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Gaba neurobiology and C1sup(-) conductance on insect muscleScott, R. H. January 1984 (has links)
No description available.
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Gaba and human spermatozoa : characterization and regulation of gaba transport proteins /Aanesen, Arthur, January 1900 (has links)
Diss. (sammanfattning) Stockholm : Karol. inst. / Härtill 5 uppsatser.
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Examining Hippocampal Reelin Expression and Neural Plasticity in an Animal Model of Depression2013 November 1900 (has links)
Stress is an important risk factor for the development of clinical depression, yet little is known about the neurobiological mechanisms by which stress might promote depressive symptomatology. The brain is particularly susceptible to the negative effects of stress, as high levels of stress hormones result in decreased hippocampal neurogenesis, slowed cell maturation, and decreased cell complexity. Although we already know that these neurobiological changes are associated with significant impairments in important psychological functions such as learning, memory and motivation, we know little about the molecular details of this stress-induced remodeling and how it contributes to the development of depression. Currently, one candidate molecule of particular interest is reelin, an extracellular matrix protein responsible for regulating neuronal maturation and synaptic plasticity in the adult brain. Interestingly, recent post- mortem analyses indicate that reelin expression is decreased in depressed patients. Similarly, preclinical research has shown that repeated glucocorticoid administration significantly reduces reelin expression in the adult hippocampus. Combined, these results suggest that reelin may be an important protein to examine in regards to the pathogenesis of depression as well as a potential therapeutic target for the treatment of this disorder.
The goal of this dissertation is to provide a comprehensive examination of the influence repeated glucocorticoid administration has on reelin expression in the rat hippocampus, and how this relates to the pathogenesis of depression. In chapter 2 we examined how co-treatment with the stress hormone corticosterone (CORT), and the antidepressant imipramine, influence reelin expression in the proliferative region of the hippocampus. In addition we determined whether changes in reelin expression are associated with alterations in neurogenesis and behavioral measures of depression. Results revealed that imipramine prevents CORT-induced downregulation of reelin in the hippocampus, and that these changes parallel improvements in FST behavior, increased neurogenesis and enhanced maturation of immature granule cells. Importantly, these data provide further evidence of reelin’s role in depression and establish this protein as a target of antidepressant treatment. In chapter 3 we examined the effect of CORT on a number of interneuron markers that co-localize with reelin throughout the hippocampus to determine whether the populations of neurons that express reelin are lost or are no longer expressing this protein. Results of this study indicate that CORT influences a number of interneuron markers in a region-specific manner in the hippocampus, but does not cause these cell populations to die, suggesting that CORT exploits an intracellular mechanism to regulate reelin expression in the hippocampus. Finally, in chapter 4, the influence of CORT on MeCP2 and DNMT1, two markers associated with DNA methylation, was examined in the hippocampus to elucidate a potential intracellular mechanism for CORT-induced reelin deficits. Results of this study indicate that CORT has no influence on global protein levels of these markers, but significantly increases the number of MeCP2-expressing cells in the proliferative subgranular zone of the hippocampus, suggesting that there is an increase in the number of methylated cells in this region. While it cannot be conclude from this study that increased methylation causes reelin deficits, the fact that an increase in MeCP2 is seen in the exact region where reelin deficits are most pronounced suggest it is possible. Moreover, these findings are novel, and suggest a role for MeCP2, and more generally, DNA methylation, in the neurobiology of depression. Collectively, the results of this dissertation enhance our understanding of the functional consequences of altered hippocampal neuroplasticity on the development of depressive symptomatology, and the role that reelin may play in this process. They also provide further support for reelin as a novel therapeutic target for the treatment of major depression.
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Development and dysfunction of GABAergic synaptic function in a seizure-prone animal model of cortical malformation /Trotter, Stacey Ann. January 2006 (has links)
Thesis (Ph. D.)--University of Virginia, 2006. / Includes bibliographical references. Also available online through Digital Dissertations.
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Epileptiform bursting in the disinhibited neonatal cerebral cortexWells, Jason Eric. January 2003 (has links)
Thesis (Ph. D.)--West Virginia University, 2003. / Title from document title page. Document formatted into pages; contains xii, 231 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references.
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The role of Hox cofactors in vertebrate spinal coed developmentRottkamp, Catherine Anne-Marie. January 2007 (has links)
Thesis (Ph. D.)--Case Western Reserve University, 2007. / [School of Medicine] Department of Neurosciences. Includes bibliographical references.
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Effects of neuroactive steroids on the recombinant GABAA receptor in Xenopus oocyte /Rahman, Mozibur, January 2007 (has links)
Diss. (sammanfattning) Umeå : Univ., 2007. / Härtill 4 uppsatser.
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Mechanisms of inhibition in the avian cochlear nucleus /Howard, MacKenzie A. January 2008 (has links)
Thesis (Ph. D.)--University of Washington, 2008. / Vita. Includes bibliographical references (leaves 105-114).
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Dendritic development of GABAergic cortical interneurons revealed by biolistic transfection with GFPJin, Xiaoming, January 2002 (has links)
Thesis (Ph. D.)--West Virginia University, 2002. / Title from document title page. Document formatted into pages; contains vii, 218 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references.
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Software development for the detection of GABAA mediated synaptic currents and its application in rat substantia nigra neurons.January 1998 (has links)
by Wu Cheok Wai. / Thesis (M.Phil.)--Chinese University of Hong Kong, 1998. / Includes bibliographical references (leaves 35-39 (2nd gp.)). / Abstract also in Chinese. / Abstract in English --- p.i / Abstract in Chinese --- p.iii / Acknowledgment --- p.v / Chapter Chapter 1: --- Introduction --- p.1 / Chapter 1.1 --- GABAa Mediated Neurotransmission --- p.1 / Chapter 1.2 --- Determinants of GABAa IPSC Kinetics --- p.3 / Chapter 1.3 --- Detection of the Spontaneous IPSCs --- p.5 / Chapter 1.4 --- The C++ Programming Language --- p.7 / Chapter Chapter 2: --- The Detection Algorithm --- p.11 / Chapter 2.1 --- Overview of the Algorithm --- p.11 / Chapter 2.2 --- Detection of Events --- p.12 / Chapter 2.3 --- Measurement of Parameters --- p.20 / Chapter Chapter 3: --- Performance Evaluation --- p.22 / Chapter 3.1 --- The Automatic Detection Software --- p.22 / Chapter 3.2 --- Performance of the Software --- p.23 / Chapter 3.3 --- Discussion --- p.25 / Chapter Chapter 4: --- Application --- p.28 / Chapter 4.1 --- Introduction --- p.28 / Chapter 4.2 --- Materials and Methods --- p.29 / Chapter 4.3 --- Results --- p.32 / Chapter 4.4 --- Discussion --- p.33 / Reference --- p.35 / Appendix --- p.40
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