preferences they may hold in the future (Future Preferences task, adapted from Bélanger, Atance, Varghese, Nguyen, & Vendetti, 2014; Experiment 1), and likely held in the past (Past Preferences task; Experiment 2), differ from their current preferences. To do so, we implemented a novel continuous measure of children's preferences (faces rating scale; Kopp et al., 2017; adapted from; Wong & Baker, 1988) in addition to the more standard categorical response measure (item selection) used in children's future preferences reasoning research (Bélanger et al.). In addressing our second objective to investigate children's past preferences reasoning, we designed a new task (Past Preferences task) to complement our Future Preferences task. In Chapter 2 (Experiments 1 & 2), we found 3-, 4-, and 5-year-olds' success in reasoning about their future and past preferences generally improved with age. Results from our continuous preferences measure further revealed subtle developments in preschoolers' preferences reasoning not gleaned from our categorical data alone. We found that, around age 4, children demonstrate some understanding that they will prefer child items less and adult items more in the future (as an adult) than they do now and, around age 3, children similarly demonstrate some understanding that they preferred child items less in the past (as a baby) than they do now. While cross-experiment comparison in Chapter 2 revealed asymmetry in preschoolers' preferences reasoning (future, relative to past, preferences reasoning was more challenging), this asymmetry was not replicated in Chapter 3 using a more rigorous within-subjects design. Besides clarification of asymmetry in preferences reasoning, our final objectives were to confirm the relation between preschoolers' reasoning about changes in their future and past preferences and explore possible mechanisms underlying children’s self-projective abilities. In Chapter 3, children's ability to reason about their future and past preferences were significantly correlated - but not after controlling for their receptive language ability. Unexpectedly, we did not find support for asymmetry in children's self-projection abilities; that is, children did not find it more difficult to reason about their future as compared to their past preferences. Finally, children's future and past preferences reasoning were not related to or predicted by their performance on the ToM and EF tasks after controlling for age, language ability, and sex. Taken together, this dissertation provides unique and timely contributions to the literature on self-projection and, specifically, how this capacity develops, as well as children’s reasoning about how preferences change over time.

Yes / Objectives To examine the impact of memory accessibility on episodic future thinking. Design Single-case study of neurological patient HCM and an age-matched comparison group of neurologically Healthy Controls. Methods We administered a full battery of tests assessing general intelligence, memory, and executive functioning. To assess autobiographical memory, the Autobiographical Memory Interview (Kopelman, Wilson, & Baddeley, 1990. The Autobiographical Memory Interview. Bury St. Edmunds, UK: Thames Valley Test Company) was administered. The Past Episodic and Future Episodic sections of Dalla Barba's Confabulation Battery (Dalla Barba, 1993, Cogn. Neuropsychol., 1, 1) and a specifically tailored Mental Time Travel Questionnaire were administered to assess future thinking in HCM and age-matched controls. Results HCM presented with a deficit in forming new memories (anterograde amnesia) and recalling events from before the onset of neurological impairment (retrograde amnesia). HCM's autobiographical memory impairments are characterized by a paucity of memories from Recent Life. In comparison with controls, two features of his future thoughts are apparent: Reduced episodic future thinking and outdated content of his episodic future thoughts. Conclusions This article suggests neuropsychologists should look beyond popular conceptualizations of the past–future relation in amnesia via focussing on reduced future thinking. Investigating both the quantity and quality of future thoughts produced by amnesic patients may lead to developments in understanding the complex nature of future thinking disorders resulting from memory impairments. / Institute of Psychological Sciences, University of Leeds

Despite decades of effort in developing evidence-based treatments, drug addiction remains one of the most problematic and enduring public health crises. Developing a new generation of theoretically-derived interventions constitutes an important clinical and scientific gap that, if addressed, may open innovative treatment opportunities. Based on the Reinforcer Pathology theory, altering the temporal window over which reinforcers are integrated (i.e., measured by delay discounting) would alter drug valuation and consumption. The first investigation—in 2 separate studies— test the Reinforcer Pathology theory by examining the effect of expanding and constricting the temporal window of integration using two mating narratives (long-term and short-term relationships, respectively) on cigarette valuation among cigarette smokers. The second investigation, test the Reinforcer Pathology theory by assessing the effect of remotely delivered Episodic Future Thinking (EFT) narratives (expands the temporal window) on real-world alcohol consumption among individuals with alcohol use disorder (AUD). Together, these investigations supported the Reinforcer Pathology theory and demonstrated its relevance for understanding and intervening in addiction. The current findings provide scientific justification to further investigate Reinforcer Pathology based interventions that expand the temporal window to change drug valuation and consumption. The construction of multi-component treatments that incorporate Reinforcer Pathology based interventions to systematically alter the temporal window may provide a novel intervention to reduce alcohol consumption. / Doctor of Philosophy / The following studies provide evidence that altering the temporal widow (how far in the future one can imagine and integrate into the present) would alter drug valuation. In the following studies, we used narratives describing long-term or short-term mating relationships (Study 1) and Episodic Future Thinking (EFT; represents one's capability to pre-experience the future; Study 2) to alter the valuation of cigarettes and alcohol, respectively. In the first study, cigarette smokers who read and vividly imagined long-term romance relationship narrative (expands the temporal window) valued cigarettes less than control (imagined looking for a lost key). In contrast, those who read and vividly imagined a short-term sexual encounter (shortens the temporal window) valued cigarettes more than controls. The second study employed EFT (expands the temporal window) as a strategy to reduce alcohol consumption, in real-world settings, over two weeks in individuals with alcohol use disorder. The study found that expanding the temporal window using EFT reduced alcohol consumption. Together, these two studies provide support to employing interventions that extend the temporal window to change drug valuation and consumption. The construction of multi-component treatments that incorporate interventions expanding the temporal window may reduce drug consumption.